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  1. No Access

    Article

    Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E–deficient mice

    Urolithin A (UroA), a dietary phytochemical, is produced by gut bacteria from fruits rich in natural polyphenols ellagitannins (ETs). The efficiency of ETs metabolism to UroA in humans depends on gut microbiot...

    Meng-yun Xu, **g-**g Xu, Li-**g Kang, Zheng-hong Liu… in Acta Pharmacologica Sinica (2024)

  2. No Access

    Article

    Metabolomic profiling of maternal plasma identifies inverse associations of acetate and urea with anti-SARS-CoV-2 antibody titers following COVID-19 vaccination during pregnancy

    We conducted a comprehensive metabolomic analysis of plasma samples obtained from pregnant women who displayed varying post-vaccination antibody titers after receiving mRNA-1273-SARS-CoV-2 vaccines. The study ...

    An-Shine Chao, Chiao-Yun Lin, Meng-Han Chiang… in Journal of Molecular Medicine (2024)

  3. No Access

    Article

    zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function

    CD80 is a transmembrane glycoprotein belonging to the B7 family, which has emerged as a crucial molecule in T cell modulation via the CD28 or CTLA4 axes. CD80-involved regulation of immune balance is a finely ...

    Bin Lu, Yi-yun Sun, Bo-ya Chen, Bo Yang, Qiao-jun He, Jun Li… in Acta Pharmacologica Sinica (2024)

  4. No Access

    Article

    Synthesis and preliminary evaluation of novel 11C-labeled GluN2B-selective NMDA receptor negative allosteric modulators

    N-methyl-D-aspartate receptors (NMDARs) play critical roles in the physiological function of the mammalian central nervous system (CNS), including learning, memory, and synaptic plasticity, through modulating exc...

    Ji-yun Sun, Katsushi Kumata, Zhen Chen, Yi-ding Zhang… in Acta Pharmacologica Sinica (2021)

  5. No Access

    Article

    Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R

    Colony-stimulating factor 1 receptor (CSF1R) plays a critical role in promoting tumor progression in various types of tumors. Here, we identified D2923 as a novel and selective inhibitor of CSF1R and explored ...

    Ying-Qiang Liu, Ya-Nan Wang, **ao-Yun Lu, Lin-Jiang Tong… in Acta Pharmacologica Sinica (2018)

  6. Article

    MicroRNA expression profile and functional analysis reveal their roles in contact inhibition and its disruption switch of rat vascular smooth muscle cells

    Contact inhibition and its disruption of vascular smooth muscle cells (VSMCs) are important cellular events in vascular diseases. But the underlying molecular mechanisms are unclear. In this study we investiga...

    Ye-ying Sun, Shan-shan Qin, Yun-hui Cheng, Chao-yun Wang… in Acta Pharmacologica Sinica (2018)

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  7. No Access

    Article

    Poly-l-Arginine Acts Synergistically with LPS to Promote the Release of IL-6 and IL-8 via p38/ERK Signaling Pathways in NCI-H292 Cells

    Major basic protein (MBP) derived from activated eosinophil can exacerbate atopic asthma induced by lipopolysaccharide (LPS). The pharmacological function of MBP can be mimicked by poly-l-arginine (PLA), however,...

    **ao-Yun Fan, Bing Chen, Zhao-Shuang Lu, Zi-Feng Jiang, Sheng-Quan Zhang in Inflammation (2016)

  8. Article

    Development of β-amino-carbonyl compounds as androgen receptor antagonists

    Androgen receptor (AR) antagonists have proven to be useful in the early control of prostate cancer. The aim of this study was to identify and characterize a novel β-amino-carbonyl-based androgen receptor anta...

    Zhi-yun Zhang, Yan-hui Zhu, Cai-hong Zhou, Qing Liu… in Acta Pharmacologica Sinica (2014)

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  9. Article

    The immunosuppressive effect of gossypol in mice is mediated by inhibition of lymphocyte proliferation and by induction of cell apoptosis

    To investigate the immunosuppressive effect of gossypol in mice both in vitro and in vivo.

    Wen-bin Xu, Li-hui Xu, Hong-song Lu, Dong-yun Ou-Yang… in Acta Pharmacologica Sinica (2009)

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  10. No Access

    Article

    Poster abstracts

    J. Ferrie, M. Shipley, F. Cappuccio, E. Brunner, M. Miller… in Sleep and Biological Rhythms (2007)

  11. Article

    Evaluation of 2 celecoxib derivatives: analgesic effect and selectivity to cyclooxygenase-2/1

    To evaluate the analgesic effects of 2 celecoxib derivatives and their inhibitory effects on cyclooxygenase (COX).

    Zhi-hong Lu, **ao-yun **ong, Bang-le Zhang, Guo-cheng Lin… in Acta Pharmacologica Sinica (2005)

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