76 Result(s)
within
**ao-yi Chen
Life Sciences
-
Article
Author Correction: High-yield porphyrin production through metabolic engineering and biocatalysis
-
Article
Open AccessIn vitro and in vivo studies on exogenous polyamines and α-difluoromethylornithine to enhance bone formation and suppress osteoclast differentiation
Exogenous polyamines, including putrescine (PUT), spermidine (SPD), and spermine (SPM), and the irreversible inhibitor of the rate-limiting enzyme ornithine decarboxylase (ODC) of polyamine biosynthesis, α-dif...
-
Article
Open AccessGenome-wide expression analysis of vegetative organs during developmental and herbicide-induced whole plant senescence in Arabidopsis thaliana
Whole plant senescence represents the final stage in the life cycle of annual plants, characterized by the decomposition of aging organs and transfer of nutrients to seeds, thereby ensuring the survival of nex...
-
Article
High-yield porphyrin production through metabolic engineering and biocatalysis
Porphyrins and their derivatives find extensive applications in medicine, food, energy and materials. In this study, we produced porphyrin compounds by combining Rhodobacter sphaeroides as an efficient cell facto...
-
Article
Open AccessLeptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia
-
Article
Three stilbenes from pigeon pea with promising anti-methicillin-resistant Staphylococcus aureus biofilm formation activity
Cajaninstilbene acid (CSA), longistylin A (LLA), and longistylin C (LLC) are three characteristic stilbenes isolated from pigeon pea. The objective of this study was to evaluate the antibacterial activity of t...
-
Article
Open AccessMCL1 inhibition: a promising approach to augment the efficacy of sorafenib in NSCLC through ferroptosis induction
Ferroptosis, an iron-dependent form of regulated cell death, plays a crucial role in modulating the therapeutic response in non-small cell lung cancer (NSCLC) patients. Studies have identified the signal trans...
-
Article
Open AccessmiR-277 targets the proapoptotic gene-hid to ameliorate Aβ42-mediated neurodegeneration in Alzheimer’s model
Alzheimer’s disease (AD), an age-related progressive neurodegenerative disorder, exhibits reduced cognitive function with no cure to date. One of the reasons for AD is the accumulation of Amyloid-beta 42 (Aβ42...
-
Article
Open AccessTargeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis
Idiopathic pulmonary fibrosis is a progressive fibrotic disorder with no cure that is characterized by deterioration of lung function. Current FDA-approved drugs for IPF delay the decline in lung function, but...
-
Article
Open AccessPopulation genomic analysis provides evidence of the past success and future potential of South China tiger captive conservation
Among six extant tiger subspecies, the South China tiger (Panthera tigris amoyensis) once was widely distributed but is now the rarest one and extinct in the wild. All living South China tigers are descendants of...
-
Chapter
Transitional Coral Ecosystem of Taiwan in the Era of Changing Climate
The transitional coral ecosystem of Taiwan features tropical and temperate scleractinian coral species and suboptimal environmental conditions. As the largest continental island in the region, Taiwan is propos...
-
Article
Open AccessRevealing the characteristics of ZIKV infection through tissue-specific transcriptome sequencing analysis
Recently, Zika virus (ZIKV) re-emerged in India and was potentially associated with microcephaly. However, the molecular mechanisms underlying ZIKV pathogenesis remain to be explored.
-
Article
Open AccessIntegrative and comparative single-cell analysis reveals transcriptomic difference between human tumefactive demyelinating lesion and glioma
Tumefactive demyelinating lesion (TDL) is an immune-mediated disease which can be misdiagnosed as glioma. At present, there is no study comparing difference between the two disorders at the cellular level. Her...
-
Article
Validity Analysis of the Morphological Identification of Three Highly Morphologically Similar Species Belonging to the Genus Niviventer (Rodentia: Muridae)
Cryptic species are prevalent among mammals, and identifying morphological methods or measurements that can effectively distinguish cryptic species has high significance in taxonomy. Three of the white-bellied...
-
Article
Open AccessMelatonin enhances autologous adipose-derived stem cells to improve mouse ovarian function in relation to the SIRT6/NF-κB pathway
Premature ovarian insufficiency (POI) is the main cause of female infertility. Adipose-derived stem cells (ADSCs) are ideal candidates for the treatment of POI. However, some deficient biological characteristi...
-
Article
Description of Aureibaculum luteum sp. nov. and Aureibaculum flavum sp. nov. isolated from Antarctic intertidal sediments
Two Gram-stain-negative, aerobic, non-motile, and rod-shaped bacterial strains, designated SM1352T and A20T, were isolated from intertidal sediments collected from King George Island, Antarctic. They shared 99.8%...
-
Article
Open AccessEvaluation of the real-time fluorescence loop-mediated isothermal amplification assay for the detection of Ureaplasma urealyticum
Ureaplasma urealyticum (UU) is commonly present in human reproductive tract, which frequently leads to genital tract infection. Hence, there is an urgent need to develop a rapid detection method for UU. In our st...
-
Article
What is for dessert? Crown-of-thorns starfish feeds on non-scleractinian anthozoans at Tai** Island (Itu Aba), Spratlys, South China Sea
-
Article
MicroRNAs as biomarkers and perspectives in the therapy of pancreatic cancer
Pancreatic cancer is considered as one of the most aggressive tumor types, representing over 45,750 mortality cases annually in the USA solely. The aggressive nature and late identification of pancreatic cance...
-
Article
Open AccessCPAP enhances and maintains chronic inflammation in hepatocytes to promote hepatocarcinogenesis
Chronic and persistent inflammation is a well-known carcinogenesis promoter. Hepatocellular carcinoma (HCC) is one of the most common inflammation-associated cancers; most HCCs arise in the setting of chronic ...
