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Article
Open AccessStudy on compaction characteristics and mechanical model of dry crushing filling material under lateral confinement condition
The compaction characteristics and bearing capacity of dry filling materials in goaf have a significant influence on stope control and surface stability. Through acoustic emission monitoring and mechanical mod...
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Article
Study on the Anti-scouring and Energy Absorption Characteristics of Coupled Broken Coal Rock Mass and Packed STFs
Considering certain issues such as the significant energy release during deep rock bursts, severe damage to roadway support systems, and compromised safety of miners, we aimed to address these problems through...
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Article
Optimization of linear plasmid expression system for protein production and secretion in Bacillus thuringiensis
Bacillus thuringiensis, a safe bacterium widely used in agriculture for the biocontrol of pests, has great potential for protein production. The linear plasmid expression system, bacterial orthogonal DNA replicat...
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Article
Open AccessAn MRI Study of Morphology, Asymmetry, and Sex Differences of Inferior Precentral Sulcus
Numerous studies utilizing magnetic resonance imaging (MRI) have observed sex and interhemispheric disparities in sulcal morphology, which could potentially underpin certain functional disparities in the human...
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Article
Carnosic acid nanocluster-based framework combined with PD-1 inhibitors impeded tumorigenesis and enhanced immunotherapy in hepatocellular carcinoma
Clinically, the immune checkpoint inhibitor anti-PD-1 antibody has shown a certain effect in the treatment of hepatocellular carcinoma (HCC), which is limited to a small number of patients with HCC. This study...
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Article
Engineered Saccharomyces cerevisiae for de novo δ-tocotrienol biosynthesis
As a vitamin E isomer, δ-tocotrienol has attracted much attention owing to its rich biological activities for human health, especially anticancer activities. Microbial biosynthesis constitutes a promising stra...
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Article
Engineering Bacillus subtilis for efficient production of 3′-sialyllactose
3′-Sialyllactose (3′-SL) promotes the proliferation of the bifidobacterial population and shapes gut microbiota. Thus, it can be used in the infant formula industry. In this study, an engineered Bacillus subtilis
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Article
Open AccessAngiogenesis modulated by CD93 and its natural ligands IGFBP7 and MMRN2: a new target to facilitate solid tumor therapy by vasculature normalization
The tumor vasculature was different from the normal vasculature in both function and morphology, which caused hypoxia in the tumor microenvironment (TME). Previous anti-angiogenesis therapy had led to a modest...
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Article
Combinatorial metabolic engineering enables high yield production of α-arbutin from sucrose by biocatalysis
α-Arbutin has been widely used as a skin-whitening ingredient. Previously, we successfully produced α-arbutin via whole-cell biocatalysis and found that the conversion rate of sucrose to α-arbutin was low (~45...
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Article
CRISPR–dCas12a-mediated genetic circuit cascades for multiplexed pathway optimization
The production efficiency of microbial cell factories is sometimes limited by the lack of effective methods to regulate multiple targets in a coordinated manner. Here taking the biosynthesis of glucosamine-6-p...
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Chapter and Conference Paper
Cross-view Geo-localization Based on Cross-domain Matching
As a recently emerging problem, cross-view geo-localization aims at finding image pairs captured from different views (e.g., drone and satellite views) or domains yet same location, which can be widely employe...
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Chapter and Conference Paper
Modeling and Analysis of Bidirectional Wireless Power Transfer System with Asymmetric Parameters
Bidirectional wireless power transfer technology can realize the non-contact bidirectional flow of electric energy between devices. Compared with unidirectional wireless charging and wired charging, it is more...
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Article
Design of Oil Shale In-Situ Extraction Heater Structure and Numerical Simulation of the Fracturing Process
Downhole continuous spiral folded plate heaters that generate high temperature air to heat oil shale are an efficient method of in-situ oil shale extraction. In this paper, the physical model of downhole conti...
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Article
Direction Optimization Model of Trenchless Horizontal Hole in Fractured Formation
Whether the hole is in safe state is quite essential in the construction technology of trenchless directional horizontal hole. Many consequences caused by hole wall instability will seriously affect the normal...
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Article
Characteristics of effervescent tablets of Aronia melanocarpa: response surface design and antioxidant activity evaluation
An effervescent tablet containing Aronia melanocarpa lyophilized powder was developed. The formulation was optimized by response surface method with the the central composite design design. The contents of total ...
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Article
Open AccessApplication of purse string suture pancreaticojejunostomy for undilated pancreatic duct in total laparoscopic pancreaticoduodenectomy
To investigate the feasibility of purse string suture pancreaticojejunostomy in complete laparoscopic pancreaticoduodenectomy for patients with an undilated pancreatic duct.
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Article
Six application scenarios of artificial intelligence in the precise diagnosis and treatment of liver cancer
The establishment of the precision diagnosis and treatment system and the advent of the digital intelligence era have not only deepened people's understanding of liver cancer but also continuously improved the...
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Article
Open AccessCirc_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis
Chemoresistance limits the therapeutic effect of cisplatin (DDP) on non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) function as important regulators in chemoresistance. This study aimed to explore...
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Article
Open AccessPoliovirus receptor (PVR)-like protein cosignaling network: new opportunities for cancer immunotherapy
Immune checkpoint molecules, also known as cosignaling molecules, are pivotal cell-surface molecules that control immune cell responses by either promoting (costimulatory molecules) or inhibiting (coinhibitory...
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Article
H∞ mixed sensitivity robust control method of relay ICPT system for output voltage regulation
Aiming at the problem that the output voltage of relay inductive coupled power transfer (ICPT) system is susceptible to changes due to the influence of system load changes, frequency perturbations, and input v...
