57 Result(s)
within
**ao-yu Zhao
Biomedicine, general
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Article
Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4
Nasopharyngeal carcinoma (NPC) occurs with high frequency in Asian populations, especially among people of Cantonese ancestry. In areas with high incidence, NPC clusters in families, which suggests that both g...
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Article
Construction of phospholamban antisense RNA recombinant adeno-associated virus vector and its effects in rat cardiomyocytes
To construct a recombinant adeno-associated virus (rAAV) vector containing gene encoding phospholamban antisense RNA (asPLB), and analyse its effect on expression of PLB, expression and activity of sarco-endop...
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Article
Correlation of serum arylesterase activity on phenylacetate estimated by the integrated method to common classical biochemical indexes of liver damage
The correlation of serum arylesterase (PON1) activity on phenylacetate determined by an integrated method to classical biochemical indexes of liver damage was investigated for the use of PON1 activity to evalu...
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Article
Antiproliferative effect of rapamycin on human T-cell leukemia cell line Jurkat by cell cycle arrest and telomerase inhibition
To examine the ability of rapamycin to suppress growth and regulate telomerase activity in the human T-cell leukemia cell line Jurkat.
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Article
Purification and characterization of a novel antifungal protein from Bacillus subtilis strain B29
An antifungal protein was isolated from a culture of Bacillus subtilis strain B29. The isolation procedure comprised ion exchange chromatography on diethylaminoethyl (DEAE)-52 cellulose and gel filtration chromat...
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Article
Open AccessTranscriptional activation of insulin-like growth factor binding protein 6 by 17β-estradiol in SaOS-2 cells
Osteoblasts can synthesize the insulin-like growth factors (IGFs) and the IGF-binding proteins (IGFBPs), which may either enhance or attenuate IGF-stimulated bone cell proliferation. Since estrogen induced ost...
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Article
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
Xuejun Zhang and colleagues report results of a genome-wide association study of systemic lupus erythematosus (SLE) in a Chinese Han population. Their work identifies nine new SLE susceptibility loci and revea...
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Article
The dual role of osteopontin in acetaminophen hepatotoxicity
Osteopontin (OPN), a multifunctional protein, has been reported to be protoxicant in acetaminophen hepatotoxicity. In this study, the mechanisms underlying the detrimental role of OPN in acetaminophen toxicity...
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Article
Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis
Xue-Jun Zhang, Jun Wang and colleagues identify mutations in MVK in disseminated superficial actinic porokeratosis, a disorder characterized by defects in epidermal keratinization. MVK encodes mevalonate kinase, ...
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Article
Open AccessmiR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells
Androgen receptor (AR) signalling is critical to the initiation and progression of prostate cancer (PCa). Transcriptional activity of AR involves chromatin recruitment of co-activators, including the p300/CBP-...
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Article
A correlation between acute kidney injury and myonecrosis after scheduled percutaneous coronary intervention
Slight elevations in cardiac troponin I and T are frequently observed after percutaneous coronary intervention (PCI). Contrast-induced acute kidney injury (CI-AKI) is a complex syndrome induced by exposure to ...
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Article
Identification of a novel frameshift mutation in PITX2 gene in a Chinese family with Axenfeld-Rieger syndrome
Objective: Axenfeld-Rieger syndrome (ARS) is phenotypically and genetically heterogeneous. In this study, we identified the underlying genetic defect in a Chinese family with ARS. Methods: A detailed family hi...
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Article
Protective effects of the novel adenosine derivative WS0701 in a mouse model of posttraumatic stress disorder
To investigate the effects of the novel N6-substituted adenosine derivative {(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-[(4-hydroxy-3-methoxybenzyl)amino]-9H-purin-9-yl]tetrahydrofuran-2-yl} methyl decanoate (WS0701) on st...
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Article
Transfer of the IL-37b gene elicits anti-tumor responses in mice bearing 4T1 breast cancer
IL-37b has shown anti-cancer activities in addition to its anti-inflammatory properties. In this study, we investigated the effects of IL-37b on breast carcinoma growth in mice and to determine the involvement...
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Article
Open AccessTranscutaneous auricular vagus nerve stimulation for pediatric epilepsy: study protocol for a randomized controlled trial
Recently, clinical observations reported the potential benefit of vagus nerve stimulation (VNS) for pediatric epilepsy. Transcutaneous auricular vagus nerve stimulation (ta-VNS) is a newer non-invasive VNS, ma...
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Article
Open AccessEffect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters
Berberine (BBR), as a new medicine for hyperlipidemia, can reduce the blood lipids in patients. Mechanistic studies have shown that BBR activates the extracellular-signal regulated kinase pathway by stabilizin...
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Article
Open AccessSLC39A6: a potential target for diagnosis and therapy of esophageal carcinoma
Esophageal squamous cell carcinoma (ESCC) is a highly lethal cancer, and its underlying molecular mechanisms are poorly understood. Recent large-scale genome-wide association studies in Chinese Han populations...
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Article
Open AccessCancer incidence in patients with type 2 diabetes mellitus: a population-based cohort study in Shanghai
Type 2 diabetes mellitus (T2DM) has been suggested to increase the risk of cancers. The aim of this study was to investigate the risk of common cancers in Chinese patients with T2DM.
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Article
Open AccessThe impact of the cumulative dose of cisplatin during concurrent chemoradiotherapy on the clinical outcomes of patients with advanced-stage nasopharyngeal carcinoma in an era of intensity-modulated radiotherapy
The impact of cumulative dose of cisplatin on clinical outcomes of nasopharyngeal carcinoma (NPC) patients who received intensity-modulated radiotherapy (IMRT) was evaluated.
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Article
The Syntheses, Structures, Fluorescence Properties and Biological Activity of two Novel Zinc(II) Complexes Controlled by the Tripodal Imidazole Ligand
Two new zinc complexes, namely Zn(L1)ClCH2NO(1) and {Zn(L2)CH2NO}n▪N(CH3)3▪ClO4(2) (L1 = 3,5-di(1H-imidazol-1-yl)pyridine L2 = 1,3,5-tris(1-imidazolyl) benzene), have been synthesized, and characterized by IR spe...
