28 Result(s)

Article

Evaluation of 2 celecoxib derivatives: analgesic effect and selectivity to cyclooxygenase-2/1

To evaluate the analgesic effects of 2 celecoxib derivatives and their inhibitory effects on cyclooxygenase (COX).

Zhi-hong Lu, **ao-yun **ong, Bang-le Zhang, Guo-cheng Lin… in Acta Pharmacologica Sinica (2005)

Article

Disease burden and related medical costs of rotavirus infections in Taiwan

The disease burden and associated medical costs of rotavirus infections in inpatient and outpatient sectors in Taiwan were examined in anticipation of the availability of new rotavirus vaccines.

Chun-Yi Lu, Tsai-Ling Lauderdale, Yin-Hua Fang, Chung-Yi Wang… in BMC Infectious Diseases (2006)

Article

Identification of human dopamine receptors agonists from Chinese herbs

To find human dopamine receptors, especially D1-like receptor specific agonists from Chinese herbs as potential antihypertension drug leads.

Yi-lin Zhang, Hai-qing Zhang, **ao-yu Liu, Shi-neng Hua… in Acta Pharmacologica Sinica (2007)

Article

Fibrinogen interaction of CHO cells expressing chimeric αIIb/αvβ3 integrin

The molecular mechanisms of the affinity regulation of αvβ3 integrin are important in tumor development, wound repairing, and angiogenesis. It has been established that the cytoplasmic domains of αvβ3 integrin...

Juan-juan Chen, **ao-yu Su, **ao-dong **, Li-** Lin… in Acta Pharmacologica Sinica (2008)

Article

Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin

Hepatic glycogen phosphorylase (GP) and glucose-6-phosphatase (G6Pase) play an important role in the control of blood glucose homeostasis and are proposed to be potential targets for anti-diabetic drugs. Genip...

Shao-yu Wu, Guang-fa Wang, Zhong-qiu Liu, **-jun Rao, Lin Lü… in Acta Pharmacologica Sinica (2009)

Article

Genipin inhibits endothelial exocytosis via nitric oxide in cultured human umbilical vein endothelial cells

Exocytosis of endothelial Weibel-Palade bodies, which contain von Willebrand factor (VWF), P-selectin and other modulators, plays an important role in both inflammation and thrombosis. The present study invest...

Guang-fa Wang, Shao-yu Wu, **-jun Rao, Lin Lü, Wei Xu… in Acta Pharmacologica Sinica (2009)

Article

Predictors of failure of conservative treatment among patients with emphysematous pyelonephritis

Emphysematous pyelonephritis (EPN) is a severe necrotizing infection of the renal parenchyma and perirenal tissues that is caused by gas-producing bacterial pathogens. Percutaneous drainage is now the gold sta...

Yu-Chuan Lu, Bing-Juin Chiang, Yuan-Hung Pong, Kuo-How Huang… in BMC Infectious Diseases (2014)

Article

Wave reflections, arterial stiffness, heart rate variability and orthostatic hypotension

Increased arterial stiffness and wave reflections are independently associated with orthostatic hypotension (OH). This study investigated whether heart rate variability (HRV) is also involved in the modulation...

Dai-Yin Lu, Shih-Hsien Sung, Wen-Chung Yu, Hao-Min Cheng… in Hypertension Research (2014)

Article

Discovery and structural optimization of 4-(4-(benzyloxy)phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists

Retinoic acid receptor-related orphan nuclear receptors (RORs) are orphan nuclear receptors that show constitutive activity in the absence of ligands. Among 3 subtypes of RORs, RORc is a promising therapeutic ...

**-shan Wu, Rui Wang, Yan-li **ng, **ao-qian Xue, Yan Zhang… in Acta Pharmacologica Sinica (2016)

Article

World Congress Integrative Medicine & Health 2017: part two

Carolyn Ee, Sharmala Thuraisingam… in BMC Complementary and Alternative Medicine (2017)

Article

Epidemiology and outcomes of Endophthalmitis in chronic dialysis patients: a 13-year experience in a tertiary referral center in Taiwan

Endophthalmitis is a severe eye infection leading to disabling outcome. Because there were only a few case report illustrating endophthalmitis in chronic dialysis patient, we would like to investigate the epid...

