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Article
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Energy metabolism has always been a hot topic in cancer progression and targeted therapy, and exploring the role of genes in energy metabolic pathways in cancer cells has become key to address this issue. Euka...
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Ultrathin GaN Film Derived from Amorphous Ga2O3 Film
It remains a big challenge to synthesize two-dimensional (2D) GaN material for applications in power nanodevices. Traditional synthetic methods require complex equipment and processes and time consuming. Here,...
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Mechanical Response and Failure Mechanism of AFRP-repaired Corroded CHS Tubes Under Axial Compression
Corrosion-induced defects, extensive and unavoidable in marine structures, pose significant threats to structural integrity and safety. This study aims to assess mechanical response and investigate the failure...
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T-Type Digraphs via Kronecker Canonical Form
In this paper, the authors aim to study Kronecker canonical form theory for T-type digraphs, which can be used to construct trees by tensor product with some directed paths. Firstly, the authors show that some...
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Open AccessNecroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma
Airway epithelial cell (AEC) necroptosis contributes to airway allergic inflammation and asthma exacerbation. Targeting the tumor necrosis factor-like ligand 1 A (TL1A)/death receptor 3 (DR3) axis has a therap...
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Open AccessConstraining ultralight dark matter through an accelerated resonant search
Typical weak signal search experiments rely on resonant effects, where the resonance frequency is scanned over a broad range, resulting in significant time consumption. In this study, we demonstrate an acceler...
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Open AccessPan-cancer analysis and the oncogenic role of Glypican 1 in hepatocellular carcinoma
Recent studies indicate that Glypican 1 (GPC-1) is aberrantly expressed and plays a key role in certain cancers, but little is known in the hepatocellular carcinoma. Raw data from TCGA, GTEx and TIMER database...
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Open AccessInvestigation of prognostic values of immune infiltration and LGMN expression in the microenvironment of osteosarcoma
Osteosarcoma (OS), the most common primary malignant bone tumor, predominantly affects children and young adults and is characterized by high invasiveness and poor prognosis. Despite therapeutic advancements, ...
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Open AccessPerturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging
Cellular senescence is characterized by a decrease in protein synthesis, although the underlying processes are mostly unclear. Chemical modifications to transfer RNAs (tRNAs) frequently influence tRNA activity...
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Regulation of photophysical and electronic properties of I–III–VI quantum dots for light-emitting diodes
Quantum dot light-emitting diodes (QLEDs) have become an important research direction in the pursuit of next-generation display technology owing to their favorable attributes, including high energy efficiency,...
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Open AccessMachine learning models to predict systemic inflammatory response syndrome after percutaneous nephrolithotomy
The objective of this study was to develop and evaluate the performance of machine learning models for predicting the possibility of systemic inflammatory response syndrome (SIRS) following percutaneous nephro...
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Open AccessWorking with AI: the impact of organizational intelligent service strategy on employees’ perception of career achievement
In the artificial intelligence (AI) environment, there is limited research on employees’ perception of career achievement. Previous literature has presented two different viewpoints: AI either reduces or incre...
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A randomized block Douglas–Rachford method for solving linear matrix equation
The Douglas-Rachford method (DR) is one of the most computationally efficient iterative methods for the large scale linear systems of equations. Based on the randomized alternating reflection and relaxation st...
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Effects of ionic strength and bentonite ratio on the migration of Cr(VI) in clayey soil-bentonite engineered barrier
Soil-bentonite (S-B) barriers have been widely used for heavy metal pollution containment. This study conducted batch adsorption tests and diffusion-through tests to evaluate how ionic strength and bentonite r...
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Open AccessAdvances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases
Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis remain unclear. Currently, increasing research has highlighted the role of ferroptosis in immune regulation, with immune...
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Open AccessCRISPR-Cas3 and type I restriction-modification team up against blaKPC-IncF plasmid transfer in Klebsiella pneumoniae
We explored whether the Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas and restriction-modification (R-M) systems are compatible and act together to resist plasmid attacks.
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Preparation, Curing and Properties of Liquid Amine-Terminated Fluoroelastomers
A two-step nucleophilic substitution mechanism was used and described to prepare liquid amine-terminated fluoroelastomers (LTAFs) by using liquid hydroxy-terminated fluoroelastomers (LTHFs) as raw materials, b...
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Open AccessZona incerta mediates early life isoflurane-induced fear memory deficits
The potential long-term effects of anesthesia on cognitive development, especially in neonates and infants, have raised concerns. However, our understanding of its underlying mechanisms and effective treatment...
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Enhancing conductivity of Si anode enabled by selecting Si particle size for interface stabilized all-solid-state batteries
Silicon (Si) particle with small size used as anode material has been recognized for its ability to reduce the damage caused by volume expansion in liquid lithium-ion batteries. However, whether the same mecha...
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High-resolution tsunami hazard assessment for the Guangdong-Hong Kong-Macao Greater Bay Area based on a non-hydrostatic tsunami model
The Guangdong-Hong Kong-Macao Greater Bay Area (GBA) is threatened by potential tsunami hazards from the Littoral Fault Zone (LFZ) and the Manila subduction zone (MSZ), and may suffer huge damage because of it...
