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Article
Open AccessUsing Portuguese BRCA pathogenic variation as a model to study the impact of human admixture on human health
Admixture occurs between different ethnic human populations. The global colonization in recent centuries by Europeans led to the most significant admixture in human history. While admixture may enhance genetic...
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Article
Open AccessPathogenic variants in human DNA damage repair genes mostly arose in recent human history
Genome stability is maintained by the DNA damage repair (DDR) system composed of multiple DNA repair pathways of hundreds of genes. Germline pathogenic variation (PV) in DDR genes damages function of the affec...
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Article
Open AccessPorous Carbon Architecture Assembled by Cross-Linked Carbon Leaves with Implanted Atomic Cobalt for High-Performance Li–S Batteries
SiO2-mediated ZIF-L is developed to prepare Co–N4@2D/3D carbon.
Co–N4@2D/3D integrates the advant...
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Article
Open AccessAn RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness
Notch signaling represents a key mechanism mediating cancer metastasis and stemness. To understand how Notch signaling is overactivated to couple tumor metastasis and self-renewal in NSCLC cells, we performed ...
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Article
Open AccessForward and reverse mutations in stages of cancer development
Massive occurrences of interstitial loss of heterozygosity (LOH) likely resulting from gene conversions were found by us in different cancers as a type of single-nucleotide variations (SNVs), comparable in abu...
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Article
Ultra-sensitive film sensor based on Al2O3–Au nanoparticles supported on PDDA-functionalized graphene for the determination of acetaminophen
An electrochemical sensor of acetaminophen based on poly(diallyldimethylammonium chloride) (PDDA)-functionalized reduced graphene-loaded Al2O3–Au nanoparticles coated onto glassy carbon electrode (Al2O3–Au/PDDA/r...
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Article
Open AccessMassive interstitial copy-neutral loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response
The presence of loss-of-heterozygosity (LOH) mutations in cancer cell genomes is commonly encountered. Moreover, the occurrences of LOHs in tumor suppressor genes play important roles in oncogenesis. However, ...
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Article
KfoE encodes a fructosyltransferase involved in capsular polysaccharide biosynthesis in Escherichia coli K4
Escherichia coli K4 synthesizes a capsular polysaccharide (CPS) consisting of a fructose-branched chondroitin (GalNAc-GlcA(fructose)n), which is a biosynthetic precursor of chondroitin sulfate. H...
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Article
Open AccessAluScan: a method for genome-wide scanning of sequence and structure variations in the human genome
To complement next-generation sequencing technologies, there is a pressing need for efficient pre-sequencing capture methods with reduced costs and DNA requirement. The Alu family of short interspersed nucleot...
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Article
Amino acid sequence analysis and identification of mutations under positive selection in hemagglutinin of 2009 influenza A (H1N1) isolates
The 2009 flu pandemic is caused by a new strain of influenza A (H1N1) virus, A/H1N1/09. With its high transmissibility, this novel virus has caused a pandemic and infected over 600,000 people globally. By comp...
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Article
microRNA and Cancer
MicroRNAs (miRNAs), a class of small, regulatory, non-coding RNA molecules, display aberrant expression patterns and functional abnormalities in human diseases including cancers. This review summarizes the abn...
