20 Result(s)

Article

Safety and efficacy of CD22 and CD19 CAR-T bridging auto-HSCT as consolidation therapy for AYA and adult B-ALL

Yan Qiu, Chao-Ling Wan, Ming-Zhu Xu, Hai-**a Zhou, Mei-**g Liu… in Blood Cancer Journal (2023)

Article

A Cohort Study on Deficiency of ADA2 from China

Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in adenosine deaminase 2 (ADA2), has not been systemically investigat...

Guo-min Li, Xu Han, Ye Wu, Wei Wang, Hong-xia Tang… in Journal of Clinical Immunology (2023)

Article

Body mass index and incidence of lung cancer in the HUNT study: using observational and Mendelian randomization approaches

Traditional observational studies have shown an inverse association between body mass index (BMI) and lung cancer risk. Mendelian randomization (MR) analysis using genetic variants as instruments for BMI may c...

Lin Jiang, Yi-Qian Sun, Ben Michael Brumpton, Arnulf Langhammer, Yue Chen… in BMC Cancer (2022)

Article

Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring

Primary lung cancer is one of the most common malignant tumors in China. Approximately 60% of lung cancer patients have distant metastasis at the initial diagnosis, so it is necessary to find new tumor markers...

Wen Li, Ji-Bin Liu, Li-Kun Hou, Fei Yu, Jie Zhang, Wei Wu… in Molecular Cancer (2022)

Article

Regulation of melanoma malignancy by the RP11-705C15.3/miR-145-5p/NRAS/MAPK signaling axis

Melanoma is a common lethal skin cancer. Dissecting molecular mechanisms driving the malignancy of melanoma may uncover potential therapeutic targets. We previously identified miR-145-5p as an important tumor-...

**ang-jun Chen, Sha Liu, Dong-mei Han, De-zhi Han, Wei-**g Sun… in Cancer Gene Therapy (2021)

Article

Unraveling tumour microenvironment heterogeneity in nasopharyngeal carcinoma identifies biologically distinct immune subtypes predicting prognosis and immunotherapy responses

Currently, there is no strong evidence of the well-established biomarkers for immune checkpoint inhibitors (ICIs) in nasopharyngeal carcinoma (NPC). Here, we aimed to reveal the heterogeneity of tumour microen...

Yu-Pei Chen, Jia-Wei Lv, Yan-** Mao, **ao-Min Li, Jun-Yan Li… in Molecular Cancer (2021)

Article

Correction to: Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)

In the original publication of this manuscript [1], Fig. 6 contains a repeated image in error (the left image of ‘Migration’ and the left image of ‘Invasion’).

Yi-fang Lu, Jia-rui Yu, Zhao Yang… in Journal of Experimental & Clinical Cancer … (2020)

Article

FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic fatty liver disease

Innate immune dysfunction contributes to the development and progression of nonalcoholic fatty liver disease (NAFLD), however, its pathogenesis is still incompletely understood. Identifying the key innate immu...

Cheng Zhang, Feng Chen, Li Feng, Qun Shan, Gui-Hong Zheng… in Molecular Medicine (2019)

Article

Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)

Esophageal cancer is a high incident cancer worldwide with poor survival and limited therapeutic options. Alterations of microRNAs are common in cancers, and many of these micro RNAs are potential therapeutic ...

Yi-fang Lu, Jia-rui Yu, Zhao Yang… in Journal of Experimental & Clinical Cancer … (2018)

Article

miR-4317 suppresses non-small cell lung cancer (NSCLC) by targeting fibroblast growth factor 9 (FGF9) and cyclin D2 (CCND2)

Non-small cell lung cancer (NSCLC) is a leading cause of death worldwide. MicroRNAs (miRNAs) have been indicated as crucial actors in cancer biology. Accumulating evidence suggests that miRNAs can be used as d...

