278 Result(s)
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Life Sciences
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Article
Open AccessEndothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance
Obesity and exercise intolerance greatly reduce the life quality of older people. Prolyl hydroxylase domain-containing protein 2 (PHD2) is an important enzyme in modulating hypoxia-inducible factor-alpha (HIF)...
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Open AccessMycobacterium tuberculosis produces d-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice
Adaptation to hypoxia is a major challenge for the survival of Mycobacterium tuberculosis (Mtb) in vivo. Interferon (IFN)-γ-producing CD8+ T cells contribute to control of Mtb infection, in part by promoting anti...
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A hypothetical model of phytoremediation for bioremediation of heavy metals toxicity in agricultural system
Heavy metals contamination in agricultural soils has become a significant concern due to its detrimental effects on crop growth, productivity and food safety. Understanding the sources of heavy metals and impl...
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Effects of the Concentrations of Nitrogen Supplied From Both or One-Half of the Dual-Root System on the Nitrogen Fixation of Soybean Nodules and the Distribution of Absorbed Nitrogen From Roots
This study aimed to investigate the effects of the different concentrations of ammonium or nitrate supplied from both or one-half of the dual-root system on the nitrogen fixation of soybean nodules and the dis...
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Open AccessSMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2− breast cancer
Endocrine resistance poses a significant clinical challenge for patients with hormone receptor-positive and human epithelial growth factor receptor 2-negative (HR + HER2−) breast cancer. Dysregulation of estro...
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Open AccessIdentification and molecular map** of resistance genes for adult-plant resistance to stripe rust in spring wheat germplasm line PI660076
Wheat is one of the major food crops worldwide. Stripe rust can cause a great loss of wheat yield, especially when the disease is prevalent. Chemical control not only causes the loss of resistance to stripe ru...
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The multimodality cell segmentation challenge: toward universal solutions
Cell segmentation is a critical step for quantitative single-cell analysis in microscopy images. Existing cell segmentation methods are often tailored to specific modalities or require manual interventions to ...
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Open AccessAll-trans retinoic acid pretreatment of mesenchymal stem cells enhances the therapeutic effect on acute kidney injury
A promising new therapy option for acute kidney injury (AKI) is mesenchymal stem cells (MSCs). However, there are several limitations to the use of MSCs, such as low rates of survival, limited homing capacity,...
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Open AccessscCDC: a computational method for gene-specific contamination detection and correction in single-cell and single-nucleus RNA-seq data
In droplet-based single-cell and single-nucleus RNA-seq assays, systematic contamination of ambient RNA molecules biases the quantification of gene expression levels. Existing methods correct the contamination...
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Open AccessProtein expression patterns and metal metabolites in a protogynous hermaphrodite fish, the ricefield eel (Monopterus albus)
The ricefield eel Monopterus albus undergoes a natural sex change from female to male during its life cycle, and previous studies have shown the potential mechanisms of this transition at the transcriptional and ...
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Article
Pivotal role for long noncoding RNAs in zygotic genome activation in mice
Vertebrate life begins with fertilization, and then the zygote genome is activated after transient silencing, a process termed zygotic genome activation (ZGA). Despite its fundamental role in totipotency and t...
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Decreased LTBP2 expression inhibits proliferation and migration of glioma
Glioblastoma (GBM) is the most aggressive form of glioma. However, the treatment of GBM remains largely ineffective. LTBP2 is a secreted extracellular matrix protein involved in the progression of multiple tum...
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Open AccessMiR-134-5p inhibits the malignant phenotypes of osteosarcoma via ITGB1/MMP2/PI3K/Akt pathway
Micro RNAs (miRs) have been implicated in various tumorigenic processes. Osteosarcoma (OS) is a primary bone malignancy seen in adolescents. However, the mechanism of miRs in OS has not been fully demonstrated...
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Open AccessIntegrated analysis of single-cell and bulk RNA sequencing data reveals prognostic characteristics of lysosome-dependent cell death-related genes in osteosarcoma
Tumor cells exhibit a heightened susceptibility to lysosomal-dependent cell death (LCD) compared to normal cells. However, the role of LCD-related genes (LCD-RGs) in Osteosarcoma (OS) remains unelucidated. Thi...
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Open AccessUnsupervised deep representation learning enables phenotype discovery for genetic association studies of brain imaging
Understanding the genetic architecture of brain structure is challenging, partly due to difficulties in designing robust, non-biased descriptors of brain morphology. Until recently, brain measures for genome-w...
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Open AccessAssociation of birth weight with type 2 diabetes mellitus and the mediating role of fatty acids traits: a two-step mendelian randomization study
Observational studies have suggested an association between birth weight and type 2 diabetes mellitus, but the causality between them has not been established. We aimed to obtain the causal relationship betwee...
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Effects of different ecological restoration methods on the soil bacterial community structure of a light rare earth tailings pond
The characteristics of microbial communities can directly reflect the physicochemical properties of soil which is important for successful ecological restoration in the tailings pond.
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Open AccessMycobacterium tuberculosis inhibits METTL14-mediated m6A methylation of Nox2 mRNA and suppresses anti-TB immunity
Internal N6-methyladenosine (m6A) modifications are among the most abundant modifications of messenger RNA, playing a critical role in diverse biological and pathological processes. However, the functional role a...
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Open AccessCombined metagenomics and metabolomic analysis of microbial community structure and metabolic function in continuous soybean crop** soils of Songnen Plain, China
Continuous crop** has a negative effect on soybean yield. In this study, a positioning experiment was conducted starting in 2015, with three treatments: maize–soybean rotation (SMR), 2-year maize, 2-year soy...
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Open AccessGenome-wide identification analysis of the 4-Coumarate: CoA ligase (4CL) gene family expression profiles in Juglans regia and its wild relatives J. Mandshurica resistance and salt stress
Persian walnut (Juglans regia) and Manchurian walnut (Juglans mandshurica) belong to Juglandaceae, which are vulnerable, temperate deciduous perennial trees with high economical, ecological, and industrial values...
