81 Result(s)
within
**ao-ying Chen
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessMitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype
Bacterial genotoxins damage host cells by targeting their chromosomal DNA. In the present study, we demonstrate that a genotoxin of Salmonella Typhi, typhoid toxin, triggers the senescence-associated secretory ph...
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Open AccessAddendum: Cellular differentiation into hyphae and spores in halophilic archaea
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Open AccessToripalimab plus capecitabine in the treatment of patients with residual nasopharyngeal carcinoma: a single-arm phase 2 trial
Patients with residual nasopharyngeal carcinoma after receiving definitive treatment have poor prognoses. Although immune checkpoint therapies have achieved breakthroughs for treating recurrent and metastatic ...
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Open AccessMacro CD5L+ deteriorates CD8+T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma
Intratumoral immune status influences tumor therapeutic response, but it remains largely unclear how the status determines therapies for patients with intrahepatic cholangiocarcinoma. Here, we examine the sing...
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Open AccessMachine learning-based prediction model for myocardial ischemia under high altitude exposure: a cohort study
High altitude exposure increases the risk of myocardial ischemia (MI) and subsequent cardiovascular death. Machine learning techniques have been used to develop cardiovascular disease prediction models, but no...
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Open AccessProgrammable adhesion and morphing of protein hydrogels for underwater robots
Soft robots capable of efficiently implementing tasks in fluid-immersed environments hold great promise for diverse applications. However, it remains challenging to achieve robotization that relies on dynamic ...
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Open AccessMaternal dominance contributes to subgenome differentiation in allopolyploid fishes
Teleost fishes, which are the largest and most diverse group of living vertebrates, have a rich history of ancient and recent polyploidy. Previous studies of allotetraploid common carp and goldfish (cyprinids)...
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Open AccessTransfer learning with CNNs for efficient prostate cancer and BPH detection in transrectal ultrasound images
Early detection of prostate cancer (PCa) and benign prostatic hyperplasia (BPH) is crucial for maintaining the health and well-being of aging male populations. This study aims to evaluate the performance of tr...
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Open AccessGut microbial structural variation associates with immune checkpoint inhibitor response
The gut microbiota may have an effect on the therapeutic resistance and toxicity of immune checkpoint inhibitors (ICIs). However, the associations between the highly variable genomes of gut bacteria and the ef...
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Open AccessClinical outcomes between elderly ESKD patients under peritoneal dialysis and hemodialysis: a national cohort study
With ageing populations, new elderly end-stage kidney disease (ESKD) cases rise. Unlike younger patients, elderly ESKD patients are less likely to undergo kidney transplant, and therefore the decision of recei...
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Open AccessLILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis
Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) and its human ortholog recept...
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Open AccessAge-related self-DNA accumulation may accelerate arthritis in rats and in human rheumatoid arthritis
The incidence of rheumatoid arthritis (RA) is increasing with age. DNA fragments is known to accumulate in certain autoimmune diseases, but the mechanistic relationship among ageing, DNA fragments and RA patho...
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Open AccessHigh-throughput and high-accuracy single-cell RNA isoform analysis using PacBio circular consensus sequencing
Although long-read single-cell RNA isoform sequencing (scISO-Seq) can reveal alternative RNA splicing in individual cells, it suffers from a low read throughput. Here, we introduce HIT-scISOseq, a method that ...
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Open AccessEffect of a novel telehealth device for dietary cognitive behavioral intervention in overweight or obesity care
Obesity has become a major public health issue which relate to numerous physical problems and highly comorbid with depression and anxiety. Recently, some studies of technology-based interventions for weight re...
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Open AccessStructure of the heterotrimeric membrane protein complex FtsB-FtsL-FtsQ of the bacterial divisome
The synthesis of the cell-wall peptidoglycan during bacterial cell division is mediated by a multiprotein machine, called the divisome. The essential membrane protein complex of FtsB, FtsL and FtsQ (FtsBLQ) is...
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Open AccessCellular differentiation into hyphae and spores in halophilic archaea
Several groups of bacteria have complex life cycles involving cellular differentiation and multicellular structures. For example, actinobacteria of the genus Streptomyces form multicellular vegetative hyphae, aer...
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Open AccessContinuous exposure to isoprenaline reduced myotube size by delaying myoblast differentiation and fusion through the NFAT-MEF2C signaling pathway
We aimed to explore whether superfluous sympathetic activity affects myoblast differentiation, fusion, and myofiber types using a continuous single-dose isoprenaline exposure model in vitro and to further conf...
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Open AccessCircular polarized light-dependent anomalous photovoltaic effect from achiral hybrid perovskites
Circular polarized light-dependent anomalous bulk photovoltaic effect - a steady anomalous photovoltaic current can be manipulated by changing the light helicity, is an increasingly interesting topic in contex...
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Open AccessGPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation
Neutrophils play essential anti-microbial and inflammatory roles in host defense, however, their activities require tight regulation as dysfunction often leads to detrimental inflammatory and autoimmune diseas...
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Open AccessRanking the environmental factors of indoor air quality of metropolitan independent coffee shops by Random Forests model
Independent coffee shops are the alternative workplaces for people working remotely from traditional offices but are not concerned about their indoor air quality (IAQ). This study aimed to rank the environment...