** He, Si-yuan Chen, Zhao Yang, Jie Zhang… in Journal of Experimental & Clinical Cancer … (2018)

Article

Along with its favorable prognostic role, CLCA2 inhibits growth and metastasis of nasopharyngeal carcinoma cells via inhibition of FAK/ERK signaling

CLCA2 was reported as a tumor suppressor and disregulated in breast cancer. However, its function in tumor growth and metastasis in NPC has rarely been reported. In this study, we investigated the functional a...

Yuan-Yuan Qiang, Chang-Zhi Li, Rui Sun… in Journal of Experimental & Clinical Cancer … (2018)

Article

Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretion

The communication between carcinoma associated fibroblasts (CAFs) and cancer cells facilitate tumor metastasis. In this study, we further underlying the epigenetic mechanisms of CAFs feed the cancer cells and ...

Yu Ren, Huan-huan Jia, Yi-qi Xu, Xuan Zhou, **ao-hui Zhao, Yun-fei Wang… in Molecular Cancer (2018)

Article

Abstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC)

Nantanit Sutthiruk, Mari Botti… in Antimicrobial Resistance & Infection Contr… (2017)

Article

Bufalin derivative BF211 inhibits proteasome activity in human lung cancer cells in vitro by inhibiting β1 subunit expression and disrupting proteasome assembly

Bufalin is one of the active components in the traditional Chinese medicine ChanSu that is used to treat arrhythmia, inflammation and cancer. BF211 is a bufalin derivative with stronger cytotoxic activity in c...

Peng Sun, Li-xing Feng, Dong-mei Zhang, Miao Liu, Wang Liu… in Acta Pharmacologica Sinica (2016)

Article

Prednisone treatment inhibits the differentiation of B lymphocytes into plasma cells in MRL/MpSlac-lpr mice

A number of evidence shows that the differentiation of B lymphocytes into plasma cells plays an important role in lupus pathogenesis. In this study we investigated how prednisone, a classical therapeutic drug ...

Shang-xue Yan, **ao-mei Deng, Qing-tong Wang, **ao-**g Sun… in Acta Pharmacologica Sinica (2015)

Article

Electroacupuncture alleviates retrieval of pain memory and its effect on phosphorylation of cAMP response element-binding protein in anterior cingulate cortex in rats

Recent evidence suggests that persistent pain and recurrent pain are due to the pain memory which is related to the phosphorylation of cAMP response element-binding protein (p-CREB) in anterior cingulate corte...

**g Sun, **ao-mei Shao, Fang Fang, Zui Shen… in Behavioral and Brain Functions (2015)

Article

Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia

Pediatric acute myeloid leukemia (AML) comprises up to 20% of all childhood leukemia. Recent research shows that aberrant DNA methylation patterning may play a role in leukemogenesis. The epigenetic silencing ...

Yan-Fang Tao, Li-**ao Xu, Jun Lu… in Journal of Experimental & Clinical Cancer … (2015)

Article

Corrigendum: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54

Nat. Genet. 42, 759–763 (2010); published online 22 August 2010; corrected after print 27 August 2014 In contrast to the version of this article initially published, the authors now find no evidence to support...

Li-Dong Wang, Fu-You Zhou, Xue-Min Li, Liang-Dan Sun, **n Song, Yan **… in Nature Genetics (2014)

Article

Analysis of endophytic fungi in roots of Santalum album Linn. and its host plant Kuhnia rosmarinifolia Vent.

Santalum album Linn. is an evergreen and hemi-parasitic tree, the heartwood-sandalwood of which was used during a long history in traditional Chinese medicine. Kuhnia rosmarinifolia Vent. is a go...

Si-sheng Sun, **ao-mei Chen, Shun-xing Guo in Journal of Zhejiang University SCIENCE B (2014)

Article

Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development

Neuron-derived neurotrophic factor (NDNF) is evolutionarily well conserved, being present in invertebrate animals such as the nematode, Caenorhabditis elegans, as well as in the fruit fly, Drosophila melanogaster

**u-Li Kuang, **ao-Mei Zhao, Hai-Fang Xu, Yuan-Yuan Shi, **-Bo Deng… in BMC Neuroscience (2010)