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Article
Open AccessTBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro
There is a lack of effective therapeutic strategies for amyotrophic lateral sclerosis (ALS); therefore, drug repurposing might provide a rapid approach to meet the urgent need for treatment.
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Article
Open AccessAdvances in nuclear detection and readout techniques
“A Craftsman Must Sharpen His Tools to Do His Job,” said Confucius. Nuclear detection and readout techniques are the foundation of particle physics, nuclear physics, and particle astrophysics to reveal the nat...
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Article
Open AccessMass testing and characterization of 20-inch PMTs for JUNO
Main goal of the JUNO experiment is to determine the neutrino mass ordering using a 20 kt liquid-scintillator detector. Its key feature is an excellent energy resolution of at least 3% at 1 MeV, for which its ...
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Article
Open AccessDam** signatures at JUNO, a medium-baseline reactor neutrino oscillation experiment
We study dam** signatures at the Jiangmen Underground Neutrino Observatory (JUNO), a medium-baseline reactor neutrino oscillation experiment. These dam** signatures are motivated by various new physics mod...
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Article
Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies
Checkpoint kinase 1 inhibitors (CHK1i) have shown impressive single-agent efficacy in treatment of certain tumors, as monotherapy or potentiators of chemotherapy in clinical trials, but the sensitive tumor typ...
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Article
High Performance Electrospun Polynaphthalimide Nanofibrous Membranes with Excellent Resistance to Chemically Harsh Conditions
Polynaphthalimide (PNI) with six-membered imide ring (6-PI) has better chemical resistance than five-membered imide ring (5-PI), but is difficult to be processed into nanofibers due to the poor processability. In...
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Article
Open AccessRadioactivity control strategy for the JUNO detector
JUNO is a massive liquid scintillator detector with a primary scientific goal of determining the neutrino mass ordering by studying the oscillated anti-neutrino flux coming from two nuclear power plants at 53 ...
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Article
Open AccessThe design and sensitivity of JUNO’s scintillator radiopurity pre-detector OSIRIS
The OSIRIS detector is a subsystem of the liquid scintillator filling chain of the JUNO reactor neutrino experiment. Its purpose is to validate the radiopurity of the scintillator to assure that all components...
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Article
Open AccessJUNO sensitivity to low energy atmospheric neutrino spectra
Atmospheric neutrinos are one of the most relevant natural neutrino sources that can be exploited to infer properties about cosmic rays and neutrino oscillations. The Jiangmen Underground Neutrino Observatory ...
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Article
Open AccessCalibration strategy of the JUNO experiment
We present the calibration strategy for the 20 kton liquid scintillator central detector of the Jiangmen Underground Neutrino Observatory (JUNO). By utilizing a comprehensive multiple-source and multiple-posit...
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Article
Multi-stage glucose/pachymaran co-feeding enhanced endo-β-1,3-glucanase production by Trichoderma harzianum via simultaneous increases in cell concentration and inductive effect
Endo-β-1,3-glucanase is used to hydrolyze curdlan in a wide range of oligosaccharides production processes. Using pachymaran as the sole carbon source resulted in an endo-β-1,3-glucanase activity of 86.1 U/mL ...
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Article
Enhanced N-acetyl-d-neuraminic production from glycerol and N-acetyl-d-glucosamine by metabolically engineered Escherichia coli with a two-stage pH-shift control strategy
Typical N-acetyl-d-neuraminic acid (Neu5Ac) production uses N-acetyl-d-glucosamine (GlcNAc) and excess pyruvate as substrates in the enzymatic or whole-cell biocatalysis process. In a previous study, a Neu5Ac-pro...
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Chapter and Conference Paper
Application of Dimensionality-Reduction Algorithm in Interaction Action Recognition of Drivers
Human action recognition has many applications including design of human–machine system. Identifying the interaction between the driver and the vehicle information system is necessary to accurately identify th...
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Chapter and Conference Paper
Analysis of the Homogeneity of Driver Behaviors at Intersections
Intersections are road traffic accident-prone locations. About 10–40% of the traffic accidents take place at intersections worldwide every year. An intersection in Haidian District, Bei**g was surveyed by vid...
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Chapter and Conference Paper
Critical Safety Distance Model of Human-Vehicle Unit Based on Traffic Conflict at Urban Intersections
Traffic safety problem is one of the main problems faced by road traffic system, which attracts more and more attention of the society. Intersection is the bottleneck of the urban road traffic system. A large ...
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Article
Purification and characterization of a new endo-β-1,3-glucanase exhibiting a high specificity for curdlan for production of β-1,3-glucan oligosaccharides
Endo-β-1,3-glucanase (Endo23) was purified from a Trichoderma reesei GIMCC 3.498 fermentation broth using anion exchange and 2-stage size exclusion chromatography. Purification of 44.5× and a 12% recovery yield o...
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Article
A new effective process for production of curdlan oligosaccharides based on alkali-neutralization treatment and acid hydrolysis of curdlan particles in water suspension
Biologically active β-1,3-oligosaccharides with rapidly growing biomedical applications are produced from hydrolysis of curdlan polysaccharide. The water-insoluble curdlan impedes its hydrolysis efficiency whi...
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Article
Dihydroartemisinin inhibits angiogenesis in pancreatic cancer by targeting the NF-κB pathway
Dihydroartemisinin (DHA) has recently shown antitumor activity in human pancreatic cancer cells. However, its effect on antiangiogenic activity in pancreatic cancer is unknown, and the mechanism is unclear. Th...
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Article
Sequence and transcriptional analysis of the genes responsible for curdlan biosynthesis in Agrobacterium sp. ATCC 31749 under simulated dissolved oxygen gradients conditions
Expression at the mRNA level of ten selected genes in Agrobacterium sp. ATCC 31749 under various dissolved oxygen (DO) levels during curdlan fermentation related to electron transfer chain (ETC), tricarboxylic ac...
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Article
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