113 Result(s)
-
Article
Open AccessRapid detection of lung cancer based on serum Raman spectroscopy and a support vector machine: a case-control study
Early screening and detection of lung cancer is essential for the diagnosis and prognosis of the disease. In this paper, we investigated the feasibility of serum Raman spectroscopy for rapid lung cancer screen...
-
Article
Built-in electric field induced S-scheme g-C3N4 homojunction for efficient photocatalytic hydrogen evolution: Interfacial engineering and morphology control
S-scheme possesses superior redox capabilities compared with the II-scheme, providing an effective method to solve the innate defects of g-C3N4 (CN). In this study, S-doped g-C3N4/g-C3N4 (SCN-tm/CN) S-scheme homo...
-
Article
Open AccessTargeting NG2 relieves the resistance of BRAF-mutant thyroid cancer cells to BRAF inhibitors
BRAFV600E represents a constitutively active onco-kinase and stands as the most prevalent genetic alteration in thyroid cancer. However, the clinical efficacy of small-molecule inhibitors targeting BRAFV600E is o...
-
Article
A novel approach to characterize the correction path features for the tibia deformity correction
Preoperative correction path planning is an important preparation for obtaining the desired correction. However, a convenient and effective model has not been proposed to characterize the correction path featu...
-
Article
Open AccessSafety and efficacy of intravenous thrombolysis before mechanical thrombectomy in patients with atrial fibrillation
Intravenous thrombolysis (IVT) before endovascular thrombectomy (EVT) is the standard treatment for patients with acute ischemic stroke caused by large vessel occlusion (AIS-LVO). However, the efficacy and saf...
-
Article
Open AccessCharacterization of gene regulatory networks underlying key properties in human hematopoietic stem cell ontogeny
Human hematopoiesis starts at early yolk sac and undergoes site- and stage-specific changes over development. The intrinsic mechanism underlying property changes in hematopoiesis ontogeny remains poorly unders...
-
Article
Regulation of aqueous electrolyte interface via electrolyte strategies for uniform zinc deposition
Aqueous zinc ion batteries (AZIBs), renowned for their high theoretical energy density, safety, cost-effectiveness and eco-friendliness, offer immense potential in the realm of energy storage and conversion, f...
-
Article
Open AccessEfficacy of salvage surgery versus re-irradiation for isolated regional lymph node recurrence in patients with nasopharyngeal carcinoma
To compare the clinical characteristics and prognoses of patients with isolated regional lymph node recurrent nasopharyngeal carcinoma (irrNPC) who underwent surgery or re-irradiation treatment.
-
Article
Bronchoalveolar Lavage Fluid Microbiota is Associated with the Diagnosis and Prognosis Evaluation of Lung Cancer
The gut microbiota and cancer have been demonstrated to be closely related. However, few studies have explored the bronchoalveolar lavage fluid (BALF) microbiota in patients with lung cancer (LC), specifically...
-
Article
Open AccessA small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at the clinical level. ...
-
Article
Kinetically and thermodynamically expediting elementary steps via high-valence Cr-incorporated of nickel selenide for water electrolysis
Designing high-performance electrocatalysts toward hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) is essential to reduce the activation barrier and optimize free adsorption energy of rea...
-
Article
PPARγ Agonist Rosiglitazone and Antagonist GW9662: Antihypertensive Effects on Chronic Intermittent Hypoxia-Induced Hypertension in Rats
The increased incidence of hypertension associated with obstructive sleep apnea (OSA) presents significant physical, psychological, and economic challenges. Peroxisome proliferator-activated receptor gamma (PP...
-
Article
Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial
The combination of immune-checkpoint blockade with chemotherapy for the first-line treatment of advanced triple-negative breast cancer (TNBC) has generated mixed results. TORCHLIGHT is a randomized, double-bli...
-
Article
Open AccessMYO5A overexpression promotes invasion and correlates with low lymphocyte infiltration in head and neck squamous carcinoma
Head and neck squamous carcinoma (HNSC) poses a significant public health challenge due to its substantial morbidity. Nevertheless, despite advances in current treatments, the prognosis for HNSC remains unsati...
-
Article
Open AccessPangenome analysis reveals genomic variations associated with domestication traits in broomcorn millet
Broomcorn millet (Panicum miliaceum L.) is an orphan crop with the potential to improve cereal production and quality, and ensure food security. Here we present the genetic variations, population structure and di...
-
Article
Open AccessExperience with 2 years’ intervention to progressively reduce salt supply to kitchens in elderly care facilities—challenges and further research: post hoc analysis of the DECIDE-Salt randomized clinical trial
Progressive reduction of sodium intake is an attractive approach for addressing excessive salt intake, but evidence for this strategy in real practice is limited. We aimed to determine the feasibility, effecti...
-
Article
Open AccessVisualization of breast cancer-related protein synthesis from the perspective of bibliometric analysis
Breast cancer, as a daunting global health threat, has driven an exponential growth in related research activity in recent decades. An area of research of paramount importance is protein synthesis, and the ana...
-
Article
Open AccessDissecting transcription of the 8q24-MYC locus in prostate cancer recognizes the equilibration between androgen receptor direct and indirect dual-functions
Androgen receptor (AR) activation and repression dual-functionality only became known recently and still remains intriguing in prostate cancer (PCa). MYC is a prominent oncogene that functionally entangles wit...
-
Article
Open AccessExogenous hormone therapy and non-melanoma skin cancer (keratinocyte carcinoma) risk in women: a systematic review and meta-analysis
Previous studies reported inconsistent results regarding the association between keratinocyte carcinoma (KC) and exogenous hormone therapy. This study aimed to investigate the association between the use of ex...
-
Article
Anatomic characteristics of shoulder based on MRI accurately predict incomplete rotator cuff injuries in patients: relevance for predictive, preventive, and personalized healthcare strategies
In the diagnosis of incomplete rotator cuff injuries (IRCI), magnetic resonance imaging (MRI) and ultrasound examination often have false-positive and false-negative results, while arthroscopy is expensive, in...
