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Open AccessHow would you describe a mentally healthy college student based on Chinese culture? A qualitative research from the perspective of college students
Promoting college students’ mental health remains a significant concern, necessitating a clear understanding of what constitutes good mental health. Variations in the conceptualizations of mental health across...
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Article
Open AccessGenome-wide study of longitudinal brain imaging measures of multiple sclerosis progression across six clinical trials
While the genetics of MS risk susceptibility are well-described, and recent progress has been made on the genetics of disease severity, the genetics of disease progression remain elusive. We therefore investig...
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Open AccessMulti-arm U-Net with dense input and skip connectivity for T2 lesion segmentation in clinical trials of multiple sclerosis
T2 lesion quantification plays a crucial role in monitoring disease progression and evaluating treatment response in multiple sclerosis (MS). We developed a 3D, multi-arm U-Net for T2 lesion segmentation, whic...
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Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia
We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We find an excess of ultra-rare pro...
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Facility-Level Variation in Reported Statin-Associated Side Effects Among Patients with Atherosclerotic Cardiovascular Disease—Perspective from the Veterans Affair Healthcare System
Statin-associated side effects (SASEs) can limit statin adherence and present a potential barrier to optimal statin utilization. How standardized reporting of SASEs varies across medical facilities has not bee...
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Lipid-Lowering Biotechnological Drugs: from Monoclonal Antibodies to Antisense Therapies—a Clinical Perspective
While low density lipoprotein cholesterol (LDL-C) remains a key contributor of atherosclerotic cardiovascular disease (ASCVD), additional risk factors identified through epidemiological and genetic studies hav...
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Practices and Outcomes of Promoting the Competencies of Psychological Assistance Professionals in Defeating the COVID-19 Pandemic
The competencies of clinical or counseling psychologists influenced the effectiveness and qualities of the psychological assistance provided after the outbreak of the COVID-19 pandemic. The following practices...
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Correction: Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder
A Correction to this paper has been published: https://doi.org/10.1038/s41380-021-01063-8
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Lens on International Clinical Supervision: Lessons Learned from a Cross-National Comparison of Supervision
Clinical supervision is an essential mechanism for training psychologists internationally. But although it is performed globally, scholarship has primarily addressed it through the lens of Western supervision ...
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Open AccessInvestigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder
Bipolar disorder (BD) is a serious mental illness with substantial common variant heritability. However, the role of rare coding variation in BD is not well established. We examined the protein-coding (exonic)...
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Association Between Omega-3 Fatty Acid Treatment and Atrial Fibrillation in Cardiovascular Outcome Trials: A Systematic Review and Meta-Analysis
Data on the relationship between omega-3 fatty acid (n-3 FA) therapy with atrial fibrillation (AF) have been inconsistent. We investigate the association between n-3 FA and risk for AF by pooling data from ava...
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Open AccessAccurate imputation of human leukocyte antigens with CookHLA
The recent development of imputation methods enabled the prediction of human leukocyte antigen (HLA) alleles from intergenic SNP data, allowing studies to fine-map HLA for immune phenotypes. Here we report an ...
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Highlights from Studies in Cardiovascular Disease Prevention Presented at the Digital 2020 European Society of Cardiology Congress: Prevention Is Alive and Well
The review highlights selected studies related to cardiovascular disease (CVD) prevention that were presented at the 2020 European Society of Cardiology (ESC) Congress—The Digital Experience.
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Letter to the Editor: Increased Circulating Angiopoietin-like Protein 8 Levels Are Associated with Thoracic Aortic Dissection and Higher Inflammatory Conditions
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Highlights of Studies in Cardiovascular Disease Prevention Presented at the 2020 American College of Cardiology Annual Scientific Session
The review highlights selected studies related to cardiovascular disease (CVD) prevention that were presented at the American College of Cardiology 2020 Virtual Scientific Session (ACC.20)/World Cardiology Con...
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Highlights from Selected Cardiovascular Disease Prevention Studies Presented at the 2019 European Society of Cardiology Congress
This review intends to highlight selected cardiovascular disease (CVD) prevention studies presented at the 2019 European Society of Cardiology (ESC) Congress.
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Major Randomized Clinical Trials in Cardiovascular Disease Prevention Presented at the 2019 American College of Cardiology Annual Scientific Session
At the 2019 American College of Cardiology annual scientific sessions, major randomized clinical trials in cardiovascular disease (CVD) prevention were presented.
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The 2018 Cholesterol Management Guidelines: Topics in Secondary ASCVD Prevention Clinicians Need to Know
The 2018 ACC/AHA Multisociety blood cholesterol guidelines provide updated recommendations based on contemporary evidence on the management of serum cholesterol for the prevention of atherosclerotic cardiovasc...
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Risk Assessment of Stroke in Patients with Atrial Fibrillation: Current Shortcomings and Future Directions
Atrial fibrillation is a well-known risk factor for cardioembolic stroke; a number of risk stratification scoring systems have been developed to help differentiate which patients would stand to benefit from an...
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Omega-3 Fatty Acid and Cardiovascular Outcomes: Insights From Recent Clinical Trials
Omega-3 fatty acids (ω-3 FA) are among the most well-recognized health supplements but their cardiovascular benefits have long been controversial owing to inconsistent results from previous cardiovascular outc...