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Article
ZnO/ZnS heterostructure in N-doped porous carbon for anchoring–diffusion–conversion of polysulfides for high-performance lithium–sulfur batteries
The shuttle effect of polysulfides is one of the key factors hindering the commercialization of lithium–sulfur batteries (LSBs). Owing to their high conductivity and advantageous structure, heterostructures ca...
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Article
Isolation and characterization of three DREB-like genes encoding dehydration-responsive element binding proteins in chicory (Cichorium intybus)
Three novel DREB (Dehydration-Responsive Element Binding protein) genes, designated as CiDREB2A, CiDREB5A and CiDREB6A, were individually isolated from chicory (Cichorium intybus L). Based on phylogenetic tree an...
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Article
CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells
Dynamic imaging of genomic loci is key for understanding gene regulation, but methods for imaging genomes, in particular non-repetitive DNAs, are limited. We developed CRISPRdelight, a DNA-labeling system base...
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Article
Open AccessSensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice
Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerb...
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Article
Correction: Comparing Sonazoid contrast-enhanced ultrasound to contrast-enhanced CT and MRI for differentially diagnosing renal lesions: a prospective multicenter study
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Article
Metabolomics efficiently discriminates monozygotic twins in peripheral blood
Monozygotic (MZ) twins cannot be distinguished using conventional forensic STR ty** because they present identical STR genoty**s. However, MZ twins do not always live in the same environment and often have...
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Article
Structural engineering of Sb-based electrode materials to enhance advanced sodium-ion batteries
Antimony (Sb) is recognized as a potential electrode material for sodium-ion batteries (SIBs) due to its huge reserves, affordability, and high theoretical capacity (660 mAh·g−1). However, Sb-based materials expe...
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Article
Open AccessA multicenter prospective study on the management of hepatoblastoma in children: a report from the Chinese Children’s Cancer Group
This study aimed to identify survival risk factors in Chinese children with hepatoblastoma (HB) and assess the effectiveness of the new treatment protocol proposed by the Chinese Children’s Cancer Group (CCCG)...
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Article
Open AccessA novel protein FNDC3B-267aa encoded by circ0003692 inhibits gastric cancer metastasis via promoting proteasomal degradation of c-Myc
Gastric cancer (GC) ranks fifth in global cancer incidence and third in mortality rate among all cancer types. Circular RNAs (circRNAs) have been extensively demonstrated to regulate multiple malignant biologi...
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Article
Comparing Sonazoid contrast-enhanced ultrasound to contrast-enhanced CT and MRI for differentially diagnosing renal lesions: a prospective multicenter study
To evaluate the diagnostic performance of contrast-enhanced (CE) ultrasound using Sonazoid (SNZ–CEUS) by comparing with contrast-enhanced computed tomography (CE–CT) and contrast-enhanced magnetic resonance im...
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Article
Open AccessPeriodontal disease increases the severity of chronic obstructive pulmonary disease: a Mendelian randomization study
Recent research suggests that periodontitis can increase the risk of chronic obstructive pulmonary disease (COPD). In this study, we performed two-sample Mendelian randomization (MR) and investigated the causa...
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Article
Four Labdane Diterpenoids from Leonurus japonicus
A new labdane diterpenoid, leojaponotin (1), and three known labdane diterpenoids (2–4), were isolated from Leonurus japonicus. Their structures were elucidated by spectroscopic analysis including NMR and MS.
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Article
RNA m6A methylation and regulatory proteins in pulmonary arterial hypertension
m6A (N6‑methyladenosine) is the most common and abundant apparent modification in mRNA of eukaryotes. The modification of m6A is regulated dynamically and reversibly by methyltransferase (writer), demethylase ...
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Article
Analysis of related factors influencing postoperative recurrence of adenomyosis treated with HIFU
To analyze the efficacy of high-intensity focused ultrasound (HIFU) for adenomyosis and postoperative recurrence and its influencing factors.
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Article
Open AccessMouse serum albumin induces neuronal apoptosis and tauopathies
The elderly frequently present impaired blood–brain barrier which is closely associated with various neurodegenerative diseases. However, how the albumin, the most abundant protein in the plasma, leaking throu...
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Article
Open AccessDownregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its role in hepatocellular carcinoma (HCC) is unknown.
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Article
Open AccessThrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease
The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. W...
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Article
Toll-like receptor 3 signaling drives enteric glial cells against dextran sulfate sodium-induced colitis in mice
The activation of toll-like receptor 3 (TLR3) has been reported to attenuate astrocytes injury in central nervous system, but its effect on enteric glial cells (EGCs) remains unknown. Here, we confirmed that t...
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Article
Open AccessPropofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4
Propofol is a widely used anesthetic and sedative, which has been reported to exert an anti-inflammatory effect. TLR4 plays a critical role in coordinating the immuno-inflammatory response during sepsis. Wheth...
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Article
Melatonin Enhanced Microglia M2 Polarization in Rat Model of Neuro-inflammation Via Regulating ER Stress/PPARδ/SIRT1 Signaling Axis
Neuro-inflammation involves distinct alterations of microglial phenotypes, containing nocuous pro-inflammatory M1-phenotype and neuroprotective anti-inflammatory M-phenotype. Currently, there is no effective t...
