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Article
Open AccessSerum dithiothreitol-oxidizing capacity (DOC) is a promising biomarker for excluding significant liver fibrosis: a proof-of-concept study
APRI and FIB-4 scores are used to exclude clinically significant fibrosis (defined as stage ≥ F2) in patients with chronic viral hepatitis. However, the cut-offs for these scores (generated by Youden indices) ...
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Article
Sp/sp2 carbon ratio-driven high-throughput screening of electrocatalytic nitrogen reduction performance on transition metal single-atom catalysts
Single-atom catalysts (SACs) have been widely utilized in electrochemical nitrogen reduction reactions (NRR) due to their high atomic utilization and selectivity. Owing to the unique sp/sp2 co-hybridization, grap...
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Article
Open AccessPrevalence and genetic diversity of Anaplasma and Ehrlichia in ticks and domesticated animals in Suizhou County, Hubei Province, China
Anaplasma and Ehrlichia are tick-borne bacterial pathogens that cause anaplasmoses and ehrlichioses in humans and animals. In this study, we examined the prevalence of Anaplasma and Ehrlichia species in ticks and...
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Article
Open AccessAntioxidant and anti-inflammatory function of Eupatorium adenophora Spreng leaves (EASL) on human intestinal Caco-2 cells treated with tert-butyl hydroperoxide
Chronic non-communicable diseases (CNCDs) pose a significant public health challenge. Addressing this issue, there has been a notable breakthrough in the prevention and mitigation of NCDs through the use of an...
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Article
Open AccessRisk factors for renal outcomes in children with antineutrophil cytoplasmic antibody-associated vasculitis: a nationwide retrospective study in China
Pediatric antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a life-threatening systemic vasculitis featured by liability to renal involvement. However, there are few studies on the risk factor...
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Article
Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin
Hypertension is a prominent contributor to vascular injury. Deubiquinatase has been implicated in the regulation of hypertension-induced vascular injury. In the present study we investigated the specific role ...
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Article
Towards High-Performance Graph Processing: From a Hardware/Software Co-Design Perspective
Graph processing has been widely used in many scenarios, from scientific computing to artificial intelligence. Graph processing exhibits irregular computational parallelism and random memory accesses, unlike t...
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Article
Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n
Nondestructive and noninvasive neutron assays are essential applications of neutron techniques. Neutron resonance transmission analysis (NRTA) is a powerful nondestructive method for investigating the elementa...
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Article
Open AccessAge-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis
Increased oxidative stress contributes to enhanced osteoclastogenesis and age-related bone loss. Melatonin (MT) is an endogenous antioxidant and declines with aging. However, it was unclear whether the decline...
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Chapter and Conference Paper
Reliability-Based Design of Minimum Safe Net Distance Between Small-Space Tunnels
Due to the low occupation of land and the suitability in environmental protection, small-space tunnels are widely used in underpass projects in urban expressways. The determination of the minimum safe net dist...
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Article
ZNF689 deficiency promotes intratumor heterogeneity and immunotherapy resistance in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is an aggressive disease characterized by remarkable intratumor heterogeneity (ITH), which poses therapeutic challenges. However, the clinical relevance and key determinant...
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Article
Open AccessDynamic single-cell map** unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response
Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined...
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Article
A combined method for simulating track irregularities with full information and small samples
In order to improve the accuracy and efficiency of the train-track-bridge coupled system (TTBS) dynamics random analysis under the excitation of track irregularities, a full information representation of the t...
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Article
Ambient PM2.5-bound polycyclic aromatic hydrocarbons in Ningbo Harbor, eastern China: seasonal variation, source apportionment, and cancer risk assessment
Field measurements were conducted at a container harbor located in Ningbo-Zhoushan Port, China. Concentrations of fifty-three PAHs in airborne PM2.5 were quantified using gas chromatography-mass spectrometry (GC-...
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Article
Open AccessExploration of KIR genes and hematological-related diseases in Chinese Han population
The function of natural killer (NK) cells has previously been implicated in hematopoietic-related diseases. Killer immunoglobulin-like receptors (KIR) play an important role in NK cells after hematopoietic ste...
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Article
A Simple Echocardiographic Approach in Assessing the Prognosis of Comatose Patients with Acute Intracerebral Hemorrhage by Using Right Ventricle-Pulmonary Artery Coupling
It remains a challenge to judge whether comatose patients with acute intracerebral hemorrhage (ICH) can wake up. Here, we aimed to investigate the changes in right ventricle-pulmonary artery (RV-PA) coupling o...
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Article
Open AccessComplex phase transitions and phase engineering in the aqueous solution of an isopolyoxometalate cluster
Inorganic salts usually demonstrate simple phasal behaviors in dilute aqueous solution mainly involving soluble (homogeneous) and insoluble (macrophase separation) scenarios. Herein, we report the discovery of...
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Article
Open AccessA Cohort Study on Deficiency of ADA2 from China
Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in adenosine deaminase 2 (ADA2), has not been systemically investigat...
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Article
Open AccessDopant triggered atomic configuration activates water splitting to hydrogen
Finding highly efficient hydrogen evolution reaction (HER) catalysts is pertinent to the ultimate goal of transformation into a net-zero carbon emission society. The design principles for such HER catalysts li...
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Article
Open AccessGlobal, regional, and national burdens of myocarditis, 1990–2019: systematic analysis from GBD 2019
Myocarditis, a health-threatening heart disease, is attracting increasing attention. This systematic study was conducted to study the prevalence of disease through the trends of incidence, mortality, disabilit...
