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  1. Article

    Open Access

    Radiomic signatures reveal multiscale intratumor heterogeneity associated with tissue tolerance and survival in re-irradiated nasopharyngeal carcinoma: a multicenter study

    Post-radiation nasopharyngeal necrosis (PRNN) is a severe adverse event following re-radiotherapy for patients with locally recurrent nasopharyngeal carcinoma (LRNPC) and associated with decreased survival. Bi...

    Ting Liu, Di Dong, Xun Zhao, **ao-Min Ou, Jun-Lin Yi, Jian Guan, Ye Zhang in BMC Medicine (2023)

  2. Article

    Open Access

    Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

    The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial proportion of Chinese population, and understanding the factors underlying the severity of the dis...

    Lin Wang, Jia-Bao Cao, Bin-Bin **a, Yue-Juan Li in Signal Transduction and Targeted Therapy (2023)

  3. Article

    Open Access

    S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway

    Cell senescence deters the activation of various oncogenes. Induction of senescence is, therefore, a potentially effective strategy to interfere with vital processes in tumor cells. Sphingosine-1-phosphate rec...

    Yi-** Tao, Heng-Yan Zhu, Qian-Yuan Shi, Cai-**a Wang, Yu-**n Hua, Han-Yin Hu in Oncogene (2023)

  4. Article

    Open Access

    Divergent projections of the prelimbic cortex mediate autism- and anxiety-like behaviors

    The comorbidity of autism spectrum disorder and anxiety is common, but the underlying circuitry is poorly understood. Here, Tmem74-/- mice showed autism- and anxiety-like behaviors along with increased excitabili...

    Yi-Fan Luo, Lu Lu, Heng-Yi Song, Han Xu, Zhi-Wei Zheng, Zhou-Yue Wu in Molecular Psychiatry (2023)

  5. Article

    Open Access

    Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial

    EMERGING-CTONG 1103 showed improved progression-free survival (PFS) with neoadjuvant erlotinib vs. chemotherapy for patients harbouring EGFR sensibility mutations and R0 resected stage IIIA-N2 non-small cell l...

    Wen-Zhao Zhong, Hong-Hong Yan, Ke-Neng Chen in Signal Transduction and Targeted Therapy (2023)

  6. No Access

    Article

    Infusion of haploidentical HSCs combined with allogenic MSCs for the treatment of ALL patients

    Although haploidentical stem cell transplantation (haplo-HSCT) offers almost all acute lymphoblastic leukaemia (ALL) patients an opportunity for immediate transplantation, it exhibits a higher incidence of gra...

    Li Ding, Dong-Mei Han, Hong-Min Yan, Jie-**n Zhou in Bone Marrow Transplantation (2022)

  7. Article

    Hypertension Exacerbates Severity and Outcomes of COVID-19 in Elderly Patients: A Retrospective Observational Study

    To evaluate the impact of hypertension on the clinical outcome of COVID-19 patients aged 60 years old and older.

    Li-song Dai, Meng-pei Zhu, Yu-min Li, Hong-mei Zhou in Current Medical Science (2022)

  8. Article

    Open Access

    Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

    Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti-CD147 antibody could suppress the in vitro SAR...

    Huijie Bian, Zhao-Hui Zheng, Ding Wei in Signal Transduction and Targeted Therapy (2021)

  9. No Access

    Article

    Effect of Shuanghu Qinggan Granule (双虎清肝颗粒) and Yigan Yiqi Jieyu Granule (乙肝益气解郁颗粒) plus lamivudine on chronic hepatitis B patients: A randomized double-blind placebo-controlled trial

    To observe the clinical efficacy and safety of Shuanghu Qinggan Granule (双虎清肝颗 粒, SQG) plus Yigan Yiqi Jieyu Granule (乙肝益气解郁颗粒, YYJG) combined with lamivudine (LAM) on chronic hepatitis B (CHB) patients.

    Yong-an Ye 叶永安, De-lu Tian 田德录, Jian Jiang 蒋 健 in Chinese Journal of Integrative Medicine (2016)

  10. No Access

    Article

    Right hemicolectomy and multivisceral resection of right colon cancer: A report of 21 cases

    The long- and short-term outcomes in 21 patients with right colon cancer after right hemicolectomy and multivisceral resection surgery were investigated. Short-term therapeutic effects and long-term survival r...

    Yu-zhou Zhao 赵玉洲, Guang-sen Han **广森 in Journal of Huazhong University of Science … (2015)

  11. Article

    Open Access

    Glycemic control among patients in China with type 2 diabetes mellitus receiving oral drugs or injectables

    The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly among Chinese adults, and limited data are available on T2DM management and the status of glycemic control in China. We assessed the effi...

    Li-Nong Ji, Ju-Ming Lu, **ao-Hui Guo, Wen-Ying Yang, Jian-** Weng in BMC Public Health (2013)

  12. No Access

    Article

    Study on effect of mediation principle in retarding progress of chronic renal failure

    Objective: To evaluate the effect of mediation principle in retarding the progress of chronic renal failure.Methods: One hundred patients with chronic renal failure (CRF)were treated main...

    Yong-Li Zhan, **g-Yuan Zhou, Bao-Min Huo in Chinese Journal of Integrated Traditional … (1997)