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Article
Dual-Region Computed Tomography Radiomics-Based Machine Learning Predicts Subcarinal Lymph Node Metastasis in Patients with Non-small Cell Lung Cancer
Noninvasively and accurately predicting subcarinal lymph node metastasis (SLNM) for patients with non-small cell lung cancer (NSCLC) remains challenging. This study was designed to develop and validate a tumor...
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Article
A review on WO3-based composite photocatalysts: synthesis, catalytic mechanism and diversified applications
Photocatalysis as an emerging “green” energy conversion technology has attracted domestic and international attention. This technology uses semiconductor photocatalysts to convert solar energy into directly us...
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Article
Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice
To investigate the potential role of Tongxinluo (TXL) in attenuating myocardial fibrosis after myocardial ischemia-reperfusion injury (MIRI) in mice.
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Article
Open AccessPI3K/AKT/mTOR signaling pathway: an important driver and therapeutic target in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a highly heterogeneous tumor lacking estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. It has higher ag...
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Article
ASO Author Reflections: The Clinical Use of Dual-Region Radiomics-Based Machine Learning in the Identification of Subcarinal Lymph Node Metastasis of Non-small Cell Lung Cancer
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Article
Characterization of Gut Microbiota in Rats and Rhesus Monkeys After Methamphetamine Self-administration
Methamphetamine (MA) is one of the most abused drugs globally, but the mechanism of its addiction remains unclear. Several animal studies have shown that the gut microbiota (GM) influences addictive behaviors,...
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Article
From Perspective of Hippocampal Plasticity: Function of Antidepressant Chinese Medicine **aoyaosan
The hippocampus is one of the most commonly studied brain regions in the context of depression. The volume of the hippocampus is significantly reduced in patients with depression, which severely disrupts hippo...
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Article
Application of optimized random forest regressors in predicting the maximum principal stress of aseismic tunnel lining
Using flexible dam** technology to improve tunnel lining structure is an emerging method to resist earthquake disasters, and several methods have been explored to predict mechanical response of tunnel lining...
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Article
A novel dual-signal output strategy for POCT of CEA based on a smartphone electrochemical aptasensing platform
A smartphone-based electrochemical aptasensing platform was developed for the point-of-care testing (POCT) of carcinoembryonic antigen (CEA) based on the ferrocene (Fc) and PdPt@PCN-224 dual-signal labeled st...
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Article
Unveiling the Re, Cr, and I diffusion in saturated compacted bentonite using machine-learning methods
The safety assessment of high-level radioactive waste repositories requires a high predictive accuracy for radionuclide diffusion and a comprehensive understanding of the diffusion mechanism. In this study, a ...
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Article
Parameter optimization of the observation system for the South Yellow Sea strong shielding layer based on seismic illumination analysis
The seismic data of the Laoshan Uplift in the South Yellow Sea Basin reveal a low signal-to-noise ratio and low reflection signal energy in the deep Mesozoic–Paleozoic strata. The main reason is that the Mesoz...
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Article
Optimized preparation and performances of semi-embedded periodic Ag grid/F-doped SnO2 transparent electrodes and heaters based on laser direct writing
Semi-embedded periodic Ag grids were combined with FTO/glass substrates based on laser direct writing to prepare transparent electrodes (TEs). The laser etching parameters (scanning velocity and energy density...
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Article
The risk factors of early arterial stiffness in type 2 diabetes without diabetic macroangiopathy
Type 2 diabetes exposes the body to a state of high blood sugar for a long time and causes varying degrees of hardening of the arteries, making it more prone to cardiovascular emergencies.
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Article
Open AccessA simplified herbal decoction attenuates myocardial infarction by regulating macrophage metabolic reprogramming and phenotypic differentiation via modulation of the HIF-1α/PDK1 axis
Myocardial infarction (MI) poses a global public health challenge, often associated with elevated mortality rates and a grim prognosis. A crucial aspect of the inflammatory injury and healing process post-MI i...
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Article
Human amniotic epithelial stem cell is a cell therapy candidate for preventing acute graft-versus-host disease
Graft-versus-host disease (GVHD), an immunological disorder that arises from donor T cell activation through recognition of host alloantigens, is the major limitation in the application of allogeneic hematopoi...
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Article
Desloratadine ameliorates paclitaxel-induced peripheral neuropathy and hypersensitivity reactions in mice
Paclitaxel (PTX) serves as a primary chemotherapy agent against diverse solid tumors including breast cancer, lung cancer, head and neck cancer and ovarian cancer, having severe adverse effects including PTX-i...
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Article
Open AccessThe biomedical knowledge graph of symptom phenotype in coronary artery plaque: machine learning-based analysis of real-world clinical data
A knowledge graph can effectively showcase the essential characteristics of data and is increasingly emerging as a significant means of integrating information in the field of artificial intelligence. Coronary...
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Article
Bio-mediated geotechnology and its application in geoengineering: mechanism, approach, and performance
Bio-mediated geotechnology refers to the technology that utilizes various types of microbial processes to improve the hydro-mechanical behavior of soil and rock, aiming for the prevention and mitigation of geo...
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Article
Open AccessRisk factors for renal outcomes in children with antineutrophil cytoplasmic antibody-associated vasculitis: a nationwide retrospective study in China
Pediatric antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a life-threatening systemic vasculitis featured by liability to renal involvement. However, there are few studies on the risk factor...
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Article
Orientation controlled photogenerated carriers on self-supporting CdS/Ni3S2 paper toward photocatalytic hydrogen evolution and biomass upgrading
The appropriate regulation of band structure is an effective strategy in constructing efficient photocatalytic systems. Present photocatalytic system mainly employs powder photocatalysts, which makes their rec...
