23 Result(s)

Article

Sodium Para-Aminosalicylic Acid Modulates Autophagy to Lessen Lead-Induced Neurodegeneration in Rat Cortex

Lead (Pb) is a common heavy metal contaminant in the environment, and it may perturb autophagy and cause neurodegeneration. Although sodium para-aminosalicylic (PAS-Na) has been shown to protect the brain from...

Lei-lei Wang, **ao-juan Zhu, Yuan-yuan Fang, Yan Li… in Neurotoxicity Research (2023)

Article

Oxygen Metabolism-induced Stress Response Underlies Heart–brain Interaction Governing Human Consciousness-breaking and Attention

Neuroscientists have emphasized visceral influences on consciousness and attention, but the potential neurophysiological pathways remain under exploration. Here, we found two neurophysiological pathways of hea...

**ao-Juan Xue, Rui Su, Ze-Feng Li, **ao-Ou Bu, Peng Dang… in Neuroscience Bulletin (2022)

Article

Association of Genetic Polymorphisms with Age at Onset in Han Chinese Patients with Bipolar Disorder

Shao-Hua Hu, Yu-Qing Han, Ting-Ting Mou, Man-Li Huang, Jian-Bo Lai… in Neuroscience Bulletin (2019)

Article

Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis

Myelin-associated inhibitors, such as NogoA, myelin-associated glycoprotein (MAG), and oligodendrocyte myelin glycoprotein (OMgp), play a pivotal role in the lack of neuroregeneration in multiple sclerosis, an...

Quan-Cheng Kan, Hui-Jun Zhang, Yuan Zhang, **ng Li, Yu-Ming Xu… in Molecular Neurobiology (2017)

Article

MEF2D Mediates the Neuroprotective Effect of Methylene Blue Against Glutamate-Induced Oxidative Damage in HT22 Hippocampal Cells

Methylene blue (MB) can ameliorate behavioral, neurochemical, and neuropathological impairments in animal models of acute and chronic neurodegenerative disorders, but the underlying mechanism remains unclear. ...

Zi-wei Chen, Anmin Liu, Qingyu Liu, **gkao Chen, Wen-ming Li… in Molecular Neurobiology (2017)

Article

Olfactory Dysfunction in Parkinson’s Disease Patients with the LRRK2 G2385R Variant

Olfactory dysfunction has been reported in Parkinson’s disease (PD) patients carrying the LRRK2 G2019S variant in Caucasians but rarely in those with the LRRK2 G2385R variant. In this study, we performed genotypi...

Ming Cao, Zhu-Qin Gu, Yuan Li, Hui Zhang, **ao-Juan Dan… in Neuroscience Bulletin (2016)

Article

Species-specific differences in the role of L-type Ca²⁺ channels in the regulation of coronary arterial smooth muscle contraction

The L-type calcium channel (LCC) plays a regulatory role in various physical and pathological processes. In the vasculature, LCCs mediate agonist-induced vascular smooth muscle contraction. However, whether LC...

Hui Yang, Su-Juan Kuang, Fang Rao… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2016)

Article

Erythropoietin Attenuates the Apoptosis of Adult Neurons After Brachial Plexus Root Avulsion by Downregulating JNK Phosphorylation and c-Jun Expression and Inhibiting c-PARP Cleavage

In the present study, the effects of erythropoietin (EPO) on preventing adult neurons from apoptosis (introduced by brachial plexus avulsion) were examined, and the mechanism was analyzed. Fifty injury rat mod...

Kai Li, Rang-Juan Cao, **ao-Juan Zhu, **ng-Yu Liu… in Journal of Molecular Neuroscience (2015)

Article

Bone Marrow Mesenchymal Stem Cell-Derived Microvesicles Protect Rat Pheochromocytoma PC12 Cells from Glutamate-Induced Injury via a PI3K/Akt Dependent Pathway

Studies have suggested that mesenchymal stem cells (MSCs) can protect neuronal cells from excitotoxicity, but the underlying mechanisms are still remaining elusive. In the study, we show that microvesicles rel...

Shan-Shan Lin, Bo Zhu, Zi-Kuan Guo, Guo-Zhi Huang, Zi Wang… in Neurochemical Research (2014)

Article

Oxysophoridine Protects Against Focal Cerebral Ischemic Injury by Inhibiting Oxidative Stress and Apoptosis in Mice

Our previous studies have demonstrated that oxysophoridine (OSR) has protective effects on cerebral neurons damage in vitro induced by oxygen and glucose deprivation. In this study, we further investigated whe...

Teng-Fei Wang, Zhen Lei, Yu-**ang Li, Yong-Sheng Wang, Jie Wang… in Neurochemical Research (2013)

Article

Protective Effects of Hesperidin Against Amyloid-β (Aβ) Induced Neurotoxicity Through the Voltage Dependent Anion Channel 1 (VDAC1)-Mediated Mitochondrial Apoptotic Pathway in PC12 Cells

Amyloid-β (Aβ) is known to exert cytotoxic effects by inducing mitochondrial dysfunction. Additionally, the mitochondrial voltage-dependent anion channel 1 (VDAC1), which is involved in the release of apoptoti...

Dong-Mei Wang, San-Qiang Li, **ao-Ying Zhu, Yong Wang, Wen-Lan Wu… in Neurochemical Research (2013)

Article

Aggravated inflammation and increased expression of cysteinyl leukotriene receptors in the brain after focal cerebral ischemia in AQP4-deficient mice

Aquaporin-4 (AQP4), the main water channel protein in the brain, plays a critical role in water homeostasis and brain edema. Here, we investigated its role in the inflammatory responses after focal cerebral is...

Wen-Zhen Shi, Chun-Zhen Zhao, Bing Zhao, Qiao-Juan Shi… in Neuroscience Bulletin (2012)

Article

Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy

In mouse models, the authors find that NRG1–ErbB4 signaling contributes to epilepsy through regulating the excitability of fast-spiking parvalbumin interneurons. ErbB4 expression was also reduced in human epil...

Ke-**n Li, Ying-Mei Lu, Zheng-Hao Xu, **g Zhang, Jun-Ming Zhu… in Nature Neuroscience (2012)