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    Article

    Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin

    Hypertension is a prominent contributor to vascular injury. Deubiquinatase has been implicated in the regulation of hypertension-induced vascular injury. In the present study we investigated the specific role ...

    Wan-te Lin, Yu-cheng Jiang, Yi-lin Mei, Yang-hao Chen in Acta Pharmacologica Sinica (2024)

  2. Article

    Open Access

    Dynamic single-cell map** unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response

    Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined...

    Miao-Zhen Qiu, Chaoye Wang, Zhiying Wu, Qi Zhao in Signal Transduction and Targeted Therapy (2023)

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    Article

    A Simple Echocardiographic Approach in Assessing the Prognosis of Comatose Patients with Acute Intracerebral Hemorrhage by Using Right Ventricle-Pulmonary Artery Coupling

    It remains a challenge to judge whether comatose patients with acute intracerebral hemorrhage (ICH) can wake up. Here, we aimed to investigate the changes in right ventricle-pulmonary artery (RV-PA) coupling o...

    Shang-Hua Zong, Li-Na Sun, **ao-Zhi Zheng in Neurocritical Care (2023)

  4. Article

    Open Access

    A Cohort Study on Deficiency of ADA2 from China

    Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in adenosine deaminase 2 (ADA2), has not been systemically investigat...

    Guo-min Li, Xu Han, Ye Wu, Wei Wang, Hong-xia Tang in Journal of Clinical Immunology (2023)

  5. Article

    Open Access

    UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development

    Genomic sequencing analysis of tumors provides potential molecular therapeutic targets for precision medicine. However, identifying a key driver gene or mutation that can be used for hepatocellular carcinoma (...

    Ren-Yu Zhang, Ze-Kun Liu, Ding Wei, Yu-Le Yong in Signal Transduction and Targeted Therapy (2021)

  6. No Access

    Article

    Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy

    Mechanisms of cardiomyopathy caused by obesity/hyperlipidemia are complicated. Obesity is usually associated with chronic low-grade inflammation and may lead to the onset and progression of myocardial fibrosis...

    Xu-yong Zheng, Chu-chu Sun, Qian Liu, **ao-yao Lu, Li-li Fu in Acta Pharmacologica Sinica (2020)

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    Article

    The evaluation of GI-pill gastrointestinal electronic capsule for colonic transit test in patients with slow transit constipation

    The evaluation of GI-pill gastrointestinal electronic capsule for colonic transit test in patients with slow transit constipation (STC) was studied.

    Yong-bing Wang, Gang Li, Yun-feng Wang in International Journal of Colorectal Disease (2020)

  8. Article

    Open Access

    Clostridium difficile carriage in hospitalized cancer patients: a prospective investigation in eastern China

    Clostridium difficile carriage has been considered as a potential source for the deadly infection, but its role in cancer patients is still unclear. We aimed to identify the clinical and immunological factors th...

    Wei-Jia Fang, Da-Zhi **g, Yun Luo, Cai-Yun Fu, Peng Zhao in BMC Infectious Diseases (2014)