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Article
Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia
Androgenetic alopecia (AGA) is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment, leading to cell apoptosis and eventual loss of hair fol...
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Article
Open AccessEpigenetic addition of m5C to HBV transcripts promotes viral replication and evasion of innate antiviral responses
Eukaryotic five-methylcytosine (m5C) is an important regulator of viral RNA splicing, stability, and translation. However, its role in HBV replication remains largely unknown. In this study, functional m5C sites ...
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Article
Numerical and Experimental Study on the Fatigue Behavior of X80 Steel Treated by Biomimetic Laser Shock Peening
To clarify the influence of biomimetic laser shock peening (BLSP) on the fatigue crack propagation behavior of X80 steel, a three-dimensional BLSP finite element model is developed in this study. The effects o...
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Article
The effects of countersink depth on fatigue performance of CFRP joint
Countersink bolts are extensively utilized in aircraft connection structures due to their excellent connectivity performance. However, the occurrence of countersink depth errors is inevitable during the produc...
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Article
Open AccessHuman umbilical cord mesenchymal stromal cell small extracellular vesicle transfer of microRNA-223-3p to lung epithelial cells attenuates inflammation in acute lung injury in mice
Acute lung injury (ALI), manifested as strong pulmonary inflammation and alveolar epithelial damage, is a life-threatening disease with high morbidity and mortality. Small extracellular vesicles (sEVs), secret...
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Article
Open AccessEfficacy and safety of umbilical cord-derived mesenchymal stem cells in Chinese adults with type 2 diabetes: a single-center, double-blinded, randomized, placebo-controlled phase II trial
To determine the efficacy and safety of umbilical cord-derived mesenchymal stem cells (UC-MSCs) in Chinese adults with type 2 diabetes mellitus (T2DM).
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Article
Photocatalytic syngas synthesis from CO2 and H2O using ultrafine CeO2-decorated layered double hydroxide nanosheets under visible-light up to 600 nm
The rational design of photocatalyst that can effectively reduce CO2 under visible light (λ > 400 nm), and simultaneously precise control of the products syngas (CO/H2) ratio is highly desirable for the Fischer-T...
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Chapter and Conference Paper
Medical Data Crawling Algorithm Based on PageRank
In order to establish a database of characteristics related to physical conditions and then build a remote health intelligence-assisted diagnosis model based on the deep learning training mechanism, it is nece...
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Article
Open AccessDecitabine assists umbilical cord-derived mesenchymal stem cells in improving glucose homeostasis by modulating macrophage polarization in type 2 diabetic mice
Mesenchymal stem cells (MSCs) have emerged as a promising therapy for type 2 diabetes (T2D). Mechanistic researches demonstrate that the anti-diabetic effect of MSCs is partially mediated by eliciting macropha...
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Article
Open AccessHuman umbilical cord-derived mesenchymal stem cells direct macrophage polarization to alleviate pancreatic islets dysfunction in type 2 diabetic mice
Progressive pancreatic β-cell dysfunction is recognized as a fundamental pathology of type 2 diabetes (T2D). Recently, mesenchymal stem cells (MSCs) have been identified in protection of islets function in T2D...
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Article
Open AccessHuman umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance by suppressing NLRP3 inflammasome-mediated inflammation in type 2 diabetes rats
Insulin resistance is one of the most common and important pathological features of type 2 diabetes (T2D). Recently, insulin resistance is increasingly considered to be associated with systemic chronic inflamm...
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Article
Open AccessMesenchymal stem cell therapy in type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM), which is characterized by the combination of relative insulin deficiency and insulin resistance, cannot be reversed with existing therapeutic strategies. Transplantation of ins...
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Article
Open AccessMesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation
Clinical and experimental studies have highlighted the significance of inflammation in coordinating wound repair and regeneration. However, it remains challenging to control the inflammatory response and toler...
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Article
Open AccessGiant spin-torque diode sensitivity in the absence of bias magnetic field
Microwave detectors based on the spin-torque diode effect are among the key emerging spintronic devices. By utilizing the spin of electrons in addition to charge, they have the potential to overcome the theore...
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Article
Open AccessLPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b
Within the last few years, it has become evident that LPS-preconditioned mesenchymal stromal cells (LPS pre-MSCs) show enhanced paracrine effects, including increased trophic support and improved regenerative ...
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Article
Open AccessBeta-cell regeneration from vimentin+/MafB+ cells after STZ-induced extreme beta-cell ablation
Loss of functional beta-cells is fundamental in both type 1 and type 2 diabetes. In situ beta-cell regeneration therefore has garnered great interest as an approach to diabetes therapy. Here, after elimination of...
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Article
Open AccessThe role of the microenvironment on the fate of adult stem cells
Adult stem cells (SCs) exist in all tissues that promote tissue growth, regeneration, and healing throughout life. The SC niche in which they reside provides signals that direct them to proliferate, differenti...
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Article
Open AccessCharacterization of protein expression of Platanus pollen following exposure to gaseous pollutants and vehicle exhaust particles
Being major ornamental street trees, species of Platanus are widely planted in the Shanghai urban area. A great deal of allergenic Platanus pollen is released from the trees and suspended in the atmosphere during...
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Article
Open AccessTreatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth
Hair loss (alopecia) is a common problem for people. The dermal papilla is the key signaling center that regulates hair growth and it engage in crosstalk with the microenvironment, including Wnt signaling and ...
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Article
Electron spin resonance and spin–valley physics in a silicon double quantum dot
Silicon quantum dots are a leading approach for solid-state quantum bits. However, develo** this technology is complicated by the multi-valley nature of silicon. Here we observe transport of individual elect...