George Kuo, Yueh-An Lu, Wei-Chiao Sun, Chao-Yu Chen, Huang-Kai Kao… in BMC Nephrology (2017)

Article

Homocysteine is a bystander for ST-segment elevation myocardial infarction: a case-control study

Homocysteine has been long considered a risk factor for atherosclerosis. However, cardiovascular events cannot be reduced through homocysteine lowering by B vitamin supplements. Although several association st...

Ching-Yu Julius Chen, Tzu-Ching Yang, Christopher Chang… in BMC Cardiovascular Disorders (2018)

Article

Antrodia cinnamomea extract inhibits the proliferation of tamoxifen-resistant breast cancer cells through apoptosis and skp2/microRNAs pathway

Breast cancer is the most common cancer in women and affects 1.38 million women worldwide per year. Antiestrogens such as tamoxifen, a selective estrogen receptor (ER) modulator, are widely used in clinics to ...

Yu-Shih Lin, Yin-Yin Lin, Yao-Hsu Yang… in BMC Complementary and Alternative Medicine (2018)

Article

Multiparametric ultrasomics of significant liver fibrosis: A machine learning-based analysis

To assess significant liver fibrosis by multiparametric ultrasomics data using machine learning.

Wei Li, Yang Huang, Bo-Wen Zhuang, Guang-Jian Liu, Hang-Tong Hu… in European Radiology (2019)

Article

Probiotics may not prevent the deterioration of necrotizing enterocolitis from stage I to II/III

Probiotic therapy can reduce the incidence of NEC. Therapeutic use of probiotics after NEC diagnosis reduces the severity of NEC in preterm infants or full-term infants is unclear. To evaluate the effect of pr...

Zheng-Li Wang, Li Liu, **ao-Yu Hu, Lu Guo, Qiu-Yu Li, Yao An… in BMC Pediatrics (2019)

Article

Identifying risk groups of infectious spondylitis in patients with end-stage renal disease under hemodialysis: a propensity score-matched case-control study

Patients with end-stage renal disease (ESRD) under hemodialysis (HD) are at greater risks of infectious spondylitis (IS), but there is no reliable predictor that facilitate early detection of this relatively r...

Kun-Lin Lu, Wen-Hung Huang, Yueh-An Lu, Chan-Yu Lin, Hsin-Hsu Wu… in BMC Nephrology (2019)

Article

Microscopic features of small bowel mucosa of patients with Crohn’s disease

Double-balloon enteroscopy enables performing numerous small bowel biopsies for pathologic analysis. However, most histopathological characteristics of Crohn’s disease are non-specific characteristics. We aime...

Yun Cui, Shi-yuan Lu, Jie Xu, Yan-shen Peng, Qi Miao… in BMC Gastroenterology (2019)

Article

Low value of whole-body dual-modality [18f]fluorodeoxyglucose positron emission tomography/computed tomography in primary staging of stage I–II nasopharyngeal carcinoma: a nest case-control study

The value of using PET/CT for staging of stage I–II NPC remains unclear. Hence, we aimed to investigate the survival benefit of PET/CT for staging of early-stage NPC before radical therapy.

Bei-Bei **ao, Qiu-Yan Chen, Xue-Song Sun, Ji-Bin Li, Dong-hua Luo… in European Radiology (2021)

Article

Correlation of MKI67 with prognosis, immune infiltration, and T cell exhaustion in hepatocellular carcinoma

MKI67 plays a vital role in the tumour microenvironment (TME) and congenital immunity. The present work focuses on exploring the prognosis prediction performance of MKI67 and its associations with T cell activ...

Shi-yi Wu, Pan Liao, Lu-yu Yan, Qian-yi Zhao, Zhao-yu **e, Jie Dong… in BMC Gastroenterology (2021)

Article

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

Azvudine (FNC) is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase (RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into Phase III trial for COVID-19 patie...

**-Lan Zhang, Yu-Huan Li, Lu-Lu Wang… in Signal Transduction and Targeted Therapy (2021)