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Article
Open AccessInvestigation on the contaminate of hand washing activities on the surface of environmental objects in intensive care unit
To detect the contaminate of faucets in hospitals and the splash during hand washing, and to explore the reasonable layout of hand washing pools. Two faucets with roughly the same spatial layout in the ICU of ...
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Article
The ALMaQUEST Survey XV: The dependence of the molecular-to-atomic gas ratios on resolved optical diagnostics
The atomic-to-molecular gas conversion is a critical step in the baryon cycle of galaxies, which sets the initial conditions for subsequent star formation and influences the multi-phase interstellar medium. We...
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Article
Open AccessSafety, immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly: a prospective longitudinal study
The safety and efficacy of COVID-19 vaccines in the elderly, a high-risk group for severe COVID-19 infection, have not been fully understood. To clarify these issues, this prospective study followed up 157 eld...
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Article
Open AccessTumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling
Whether stem-cell-like cancer cells avert ferroptosis to mediate therapy resistance remains unclear. In this study, using a soft fibrin gel culture system, we found that tumor-repopulating cells (TRCs) with st...
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Article
Open AccessDownregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its role in hepatocellular carcinoma (HCC) is unknown.
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Article
The Angiotensin II Receptor Neprilysin Inhibitor LCZ696 Inhibits the NLRP3 Inflammasome By Reducing Mitochondrial Dysfunction in Macrophages and Alleviates Dextran Sulfate Sodium-induced Colitis in a Mouse Model
The intracellular sensor protein complex known as the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome plays a crucial role in regulating inflammatory diseases by overseeing the production ...
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Article
Open AccessComplement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity
Repeated neonatal sevoflurane exposures led to neurocognitive disorders in young mice. We aimed to assess the role of microglia and complement C1q in sevoflurane-induced neurotoxicity and explore the underlyin...
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Article
Organocatalytic aromatization-promoted umpolung reaction of imines
The umpolung functionalization of imines bears vast synthetic potential, but polarity inversion is less efficient compared with the carbonyl counterparts. Strong nucleophiles are often required to react with t...
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Article
Interactions between overweight/obesity and alcohol dependence impact human brain white matter microstructure: evidence from DTI
There is inconsistent evidence for an association of obesity with white matter microstructural alterations. Such inconsistent findings may be related to the cumulative effects of obesity and alcohol dependence...
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Article
Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids
A strong correlation between gut microbes and host health has been observed in numerous gut metagenomic cohort studies. However, the underlying mechanisms governing host–microbe interactions in the gut remain ...
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Article
Open AccessThe transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony
Sexual development in Toxoplasma gondii is a multistep process that culminates in the production of oocysts, constituting approximately 50% of human infections. However, the molecular mechanisms governing sexual ...
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Article
Open AccessSystemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia
The C-reactive protein (CRP)-triglyceride-glucose (TyG) index (CTI), which is a measure representing the level of inflammation and insulin resistance (IR), is related to poor cancer prognosis; however, the CTI...
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Article
Open AccessMicroglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis
Demyelination and failure of remyelination in the central nervous system (CNS) characterize a number of neurological disorders. Spontaneous remyelination in demyelinating diseases is limited, as oligodendrocyt...
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Chapter and Conference Paper
Recognition of the Types of Buried Hill Gas Reservoirs in Yangshuiwu and Its Significance
Yangshuiwu buried-hill gas reservoir is a Paleozoic carbonate gas reservoir recently discovered in Huabei Oilfield. However, due to the unclear understanding of the gas reservoir, some Wells failed to select t...
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Chapter and Conference Paper
Research and Application of Anisotropic Prestack Inversion Technology Based on OVT Domain Dimension Reduction in Fracture Prediction-Taking Shahezi Formation of Dsh20 Well Area in Anda Area of Northern Songliao Basin as an Example
The tight sandy conglomerate of the Shahezi Formation in the northern Songliao Basin has the characteristics of deep burial, complex structure, diverse lithological assemblages, and rapid changes in sedimentar...
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Article
Open AccessAdvances in nuclear detection and readout techniques
“A Craftsman Must Sharpen His Tools to Do His Job,” said Confucius. Nuclear detection and readout techniques are the foundation of particle physics, nuclear physics, and particle astrophysics to reveal the nat...
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Article
Open AccessComparative and phylogenetic analysis of Chiloschista (Orchidaceae) species and DNA barcoding investigation based on plastid genomes
Chiloschista (Orchidaceae, Aeridinae) is an epiphytic leafless orchid that is mainly distributed in tropical or subtropical forest canopies. This rare and threatened orchid lacks molecular resources for phylogene...
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Article
Open AccessC–C chemokine receptor 5 is essential for conventional NK cell trafficking and liver injury in a murine hepatitis virus-induced fulminant hepatic failure model
Previous studies have demonstrated that natural killer (NK) cells migrated into the liver from peripheral organs and exerted cytotoxic effects on hepatocytes in virus-induced liver failure.
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Article
Open AccessProteomic characterization of epithelial ovarian cancer delineates molecular signatures and therapeutic targets in distinct histological subtypes
Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear....
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Article
Open AccessDlMYB113 mutation affects anthocyanin accumulation in red pericarp longan (Dimocarpus longan Lour.)
Fruit color influences fruit quality and commodity value. Most longan (Dimocarpus longan Lour.) varieties have a yellowish-brown or grayish-yellow pericarp, and the discovery of red pericarp (RP) longan expanded ...
