131 Result(s)
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Biomedicine
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Article
Open AccessKK-LC-1, a biomarker for prognosis of immunotherapy for primary liver cancer
There is mounting evidence that patients with liver cancer can benefit from Immune checkpoint inhibitors. However, due to the high cost and low efficacy, we aimed to explore new biomarkers for predicting the e...
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Open AccessEfficacy of MAGE-A4 long peptide as a universal immunoprevention cancer vaccine
The clinical application of peptide vaccines in tumor immunotherapy holds significant promise. Peptide-based tumor vaccines are currently subject to certain limitations in clinical trials, including the challe...
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Autophagy Regulation Attenuates Neuroinflammation and Cognitive Decline in an Alzheimer's Disease Mouse Model with Chronic Cerebral Hypoperfusion
This study investigates the role of autophagy regulation in modulating neuroinflammation and cognitive function in an Alzheimer's disease (AD) mouse model with chronic cerebral hypoperfusion (CCH). Using the A...
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Open AccessThe deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic mimicry and malignant progression of RMS by balancing SNAI2 homeostasis
Rhabdomyosarcoma (RMS) is a rare malignancy and the most common soft tissue sarcoma in children. Vasculogenic mimicry (VM) is a novel tumor microcirculation model different from traditional tumor angiogenesis,...
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The Synergistic Mechanisms of AIE, ESIPT and ICT in the α-cyanostilbene-based Derivative: A Red-fluorescence Probe With a Large Stokes’ Shift for Copper (II) Ion Determination and Reversible Response to Amine/acid Vapor
Herein, α-cyanostilbene-based luminogen with an electron donor-π-electron acceptor (D-π-A) architecture was formylated into the salicylaldehyde-analogue luminogen, followed by the Schiff base reaction with phe...
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Open AccessSubstantial viral diversity in bats and rodents from East Africa: insights into evolution, recombination, and cocirculation
Zoonotic viruses cause substantial public health and socioeconomic problems worldwide. Understanding how viruses evolve and spread within and among wildlife species is a critical step when aiming for proactive...
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Open AccessTargeting PCSK9 to upregulate MHC-II on the surface of tumor cells in tumor immunotherapy
Proprotein convertase subtilisin/kexin type 9 (PCSK9), the last member of the proprotein convertase family, functions as a classic regulator of low-density lipoprotein (LDL) by interacting with low-density lip...
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Open AccessIn situ chemoimmunotherapy hydrogel elicits immunogenic cell death and evokes efficient antitumor immune response
Chemoimmunotherapy has shown promising advantages of eliciting immunogenic cell death and activating anti-tumor immune responses. However, the systemic toxicity of chemotherapy and tumor immunosuppressive micr...
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Open AccessRetraction Note: TMED3 promotes cell proliferation and motility in breast cancer and is negatively modulated by miR-188-3p
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Article
An Advanced Intrahepatic Cholangiocarcinoma Patient Benefits from Personalized Immunotherapy
Advanced intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignancy characterized by limited response to standard therapeutic modalities, such as radiotherapy, chemotherapy, and targeted therapy. ...
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Meta-analysis of the Selected Genetic Variants in Immune-Related Genes and Multiple Sclerosis Risk
Previous studies have suggested that certain variants in immune-related genes may participate in the pathogenesis of multiple sclerosis (MS), including rs17824933 in the CD6 gene, rs1883832 in the CD40 gene, rs23...
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Open AccessProspective cohort study evaluating the association between influenza vaccination and neurodegenerative diseases
The effect of influenza vaccination (FluVac) on the risk of neurodegenerative diseases has not been well evaluated in prospective populations. We aimed to assess the association between FluVac and the risk of ...
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Open AccessSeveral implications for the pathogenesis and treatment of thrombosis in PNH patients according to multiomics analysis
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Increased Expression of KNa1.2 Channel by MAPK Pathway Regulates Neuronal Activity Following Traumatic Brain Injury
Recent studies have indicated that functional abnormalities in the KNa1.2 channel are linked to epileptic encephalopathies. However, the role of KNa1.2 channel in traumatic brain injury (TBI) remains limited. We ...
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Open AccessDevelopment of a machine learning-based radiomics signature for estimating breast cancer TME phenotypes and predicting anti-PD-1/PD-L1 immunotherapy response
Since breast cancer patients respond diversely to immunotherapy, there is an urgent need to explore novel biomarkers to precisely predict clinical responses and enhance therapeutic efficacy. The purpose of our...
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Real-time non-uniform surface refinement model for lung adenocarcinoma surgery
Soft tissue models play a crucial role in virtual surgery. However, most existing methods use uniform meshes and overall refinement to construct inhomogeneous soft tissues for virtual lungs. This leads to a co...
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A Novel TGF-β-Related Signature for Predicting Prognosis, Tumor Microenvironment, and Therapeutic Response in Colorectal Cancer
The transforming growth factor beta (TGF-β) signaling plays a critical role in immune evasion and tumor progression. However, its modulatory influences on prognosis, tumor microenvironment (TME), and therapeut...
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Open AccessPrenatal diagnosis and genetic etiology analysis of talipes equinovarus by chromosomal microarray analysis
With the advancement of molecular technology, fetal talipes equinovarus (TE) is believed to be not only associated with chromosome aneuploidy, but also related to chromosomal microdeletion and microduplication...
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Open AccessCorrection: Comprehensive analysis of peroxiredoxins expression profiles and prognostic values in breast cancer
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Open AccessAssociation of diabetes risk reduction diet with renal cancer risk in 101,755 participants: a prospective study
There is little prospective evidence exists about whether adherence to a diabetes risk reduction diet (DRRD) is related to a significant reduction in renal cancer risk. We sought to clarify whether adherence t...
