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Article
Open AccessAssociation between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer
Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies suggest that ED can impair antitumor immune responses, but fe...
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Article
Effect of Cd(II) adsorption onto rice roots on its uptake by different indica and japonica rice varieties and toxicity effect of Cd(II) under acidic conditions
The rapid increase in soil acidity coupled with the deleterious effects of cadmium (Cd) toxicity had led to a decline in worldwide agricultural production. Rice absorbs and accumulates Cd(II) from polluted pad...
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Article
Aberrant Enhanced NLRP3 Inflammasomes and Cell Pyroptosis in the Brains of Prion-Infected Rodent Models Are Largely Associated with the Proliferative Astrocytes
Neuroinflammation is a common pathological feature in a number of neurodegenerative diseases, which is mediated primarily by the activated glial cells. Nucleotide-binding oligomerization domain-like receptor p...
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Article
A review of machine learning-based methods for predicting drug–target interactions
The prediction of drug–target interactions (DTI) is a crucial preliminary stage in drug discovery and development, given the substantial risk of failure and the prolonged validation period associated with in v...
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Article
Open AccessOral arsenic plus imatinib versus imatinib solely for newly diagnosed chronic myeloid leukemia: a randomized phase 3 trial with 5-year outcomes
The synergistic effects of combining arsenic compounds with imatinib against chronic myeloid leukemia (CML) have been established using in vitro data. We conducted a clinical trial to compare the efficacy of t...
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Article
A Transformer-Assisted Cascade Learning Network for Choroidal Vessel Segmentation
As a highly vascular eye part, the choroid is crucial in various eye disease diagnoses. However, limited research has focused on the inner structure of the choroid due to the challenges in obtaining sufficient...
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Article
Open AccessDipterocarpoidae genomics reveal their demography and adaptations to Asian rainforests
Dipterocarpoideae species form the emergent layer of Asian rainforests. They are the indicator species for Asian rainforest distribution, but they are severely threatened. Here, to understand their adaptation ...
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Article
Open AccessDiffusion-induced lithium isotopic heterogeneity in olivines from peridotites of an oceanized mantle lithosphere at the Yunzhug ophiolite (central Tibet)
This paper reports lithium concentrations and isotopic compositions of olivines in the oceanized subcontinental lithospheric mantle (SCLM) peridotites of the Tibetan Yunzhug ophiolite. The results show systema...
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Article
Recent advances in vacancy engineering for reliable lithium-sulfur batteries
The high-energy-density and low-cost features endow lithium-sulfur batteries with broad application prospects. However, many drawbacks, especially the detrimental shuttle effect, have hindered the further deve...
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Article
Open AccessRetraction Note: Exosomal lncRNA HNF1A-AS1 affects cisplatin resistance in cervical cancer cells through regulating microRNA-34b/TUFT1 axis
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Article
Quantitative characterization of water absorption pore structure evolution in sandstone based on nitrogen adsorption and mercury intrusion
To investigate the mechanism of water’s effect on the pore structure of rocks, this study relies on the sandstone formation in Wanfu Coal Mine, Shandong, China. Scanning electron microscopy (SEM), nitrogen ads...
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Chapter and Conference Paper
An Experimental Study on the Displacement Characteristics of Discontinuous Depletion Process in Foamy Oil Reservoirs
Depletion process or the so-called cold production from some heavy oil reservoirs in Venezuela and Canada presents foamy oil behavior. The formation and displacement mechanism of foamy oil have been extensivel...
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Chapter and Conference Paper
Impact of Surfactant Concentration on Chemical-Assisted Methane Flooding in Foamy Oil Reservoirs
The primary recovery factor of extra-heavy oils with foamy oil flow characteristic is only 8–12%. In previous studies, an approach of chemical-assisted methane flooding to enhance recovery in foamy oil reservo...
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Article
Open AccessProteomic characterization of epithelial ovarian cancer delineates molecular signatures and therapeutic targets in distinct histological subtypes
Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear....
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Article
Open AccessTargeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
G-protein coupled receptors (GPCRs) are recognized as attractive targets for drug therapy. However, it remains poorly understood how GPCRs, except for a few chemokine receptors, regulate the progression of liv...
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Article
Accumulation of Prion Triggers the Enhanced Glycolysis via Activation of AMKP Pathway in Prion-Infected Rodent and Cell Models
Mitochondrial dysfunction is one of the hallmarks in the pathophysiology of prion disease and other neurodegenerative diseases. Various metabolic dysfunctions are identified and considered to contribute to the...
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Article
Bioaccumulation and translocation of Hg and Cr by tobacco in Sichuan Province, China: understanding the influence of soil pH
The present study investigated the bioaccumulation and translocation of mercury (Hg) and chromium (Cr) in Yunyan 87 flue-cured tobacco (Nicotiana tabacum) and assessed the influence of soil pH on the metal uptake...
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Article
Abnormal Changes of IL3/IL3R and Its Downstream Signaling Pathways in the Prion-Infected Cell Line and in the Brains of Scrapie-Infected Rodents
Interleukin 3 (IL-3) plays an important role in hematopoiesis and immune regulation, brain IL-3/IL-3R signaling has been shown to involve in the physiological and pathological processes of a variety of neurode...
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Article
Open AccessSoluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis
T lymphopenia, occurring in the early phase of sepsis in response to systemic inflammation, is commonly associated with morbidity and mortality of septic infections. We have previously shown that a sufficient ...
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Article
Open AccessPharmacokinetics and Bioequivalence of Abiraterone Acetate Tablets in Healthy Chinese Volunteers: An Open, Randomized, Single-Dose, Three-Period, Three-Sequence Crossover Study
Abiraterone acetate tablet is an inhibitor of androgen synthesis, primarily for the treatment of metastatic castration-resistant prostate cancer (mCRPC). This study evaluated the bioequivalence and pharmacokin...
