39 Result(s)
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Article
Is an Aggressive Bisphosphonate-Based Regimen More Appropriate for CNO Mandibular Involvement?
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Article
Open AccessPRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells
Maintaining genomic stability is a prerequisite for proliferating NPCs to ensure genetic fidelity. Though histone arginine methylation has been shown to play important roles in safeguarding genomic stability, ...
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Article
Triterpenoids from the Fruits of Wild Species of Crataegus scabrifolia and Their Lipid-Lowering Activities
To investigate the chemical constituents of fruits of wild species of Crataegus scabrifolia and their lipid-lowering activities. The compounds were isolated and purified by various column chromatography, and thei...
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Article
Open AccessE2F1-initiated transcription of PRSS22 promotes breast cancer metastasis by cleaving ANXA1 and activating FPR2/ERK signaling pathway
Breast cancer (BC) is the most common malignant tumor in women worldwide. Metastasis is the main cause of BC-related death. The specific mechanism underlying BC metastasis remains obscure. Recently, PRSS22 was...
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Article
Transcriptomic Analysis of Morphology Regulatory Mechanisms of Microparticles to Paraisaria dubia in Submerged Fermentation
Liquid submerged fermentation is an effective strategy to achieve large-scale production of active ingredients by macrofungi, and controlling mycelium morphology is a key factor restricting the development of ...
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Article
Expression and characterization of a thermostable lipase from Thermomyces dupontii
Interest in the identification of thermostable lipases for industrial applications is growing. Herein, the novel thermostable lipase TDL2 was identified from the thermophilic fungus Thermomyces dupontii ATCC 1646...
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Article
Matrix compatibility of typical sol–gel solid-phase microextraction coatings in undiluted plasma and whole blood for the analysis of phthalic acid esters
Sol–gel materials have been widely used for solid-phase microextraction (SPME) coatings due to their outstanding performance; in contrast, sol–gel SPME coatings have seldom been used for in vivo sampling. The ...
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Article
Nakamurella leprariae sp. nov., isolated from a lichen sample
A novel actinobacterium, YIM 132084T, was isolated from Lepraria sp. lichen collected from Yunnan province, south-west PR China and identified by a polyphasic taxonomic approach. The strain was Gram-stain-positiv...
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Article
Open AccessGenome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development
Liver development is a highly complex process that is regulated by the orchestrated interplay of epigenetic regulators, transcription factors, and microRNAs (miRNAs). Owing to the lack of global in vivo target...
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Article
Recent progress of oridonin and its derivatives for cancer therapy and drug resistance
Numerous antitumor drugs exhibited excellent anti-proliferation activities, discovered from natural products. Oridonin is isolated from a traditional Chinese medicine Isodon rubescens, and it exhibit various biol...
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Article
Sodium Para-aminosalicylic Acid Reverses Changes of Glutamate Turnover in Manganese-Exposed Rats
Sodium para-aminosalicylic acid (PAS-Na) has been used to treat patients with manganism, a neurological disease caused by manganese (Mn) toxicity, although the exact molecular mechanisms are yet unclear. The p...
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Article
Topology-dependent interference of synthetic gene circuit function by growth feedback
Growth-mediated feedback between synthetic gene circuits and host organisms leads to diverse emerged behaviors, including growth bistability and enhanced ultrasensitivity. However, the range of possible impact...
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Article
Lipopolysaccharide induces the differentiation of hepatic progenitor cells into myofibroblasts constitutes the hepatocarcinogenesis-associated microenvironment
Hepatocellular carcinoma (HCC) generally occurs in the presence of chronic liver injury, often as a sequela of liver fibrosis. Hepatic progenitor cells (HPCs) are known to be capable of forming both hepatocyte...
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Open AccessAuthor Correction: Identification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer
After publication of this article, it came to the attention of the authors that their names had been reordered. Professor. Jia Cao and Prof. **-yi Liu are the co-corresponding authors, and Prof. **-yi Liu sh...
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Open AccessIdentification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer
Although TC2N has proven to be an oncogene in lung cancer, its biological function and molecular mechanisms in other cancer still remains unclear. Here, we investigate in breast cancer that TC2N expression is ...
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Open AccessInhibition of the JNK/MAPK signaling pathway by myogenesis-associated miRNAs is required for skeletal muscle development
Skeletal muscle differentiation is controlled by multiple cell signaling pathways, however, the JNK/MAPK signaling pathway dominating this process has not been fully elucidated. Here, we report that the JNK/MA...
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Article
Mutation screening of Chinese Treacher Collins syndrome patients identified novel TCOF1 mutations
Treacher Collins syndrome (TCS) (OMIM 154500) is a rare congenital craniofacial disorder with an autosomal dominant manner of inheritance in most cases. To date, three pathogenic genes (TCOF1, POLR1D and POLR1C) ...
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Viral IL-10 down-regulates the “MHC-I antigen processing operon” through the NF-κB signaling pathway in nasopharyngeal carcinoma cells
The HLA-I antigen processing machinery (APM) plays a crucial role in the anticancer immune response. The loss of surface expression of HLA-I molecules is particularly important as this enables tumor cells to ...
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The miR-573/apoM/Bcl2A1-dependent signal transduction pathway is essential for hepatocyte apoptosis and hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with an increasing incidence worldwide. Apolipoprotein M (apoM) is a novel apolipoprotein that is mainly expressed in liver and kidney ...
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Article
Bone Marrow Mesenchymal Stem Cell-Derived Microvesicles Protect Rat Pheochromocytoma PC12 Cells from Glutamate-Induced Injury via a PI3K/Akt Dependent Pathway
Studies have suggested that mesenchymal stem cells (MSCs) can protect neuronal cells from excitotoxicity, but the underlying mechanisms are still remaining elusive. In the study, we show that microvesicles rel...
