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Article
Open AccessDetection for gene-gene co-association via kernel canonical correlation analysis
Currently, most methods for detecting gene-gene interaction (GGI) in genomewide association studies (GWASs) are limited in their use of single nucleotide polymorphism (SNP) as the unit of association. One way ...
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Article
Open AccessA powerful latent variable method for detecting and characterizing gene-based gene-gene interaction on multiple quantitative traits
On thinking quantitatively of complex diseases, there are at least three statistical strategies for analyzing the gene-gene interaction: SNP by SNP interaction on single trait, gene-gene (each can involve mult...
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Article
Open AccessLocal well-posedness and persistence properties for a model containing both Camassa-Holm and Novikov equation
This paper deals with the Cauchy problem for a generalized Camassa-Holm equation with high-order nonlinearities,
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Article
Open AccessIntegrative Bayesian variable selection with gene-based informative priors for genome-wide association studies
Genome-wide Association Studies (GWAS) are typically designed to identify phenotype-associated single nucleotide polymorphisms (SNPs) individually using univariate analysis methods. Though providing valuable insi...
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Article
Open AccessA powerful score-based test statistic for detecting gene-gene co-association
The genetic variants identified by Genome-wide association study (GWAS) can only account for a small proportion of the total heritability for complex disease. The existence of gene-gene joint effects which con...
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Article
Open AccessA powerful score-based statistical test for group difference in weighted biological networks
Complex disease is largely determined by a number of biomolecules interwoven into networks, rather than a single biomolecule. A key but inadequately addressed issue is how to test possible differences of the n...
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Article
Open AccessA novel Markov Blanket-based repeated-fishing strategy for capturing phenotype-related biomarkers in big omics data
We propose a novel Markov Blanket-based repeated-fishing strategy (MBRFS) in attempt to increase the power of existing Markov Blanket method (DASSO-MB) and maintain its advantages in omic data analysis.
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Article
Open AccessNetwork or regression-based methods for disease discrimination: a comparison study
In stark contrast to network-centric view for complex disease, regression-based methods are preferred in disease prediction, especially for epidemiologists and clinical professionals. It remains a controversy ...
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Article
Open AccessA powerful weighted statistic for detecting group differences of directed biological networks
Complex disease is largely determined by a number of biomolecules interwoven into networks, rather than a single biomolecule. Different physiological conditions such as cases and controls may manifest as diffe...
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Article
A new generalised two-component Camassa–Holm type system with waltzing peakons and wave breaking
This paper mainly investigate the Cauchy problem for the generalised two-component Camassa–Holm type system, which includes the celebrated Camassa–Holm equation, Degasperis equation, Novikov equation, and the ...
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Article
Open AccessPeer-to-peer electricity trading system: smart contracts based proof-of-benefit consensus protocol
Nowadays, people trade electricity through centralized companies or organizations which is vulnerable to cyber attacks and incapable of co** with increasing demands from stakeholders. In this paper, we propo...
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Article
Open AccessFyn kinase regulates dopaminergic neuronal apoptosis in animal and cell models of high glucose (HG) treatment
High glucose (HG) is linked to dopaminergic neuron loss and related Parkinson’s disease (PD), but the mechanism is unclear.
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Article
Open AccessGenome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a m...
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Article
Open AccessPhysiological and molecular mechanisms of insect appendage regeneration
Regeneration, as a fascinating scientific field, refers to the ability of animals replacing lost tissue or body parts. Many metazoan organisms have been reported with the regeneration phenomena, but showing ev...
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Article
Open AccessIsotopic and proteomic evidence for communal stability at Pre-Pottery Neolithic Jericho in the Southern Levant
As one of the key, long-term occupied sites in the Southern Levant, Jericho was one of the most important early Neolithic centres to witness social and economic changes associated with the domestication of pla...
