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  1. No Access

    Article

    Overexpression of the PLK4 Gene as a Novel Strategy for the Treatment of Autosomal Recessive Microcephaly by Improving Centrosomal Dysfunction

    Autosomal recessive microcephaly and chorioretinopathy (MCCRP) is a neurodevelopmental disorder characterized by delayed psychomotor development, growth retardation with dwarfism, and ocular abnormalities, and...

    Ya-Song Xu, Zhi-Ying Su, Li Sun, **ao-Mei Yang… in Journal of Molecular Neuroscience (2021)

  2. No Access

    Article

    Proteomic Analyses for the Global S-Nitrosylated Proteins in the Brain Tissues of Different Human Prion Diseases

    Human prion diseases are fatal neurodegenerative disorders characterized by neuronal damage in brain. Protein S-nitrosylation, the covalent adduction of a NO to cysteine, plays a role in human brain biology, and ...

    Li-Na Chen, Qi Shi, Bao-Yun Zhang, **ao-Mei Zhang, **g Wang… in Molecular Neurobiology (2016)

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    Article

    The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells

    Chemotherapy- or radiotherapy-induced DNA damage activates the Chk1-dependent DNA damage response (DDR) and cell cycle checkpoints to facilitate cell survival. Numerous attempts have been made to identify spec...

    Feng-Ze Wang, Hong-rong Fei, Ying-Jie Cui, Ying-Kun Sun, Zhao-Mei Li… in Apoptosis (2014)

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    Article

    Antiangiogenic therapy promoted metastasis of hepatocellular carcinoma by suppressing host-derived interleukin-12b in mouse models

    Antiangiogenic therapy, specially sorafenib, has become the standard of care for patients with advanced hepatocellular carcinoma (HCC), however, the improvement in survival time is not satisfactory. Previous s...

    **ao-Dong Zhu, Hui-Chuan Sun, Hua-**ang Xu, Ling-Qun Kong, Zong-Tao Chai… in Angiogenesis (2013)