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Article
Open AccessOsteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23
Osteocytes act within a hypoxic environment to control key steps in bone formation. FGF23, a critical phosphate-regulating hormone, is stimulated by low oxygen/iron in acute and chronic diseases, however the m...
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Article
Nonlinear relationship between chromatin accessibility and estradiol-regulated gene expression
Chromatin accessibility is central to basal and inducible gene expression. Through ATAC-seq experiments in estrogen receptor-positive (ER+) breast cancer cell line MCF-7 and integration with multi-omics data, ...
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Article
Open AccessSTAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
T helper cell differentiation requires lineage-defining transcription factors and factors that have shared expression among multiple subsets. BATF is required for development of multiple Th subsets but functio...
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Article
Open AccessGenome-wide studies reveal the essential and opposite roles of ARID1A in controlling human cardiogenesis and neurogenesis from pluripotent stem cells
Early human heart and brain development simultaneously occur during embryogenesis. Notably, in human newborns, congenital heart defects strongly associate with neurodevelopmental abnormalities, suggesting a co...
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Article
Erratum to: Different site, different clinical outcomes in perforated colorectal cancer?
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Article
Different site, different clinical outcomes in perforated colorectal cancer?
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Article
Different site, different clinical outcomes in perforated colorectal cancer?
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Article
Application of proteomics in environmental science
Proteomics involves the separation of proteins, identification of the amino acid sequence of the interested or target proteins, study of the function of the proteins, modification, structure and ultimate assig...