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Generation of genetic engineering monoclonal antibodies against prion protein

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  1. Article

    Evaluation of 2 celecoxib derivatives: analgesic effect and selectivity to cyclooxygenase-2/1

    To evaluate the analgesic effects of 2 celecoxib derivatives and their inhibitory effects on cyclooxygenase (COX).

    Zhi-hong Lu, **ao-yun **ong, Bang-le Zhang, Guo-cheng Lin in Acta Pharmacologica Sinica (2005)

  2. Article

    The immunosuppressive effect of gossypol in mice is mediated by inhibition of lymphocyte proliferation and by induction of cell apoptosis

    To investigate the immunosuppressive effect of gossypol in mice both in vitro and in vivo.

    Wen-bin Xu, Li-hui Xu, Hong-song Lu, Dong-yun Ou-Yang in Acta Pharmacologica Sinica (2009)

  3. Article

    Open Access

    The association of XRCC1gene single nucleotide polymorphisms with response to neoadjuvant chemotherapy in locally advanced cervical carcinoma

    Platinum-based neoadjuvant chemotherapy (NAC) is new therapeutic strategy for locally advanced cervical carcinoma, but the variables used to predict NAC response are still infrequently reported. The aim of our...

    **ao-Dong Cheng, Wei-Guo Lu, Feng Ye in Journal of Experimental & Clinical Cancer … (2009)

  4. Article

    Development of β-amino-carbonyl compounds as androgen receptor antagonists

    Androgen receptor (AR) antagonists have proven to be useful in the early control of prostate cancer. The aim of this study was to identify and characterize a novel β-amino-carbonyl-based androgen receptor anta...

    Zhi-yun Zhang, Yan-hui Zhu, Cai-hong Zhou, Qing Liu in Acta Pharmacologica Sinica (2014)

  5. Article

    Open Access

    Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia

    Pediatric acute myeloid leukemia (AML) comprises up to 20% of all childhood leukemia. Recent research shows that aberrant DNA methylation patterning may play a role in leukemogenesis. The epigenetic silencing ...

    Yan-Fang Tao, Li-**ao Xu, Jun Lu in Journal of Experimental & Clinical Cancer … (2015)

  6. Article

    MicroRNA expression profile and functional analysis reveal their roles in contact inhibition and its disruption switch of rat vascular smooth muscle cells

    Contact inhibition and its disruption of vascular smooth muscle cells (VSMCs) are important cellular events in vascular diseases. But the underlying molecular mechanisms are unclear. In this study we investiga...

    Ye-ying Sun, Shan-shan Qin, Yun-hui Cheng, Chao-yun Wang in Acta Pharmacologica Sinica (2018)