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Article
Etiological Mechanisms and Genetic/Biological Modulation Related to PTH1R in Primary Failure of Tooth Eruption
Primary failure of eruption (PFE) is a rare disorder that is characterized by the inability of a molar tooth/teeth to erupt to the occlusal plane or to normally react to orthodontic force. This condition is re...
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Article
Rab11b promotes M1-like macrophage polarization by restraining autophagic degradation of NLRP3 in alcohol-associated liver disease
Macrophage polarization is vital to mounting a host defense or repairing tissue in various liver diseases. Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is related to th...
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Article
Surface diffraction beamline at the SSRF
BL02U2 of the Shanghai Synchrotron Radiation Facility is a surface diffraction beamline with a photon flux of 5.5 × 1012 photons/s at 10 keV and a beam size of 160 µm × 80 µm at the sample site. It is dedicated t...
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Article
Visualization for physics analysis improvement and applications in BESIII
Modern particle physics experiments usually rely on highly complex and large-scale spectrometer devices. In high energy physics experiments, visualization helps detector design, data quality monitoring, offlin...
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Article
Open AccessKnowledge of Alzheimer’s disease and associated factors among adults in Zhuhai, China: a cross-sectional analysis
This study aimed to assess the public knowledge regarding Alzheimer’s Disease (AD) in Zhuhai, China, focusing on identifying knowledge gaps and the influence of demographic and health factors.
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Article
A novel oligo(N,O-donor) fluorescent probe possessed the CHEF effect for identification of aluminum ions in the environment
An oligo(N,O-donor) fluorescent probe SAS with high selectivity for Al3+ in DMF: H2O (V/V, 9:1) Tris–HCl solution was designed and synthesized. That is to say, the increase of Al3+ activates specific fluorescence...
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Article
A new tau dephosphorylation-targeting chimera for the treatment of tauopathies
Abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies, including Alzheimer’s disease (AD). We have recently conceptualize...
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Article
D-band center coordination modulated enzyme-like activity in Fe-Cu dual-metal single-atom nanozymes
After explorations in a diversity of single-atom nanozymes (SAzymes), develo** dual-centered SAzymes becomes a promising approach for superior catalytic performance. But confusing mechanisms including atomic...
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Article
Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury
Acute kidney injury (AKI) is often accompanied by uremic encephalopathy resulting from accumulation of uremic toxins in brain possibly due to impaired blood-brain barrier (BBB) function. Anionic uremic toxins ...
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Article
Plasmon coupling-driven enhanced high-order multiphoton excited fluorescent performance of metal-organic frameworks
Accessing high-order multiphoton excited fluorescence (H-MPEF) materials is challenging yet and needs complicated synthesis procedures. In this study, we successfully assembled plasmonic Au nanorods (Au NRs) w...
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Article
Open AccessA pan-KRAS degrader for the treatment of KRAS-mutant cancers
KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer progression and conferring resistance to treatment. While there have bee...
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Article
Open AccessSensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice
Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerb...
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Article
Recent advances in glycerol valorization through electrocatalytic methods
The recent tremendous growth of biodiesel production from vegetable oils or waste fats has led to increased glycerol accumulation as a by-product of this process. This sparked attention towards glycerol use an...
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Article
Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability
The impairment of blood-brain barrier (BBB) integrity is the pathological basis of hemorrhage transformation and vasogenic edema following thrombolysis and endovascular therapy. There is no approved drug in th...
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Article
One-neutron strip** process in the 209Bi(6Li, 5Li)210Bi* reaction reaction
One-neutron strip** process between \(^{6}\) 6 ...
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Article
Bio-inspired barnacle cement coating of biodegradable magnesium alloy for cerebrovascular application
Ischemic stroke is increasing worldwide, and stent intervention has gradually become one of the effective treatments. Owing to its good mechanical properties and biocompatibility, biodegradable Mg-Zn-Y-Nd allo...
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Article
Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
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Article
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Article
Open AccessSolar overall water-splitting by a spin-hybrid all-organic semiconductor
Direct solar-to-hydrogen conversion from pure water using all-organic heterogeneous catalysts remains elusive. The challenges are twofold: (i) full-band low-frequent photons in the solar spectrum cannot be har...
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Article
Open AccessComparative transcriptome analysis reveals genes involved in trichome development and metabolism in tobacco
The glandular trichomes of tobacco (Nicotiana tabacum) can efficiently produce secondary metabolites. They act as natural bioreactors, and their natural products function to protect plants against insect-pests an...
