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Open AccessDownregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its role in hepatocellular carcinoma (HCC) is unknown.
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Article
Involvement of proBDNF in Monocytes/Macrophages with Gastrointestinal Disorders in Depressive Mice
Major depressive disorders (MDD) are often comorbid with the gastrointestinal (GI) disorders. Brain-derived neurotrophic factor precursor (proBDNF) has been reported to contribute to the development of depress...
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Article
Down-regulation of Dicer and Ago2 is associated with cell proliferation and apoptosis in prostate cancer
Dicer and Argonaute2 (Ago2) are critical components responsible not only for RNA interference but also for microRNA synthesis. The present study investigated the roles of Dicer and Ago2 in prostate cancer (Pca...
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Article
Open AccessMolecular targets for PDE inhibitor-mediated improvement of cardiac dysfunction in the mdx mouse?
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Cardiac Aging
Cardiovascular diseases are the leading causes of death in the western world. The fact that cardiovascular mortality and morbidity rates increase exponentially in the elderly suggests that age per se is a majo...
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Open AccessSildenafil ameliorates cardiomyopathy in dystrophin-null (mdx) mice