54 Result(s)

Article

Correction: The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA

Ming Li, Zhongyu **e, Peng Wang, **teng Li, Wenjie Liu, Su’an Tang… in Cell Death & Disease (2024)

Article

Targeting CK2 eliminates senescent cells and prolongs lifespan in Zmpste24-deficient mice

Senescent cell clearance is emerging as a promising strategy for treating age-related diseases. Senolytics are small molecules that promote the clearance of senescent cells; however, senolytics are uncommon an...

Jie Zhang, Pengfei Sun, Zhu** Wu, Jie Wu, Jiali Jia, Haoman Zou… in Cell Death & Disease (2024)

Article

Research progress on morphology and mechanism of programmed cell death

Programmed cell death (PCD) is a basic process of life that is closely related to the growth, development, aging and disease of organisms and is one of the hotspots of life science research today. PCD is a kin...

Yao Chen, **aohua Li, Minfeng Yang, Song-Bai Liu in Cell Death & Disease (2024)

Article

LncRNA IL21-AS1 facilitates tumour progression by enhancing CD24-induced phagocytosis inhibition and tumorigenesis in ovarian cancer

CD24 is overexpressed in various tumours and considered a regulator of cell migration, invasion, and proliferation. Recent studies have found that CD24 on ovarian cancer (OC) and triple-negative breast cancer ...

Jie Liu, Changsheng Yan, Shaohua Xu in Cell Death & Disease (2024)

Article

Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo

During the maturation of hematopoietic stem/progenitor cells (HSPCs) to fully differentiated mature B lymphocytes, develo** lymphocytes may undergo malignant transformation and produce B-cell lymphomas. Emer...

Zhaohua Cai, Shao** You, Zhixue Liu, ** Song, Fujie Zhao… in Cell Death & Disease (2024)

Article

Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells

Dysregulation of anti-apoptotic and pro-apoptotic protein isoforms arising from aberrant splicing is a crucial hallmark of cancers and may contribute to therapeutic resistance. Thus, targeting RNA splicing to ...

Zhihui Dou, Huiwen Lei, Wei Su, Taotao Zhang, **aohua Chen, Boyi Yu… in Cell Death & Disease (2024)

Article

Correction: Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinoma

Chan **ang, Min Zhang, Zhanxian Shang, Shengnan Chen, Jikai Zhao… in Cell Death & Disease (2024)

Article

Targeting FBXO22 enhances radiosensitivity in non-small cell lung cancer by inhibiting the FOXM1/Rad51 axis

Radioresistance is a major constraint on the efficacy of lung cancer radiotherapy, but its mechanism has not been fully elucidated. Here, we found that FBXO22 was aberrantly highly expressed in lung cancer and...

Yunshang Chen, Yun Zhou, Xue Feng, Zilong Wu, Yongqiang Yang… in Cell Death & Disease (2024)

Article

METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner

Acute lung injury (ALI) as well as its more severe form, acute respiratory distress syndrome (ARDS), frequently leads to an uncontrolled inflammatory response. N⁶-methyladenosine (m⁶A) modification was associated...

Fei Cao, Guojun Chen, Yixin Xu, **ntong Wang, **aole Tang… in Cell Death & Disease (2024)

Article

Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinoma

An immunosuppressive microenvironment enriched with regulatory CD4⁺ T lymphocytes (Tregs) facilitates the progression of lung adenocarcinoma (LUAD). This study aims to investigate the cellular mechanism underlyin...

Chan **ang, Min Zhang, Zhanxian Shang, Shengnan Chen, Jikai Zhao… in Cell Death & Disease (2023)

Article

Gasdermin D-mediated pyroptosis is regulated by AMPK-mediated phosphorylation in tumor cells

Gasdermin D (GSDMD) is a critical mediator of pyroptosis, which consists of a N-terminal pore-forming domain and a C-terminal autoinhibitory domain. Its cytolytic activity is sequestered by the intramolecular ...

**ufeng Chu, **ang **ao, Guangchuan Wang, Ahmed Uosef, **aohua Lou… in Cell Death & Disease (2023)

Article

Anastasis enhances metastasis and chemoresistance of colorectal cancer cells through upregulating cIAP2/NFκB signaling

Chemotherapy is a common strategy to treat cancer. However, acquired resistance and metastasis are the major obstacles to successful treatment. Anastasis is a process by which cells survive executioner caspase...

Ru Wang, Yuxing Wang, **aohe Liu, Menghao Liu, Lili Sun… in Cell Death & Disease (2023)

Article

SLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis

Keratinocyte hyperproliferation is a key pathogenic factor in psoriasis. However, the mechanisms that regulate keratinocyte hyperproliferation in this condition remain unclear. Here, we found that SLC35E1 was ...

Tao Huang, Shijun Chen, Ke Ding, Baoqing Zheng, Weiqi Lv… in Cell Death & Disease (2023)

Article

Correction: TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α

**aohua Lei, Qiang Liu, Wei Qin, Qing Tong, Zhenghao Li, Wendi Xu… in Cell Death & Disease (2023)

Article

Litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut-lung axis immunotherapy

Litchi chinensis seed, as a valuable by-product of the subtropical fruit litchi (Litchi chinensis Sonn.), has been confirmed to be rich in procyanidins (LPC). The anticarcinogenic properties of procyanidins has b...

Yuan Yao, Suya Feng, Xuejiao Li, Taohua Liu, Shengying Ye, Long Ma… in Cell Death & Disease (2023)

Article

TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α

Impairment of liver regeneration leads to severe morbidity in acute and chronic severe liver disease. Transient receptor potential melastain 8 (TRPM8) is involved in a variety of processes, including temperatu...

**aohua Lei, Qiang Liu, Wei Qin, Qing Tong, Zhenghao Li, Wendi Xu… in Cell Death & Disease (2022)

Article

SMOC2 promotes aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis through transcriptional and post-transcriptional regulating MYO1C

Fibroblast-like synoviocytes (FLSs), play a key role in perpetuating synovial inflammation and bone erosion in rheumatoid arthritis (RA), however, the underlying mechanism(s) of RA FLSs activation and aggressi...

Di Liu, Ruiru Li, Siqi Xu, Maohua Shi, Yu Kuang, **gnan Wang… in Cell Death & Disease (2022)

Article

USP36 facilitates esophageal squamous carcinoma progression via stabilizing YAP

Esophageal squamous carcinoma (ESCC) is the major subtype of esophageal cancer in China, accounting for 90% of cases. Recent studies revealed that abnormalities in the Hippo/YAP axis are pervasive in ESCC and ...

Wenhao Zhang, Junwen Luo, Zhaohua **ao, Yifeng Zang, **n Li… in Cell Death & Disease (2022)

Article

Mutant p53 in cancer: from molecular mechanism to therapeutic modulation

TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often acquires inherent, novel oncogenic functions, ...

**aohua Chen, Taotao Zhang, Wei Su, Zhihui Dou, Dapeng Zhao… in Cell Death & Disease (2022)

Article

NLRP6 is required for cancer-derived exosome-modified macrophage M2 polarization and promotes metastasis in small cell lung cancer

Metastasis remains the primary cause of small cell lung cancer (SCLC)-related deaths. Growing evidence links tumor metastasis with a pre-metastatic microenvironment characterized by an anti-inflammatory respon...

**nrui Rao, **aoshu Zhou, Geng Wang, **aohua Jie, Biyuan **ng… in Cell Death & Disease (2022)