47 Result(s)
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Article
Representative appressorium stage cDNA library of Magnaporthe grisea
A mature appressorium cDNA library of rice blast fungus, Magnaporthe grisea was constructed in a λ TriplEx2 vector by SMART™ cDNA library containing 2.37×106 independent clones about 100% of which harbor foreign ...
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Article
Sequence analysis and expression pattern ofMGTA1 gene in rice blast pathogenMagnaporthe grisea
MGTA1, a putative fungal Zn(II)2Cys6 transcriptional activator-encoding gene, was isolated from rice blast pathogenMagnaporthe grisea, which is homologous toCLTA1 fromColletotrichum lindemuthianum with 51% identi...
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Article
Evaluation of 2 celecoxib derivatives: analgesic effect and selectivity to cyclooxygenase-2/1
To evaluate the analgesic effects of 2 celecoxib derivatives and their inhibitory effects on cyclooxygenase (COX).
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Article
Structural changes of oviduct of freshwater shrimp, Macrobrachium nipponense (Decapoda, Palaemonidae), during spawning
The structural change of the oviduct of freshwater shrimp (Macrobrachium nipponense) during spawning was examined by electron microscopy. The oviduct wall structural characteristics seem to be influenced signific...
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Article
Promoter trap** in Magnaporthe grisea
Application of promoter trap** based on transformation in Magnaporthe grisea is reported in this paper. Two promoter-trap** vectors, designated as pCBGFP and pEGFPHPH, were constructed and transformed into pr...
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Article
Identification of human dopamine receptors agonists from Chinese herbs
To find human dopamine receptors, especially D1-like receptor specific agonists from Chinese herbs as potential antihypertension drug leads.
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Article
Fibrinogen interaction of CHO cells expressing chimeric αIIb/αvβ3 integrin
The molecular mechanisms of the affinity regulation of αvβ3 integrin are important in tumor development, wound repairing, and angiogenesis. It has been established that the cytoplasmic domains of αvβ3 integrin...
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A preliminary study on the teratogenesis of dexamethasone and the preventive effect of vitamin B12 on murine embryonic palatal shelf fusion in vitro
Excessive dexamethasone (Dex) administrated into pregnant mice during critical periods of palatal development can produce a high incidence of cleft palate. Its mechanisms remain unknown. Vitamin B12 has been show...
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Article
Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin
Hepatic glycogen phosphorylase (GP) and glucose-6-phosphatase (G6Pase) play an important role in the control of blood glucose homeostasis and are proposed to be potential targets for anti-diabetic drugs. Genip...
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Article
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21
Xuejun Zhang and colleagues report a genome-wide association and replication studies for psoriasis, conducted in Chinese populations. They confirm previous associations in MHC and IL12B to psoriasis susceptibilit...
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Article
Genipin inhibits endothelial exocytosis via nitric oxide in cultured human umbilical vein endothelial cells
Exocytosis of endothelial Weibel-Palade bodies, which contain von Willebrand factor (VWF), P-selectin and other modulators, plays an important role in both inflammation and thrombosis. The present study invest...
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Article
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
Xuejun Zhang and colleagues report results of a genome-wide association study of systemic lupus erythematosus (SLE) in a Chinese Han population. Their work identifies nine new SLE susceptibility loci and revea...
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Article
Open AccessHerbal compound "Songyou Yin" reinforced the ability of interferon-alfa to inhibit the enhanced metastatic potential induced by palliative resection of hepatocellular carcinoma in nude mice
Liver resection is a widely accepted treatment for hepatocellular carcinoma (HCC). Our previous clinical study showed that the rate of palliative resection was 34.0% (1958-2008, 2754 of 8107). However, the inf...
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Open AccessAntiangiogenic effects of pazopanib in xenograft hepatocellular carcinoma models: evaluation by quantitative contrast-enhanced ultrasonography
Antiangiogenesis is a promising therapy for advanced hepatocellular carcinoma (HCC), but the effects are difficult to be evaluated. Pazopanib (GW786034B) is a pan-vascular endothelial growth factor receptor in...
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Open AccessThe independent, unfavorable prognostic factors endothelin A receptor and chemokine receptor 4 have a close relationship in promoting the motility of nasopharyngeal carcinoma cells via the activation of AKT and MAPK pathways
Recent studies have indicated that the expression of endothelin A receptor (ETAR) and chemokine receptor 4 (CXCR4) could be used as an indicator of the metastatic potential of nasopharyngeal carcinoma (NPC). T...
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Article
Genetic variations in TP53 binding sites are predictors of clinical outcomes in prostate cancer patients
Since the tumor protein p53 (TP53), a transcription factor, plays a crucial role in prostate cancer development and progression, we hypothesized that sequence variants in TP53 binding sites might affect clinic...
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Article
Identification and characterization of SlVKOR, a disulfide bond formation protein from Solanum lycopersicum, and bioinformatic analysis of plant VKORs
Homologs of vitamin K epoxide reductase (VKOR) exist widely in plants. However, only VKOR of Arabidopsis thaliana has been the subject of many studies to date. In the present study, the coding region of a VKOR fr...
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Open AccessChinese medicine combined with calcipotriol betamethasone and calcipotriol ointment for Psoriasis vulgaris (CMCBCOP): study protocol for a randomized controlled trial
Psoriasis causes worldwide concern because of its high-prevalence, as well as its harmful, and incurable characteristics. Topical therapy is a conventional treatment for psoriasis vulgaris. Chinese medicine (C...
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Article
Open AccessThe impact of the cumulative dose of cisplatin during concurrent chemoradiotherapy on the clinical outcomes of patients with advanced-stage nasopharyngeal carcinoma in an era of intensity-modulated radiotherapy
The impact of cumulative dose of cisplatin on clinical outcomes of nasopharyngeal carcinoma (NPC) patients who received intensity-modulated radiotherapy (IMRT) was evaluated.
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Article
Open AccessA pilot study to determine the timing and effect of bevacizumab on vascular normalization of metastatic brain tumors in breast cancer
To determine the appropriate time of concomitant chemotherapy administration after antiangiogenic treatment, we investigated the timing and effect of bevacizumab administration on vascular normalization of met...
