-
Article
Open AccessGLP-1 receptor agonists’ impact on cardio-renal outcomes and mortality in T2D with acute kidney disease
Previous studies have explored the effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in reducing cardiovascular events in type 2 diabetes. Here we show that GLP-1 RAs are associated with lower r...
-
Article
Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction
Cardiac fibrosis is a pathological scarring process that impairs cardiac function. N-acetyltransferase 10 (Nat10) is recently identified as the key enzyme for the N4-acetylcytidine (ac4C) modification of mRNAs...
-
Article
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
-
Article
Open AccessHousekee** protein-coding genes interrogated with tissue and individual variations
Housekee** protein-coding genes are stably expressed genes in cells and tissues that are thought to be engaged in fundamental cellular biological functions. They are often utilized as normalization reference...
-
Article
Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes
The High Altitude Detection of Astronomical Radiation (HADAR) experiment, which was constructed in Tibet, China, combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity ...
-
Article
Supramolecular systems for bioapplications: recent research progress in China
Supramolecular systems feature dynamic, reversible and stimuli-responsive characteristics, which are not easily achieved by molecular entities. The last decade has witnessed tremendous advances in the investig...
-
Article
Different wavelengths of LED irradiation promote secondary metabolite production in Pycnoporus sanguineus for antioxidant and immunomodulatory applications
Pycnoporus sanguineus is a fungus of the phylum Basidiomycota that has many applications in traditional medicine, modern pharmaceuticals, and agricultural industries. Light plays an essential role in the metaboli...
-
Article
Creation of memory–memory entanglement in a metropolitan quantum network
Towards realizing the future quantum internet1,2, a pivotal milestone entails the transition from two-node proof-of-principle experiments conducted in laboratories to comprehensive multi-node set-ups on large sca...
-
Article
Comparative efficacy of alkaline slag, biomass ash, and biochar application for the amelioration of different acidic soils
This study aimed at comparing the multi-functions of by-product amendments for ameliorating acidic soils, namely, liming effect, aluminum immobilization and fertility improvement.
-
Article
Open AccessMulti-modal molecular determinants of clinically relevant osteoporosis subtypes
Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become a wide-spread public health problem. However, osteoporosis is very heterogeneous, and the existing s...
-
Article
Prenatal exposures to phthalates and bisphenols in relation to oxidative stress: single pollutant and mixtures analyses
Prenatal exposures to phthalates and bisphenols have been shown to be linked with adverse birth outcomes. Oxidative stress (OS) is considered a potential mechanism. The objective of this study was to explore t...
-
Article
Preparation of vanadium-based electrode materials and their research progress in solid-state flexible supercapacitors
Solid-state flexible supercapacitors (SCs) have many advantages of high specific capacitance, excellent flexibility, fast charging and discharging, high power density, environmental friendliness, high safety, ...
-
Article
Open AccessAuthor Correction: Tandem gene duplications contributed to high-level azole resistance in a rapidly expanding Candida tropicalis population
-
Article
Strengthening mechanism of steel fiber in UHPC: A new fracture phase field model
The engineering optimization of ultra-high strength concrete (UHPC) requires urgent exploration of the strengthening mechanism of steel fiber in UHPC and the establishment of an effective simulation model. In ...
-
Article
Open AccessA novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge
Human enteroviruses A71 (EV-A71) and D68 (EV-D68) are the suspected causative agents of hand-foot-and-mouth disease, aseptic meningitis, encephalitis, acute flaccid myelitis, and acute flaccid paralysis in chi...
-
Article
Open AccessTandem gene duplications contributed to high-level azole resistance in a rapidly expanding Candida tropicalis population
Invasive diseases caused by the globally distributed commensal yeast Candida tropicalis are associated with mortality rates of greater than 50%. Notable increases of azole resistance have been observed in this sp...
-
Article
Open AccessMultidrug-resistant organisms may be associated with bed allocation and utilization efficiency in healthcare institutions, based on national monitoring data from China (2014–2020)
Analyzing the influence of the bed allocation and utilization efficiency in healthcare institutions on the isolation proportion of Multidrug-resistant organisms (MDROs) to provide data to support prevention an...
-
Article
Open AccessProteomic characterization of epithelial ovarian cancer delineates molecular signatures and therapeutic targets in distinct histological subtypes
Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear....
-
Article
High cycle fatigue behavior of titanium microalloyed high-strength beam steels
The realization of an ideal combination of mechanical and fatigue properties is prerequisites for practical application of titanium (Ti) microalloyed steel in automotive field. The fatigue behavior of four Ti ...
-
Article
Two-thiols-regulated fabrication of plasmonic nanoparticles with co-enhanced Raman scattering and circular dichroism responses
Plasmonic nanoparticles (PNPs) with stable nanogaps are important to achieve strong, uniform and quantitative gap-enhanced Raman scattering (GERS) signals. Chiral PNPs with plasmonic circular dichroism (PCD) r...
