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Article
Associations between contrast-enhanced ultrasound features and WHO/ISUP grade of clear cell renal cell carcinoma: a retrospective study
Clear cell renal cell carcinoma (CCRCC) comprises 70%–80% of RCCs. The World Health Organization/International Society of Urology Pathology (WHO/ISUP) classification is the most important prognostic factor for...
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Chapter and Conference Paper
Research on Electric Field Safety Distance of High-Voltage Equipment in Substations Inspected by UAV
UAVs have the advantages of close observation, eliminating visual dead space, improving inspection speed and carrying a variety of inspection equipment in substation equipment inspection, which meet the needs ...
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Article
Copper Homeostasis Based on Cuproptosis-Related Signature Optimizes Molecular Subty** and Treatment of Glioma
Copper is essential in living organisms and crucial to various physiological processes. Normal physiological conditions are in a state of copper homeostasis to ensure normal biochemical and metabolic processes...
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Article
Effects of consumers’ uncertain valuation-for-quality in a distribution channel
Consumer uncertainty about product valuation is a significant economic issue in online retailing. In many markets, even though the product quality information is completely disclosed, consumers may still remai...
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Article
Single-cell Sequence Analysis Combined with Multiple Machine Learning to Identify Markers in Sepsis Patients: LILRA5
Sepsis is a disease with a very high mortality rate, mainly involving an immune-dysregulated response due to bacterial infection. Most studies are currently limited to the whole blood transcriptome level; howe...
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Article
Open AccessAuthor Correction: Phase III study of HR-positive/HER2-negative/lymph node-positive breast cancer non-responsive to primary chemotherapy: a randomized trial
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Article
Open AccessPhase III study of HR-positive/HER2-negative/lymph node-positive breast cancer non-responsive to primary chemotherapy: a randomized trial
There are few studies focus on post-neoadjuvant treatment in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-)/lymph node-positive (LN+) breast cancer, a multi-center, o...
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Article
Loss of p53 Concurrent with RAS and TERT Activation Induces Glioma Formation
There is an ongoing debate regarding whether gliomas originate due to functional or genetic changes in neural stem cells (NSCs). Genetic engineering has made it possible to use NSCs to establish glioma models ...
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Article
Nicotinamide adenine dinucleotide (NAD+) reduction enabled by an atomically precise Au-Ag alloy nanocluster
The redox property of the ultrasmall coinage nanoclusters (with several to tens of Au/Ag atoms) has elucidated the electron-transfer capacity of nanoclusters, and has been successfully utilized in a variety of...
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Article
Clearance as an Early Indicator of Efficacy for Therapeutic Monoclonal Antibodies: Circumventing Dose Selection Challenges in Oncology
The designs of first-in-human (FIH) studies in oncology (e.g., 3 + 3 dose escalation design) usually do not provide a sufficient sample size to determine the dose-response relationship for efficacy. This study...
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Article
Open AccessUse of machine learning-based integration to develop an immune-related signature for improving prognosis in patients with gastric cancer
Gastric cancer is one of the most common malignancies. Although some patients benefit from immunotherapy, the majority of patients have unsatisfactory immunotherapy outcomes, and the clinical significance of i...
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Article
Open AccessUse of machine learning-based integration to develop a monocyte differentiation-related signature for improving prognosis in patients with sepsis
Although significant advances have been made in intensive care medicine and antibacterial treatment, sepsis is still a common disease with high mortality. The condition of sepsis patients changes rapidly, and ...
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Article
Neoadjuvant endocrine therapy for strongly hormone receptor-positive and HER2-negative early breast cancer: results of a prospective multi-center study
For estrogen receptor (ER)-positive breast cancer, neoadjuvant endocrine therapy (NET) has been shown to be as effective as neoadjuvant chemotherapy (NACT). We evaluated the prognostic significance of Preopera...
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Article
Open AccessPropofol enhances stem-like properties of glioma via GABAAR‐dependent Src modulation of ZDHHC5-EZH2 palmitoylation mechanism
Propofol is a commonly used anesthetic. However, its effects on glioma growth and recurrence remain largely unknown.
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Article
Open AccessGSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis
Glioblastoma stem cells (GSCs) are a highly tumorigenic cell subgroup of glioblastoma (GBM). Glycogen synthase kinase 3β (GSK3β) is considered a key hub for promoting malignant phenotypes in GBM. However, the ...
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Article
Engineering DNA logic systems with non-canonical DNA-nanostructures: basic principles, recent developments and bio-applications
Engineering DNA logic systems is considered as one of the most promising strategies for next-generation molecular computers. Owing to the inherent features of DNA, such as low cost, easy synthesis, and control...
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Article
Open AccessCorrection: Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation
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Article
Open AccessHeterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation
Glioblastoma (GBM) is the most common and deadly of the primary intracranial tumors and is comprised of subsets that show plasticity and marked heterogeneity, contributing to the lack of success in genomic pro...
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Article
Open AccessImpact of dose-dense neoadjuvant chemotherapy on pathologic response and survival for HER2-positive breast cancer patients who receive trastuzumab
To compare outcomes in patients with human epidermal growth factor receptor-2 (HER2)-positive breast cancer who received either dose-dense neoadjuvant chemotherapy (NAC) with trastuzumab or standard-interval c...
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Article
Clinical phenotypes combined with saturation genome editing identifying the pathogenicity of BRCA1 variants of uncertain significance in breast cancer
Characterizing the pathogenicity of BRCA1 variants of uncertain significance (VUSs) is a major bottleneck in clinical management of BRCA1-associated breast cancer. Saturation genome editing (SGE) was recently rep...
