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Article
Open AccessRecent progress of non-linear topological structure polymers: synthesis, and gene delivery
Currently, many types of non-linear topological structure polymers, such as brush-shaped, star, branched and dendritic structures, have captured much attention in the field of gene delivery and nanomedicine. C...
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Article
Experimental and Numerical Study of Joint Persistence Effect on the Non-persistent Jointed Rock Mass’ Tension Failure Behavior
Tension failure is a common failure mode for jointed rock mass, with the rock bridge as the main body subjected to the tensile load. To reveal the jointed rock mass stability, the influence of joint persistenc...
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Article
Open AccessSuperior TRAIL gene expression and cancer cell apoptosis mediated by highly branched-linear poly(β-amino ester)s
Extensive efforts have been dedicated to enhancing the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in cancer cells for the development of effective cancer treatments. However,...
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Article
Open AccessEmerging non-viral vectors for gene delivery
Gene therapy holds great promise for treating a multitude of inherited and acquired diseases by delivering functional genes, comprising DNA or RNA, into targeted cells or tissues to elicit manipulation of gene...
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Article
Open AccessThe association of serum IL-33/ST2 expression with hepatocellular carcinoma
IL-33 is a multifunctional cytokine with dual functions. However, the clinicopathological and prognostic significance of IL-33 in cancer patients, especially in patients with hepatocellular carcinoma (HCC), re...
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Article
The role of Smad6 in immunity of the pearl oyster Pinctada fucata martensii
Inhibitory Smads (I-Smads), which belong to the Smad family and inhibit bone morphogenic protein 2 (BMP2) signaling by a variety of mechanisms, can suppress innate immunity responses in vertebrates. However, t...
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Article
Deep-intronic and frameshift DSG1 variants associated with atypical severe dermatitis, multiple allergies and metabolic wasting (SAM) syndrome in a Chinese family
Severe dermatitis, multiple allergies and metabolic wasting (SAM) syndrome comprise a rare genodermatosis associated with biallelic (homozygous or compound heterozygous) mutations in the DSG1 (desmoglein-1) gene,...
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Article
Open AccessPacBio single molecule long-read sequencing provides insight into the complexity and diversity of the Pinctada fucata martensii transcriptome
The pearl oyster Pinctada fucata martensii is an economically valuable shellfish for seawater pearl production, and production of pearls depends on its growth. To date, the molecular mechanisms of the growth of t...
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Article
Analysis of the clinical characteristics of thirteen patients with Weber-Christian panniculitis
Weber-Christian disease (WCD) is an uncommon, idiopathic disease that is challenging to diagnose and has an unclear treatment protocol. We reviewed thirteen patients with WCD and analyzed their clinical charac...
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Article
Comparative Capacity Assessment of CFRP Retrofit Techniques for RC Frames with Masonry Infills Using Pushover Analysis
In this study, nonlinear static pushover analysis was performed to compare the effectiveness of different carbon fibre-reinforced polymers (CFRP) rehabilitation schemes for existing masonry-infilled RC frames....
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Article
Seismic Fragility of a Typical Containment under Bidirectional Earthquake Excitations
Existing research to predict seismic fragility of Reinforced Concrete Containment (RCC) buildings does not take into account the impact of its inelastic bidirectional interaction arising from bidirectional hor...
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Article
Amplification factors for design of nonstructural components considering the near-fault pulse-like ground motions
This manuscript investigates the amplification factors for the design of nonstructural components for the near-fault pulse-like ground motions. The amplification factors are computed for the primary structure ...
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Article
Damage accumulation of a base-isolated RCC building under mainshock-aftershock seismic sequences
Strong aftershocks have the potential to induce greater structural damage for Nuclear Power Plant (NPP) structures. In order to ensure the safety and integrity of Reinforced Concrete Containment (RCC) building...
