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Article
Open AccessThe causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study
Most of hepatocellular carcinoma (HCC) arises on the background of chronic inflammation. The presence of infiltrating inflammatory cells is associated with tumour initiation, progression and clinical response ...
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Article
Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter
Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter.
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Article
A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy
Zhang and colleagues have developed a new targeted delivery system for RNA interference–based bone anabolic therapy. Using dioleoyl trimethylammonium propane (DOTAP)-based cationic liposomes attached to six re...
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Article
The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension
Calcineurin inhibitors, such as tacrolimus, are widely used immunosuppressive agents, but they can cause hypertension. In studies of tacrolimus-treated mice, the authors show that hypertension is due to activa...