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  1. Article

    Publisher Correction: E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

    Chun-yan Duan, Yue Li, Hao-yu Zhi, Yao Tian, Zheng-yun Huang in Acta Pharmacologica Sinica (2024)

  2. No Access

    Article

    E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

    The circadian clock is the inner rhythm of life activities and is controlled by a self-sustained and endogenous molecular clock, which maintains a ~ 24 h internal oscillation. As the core element of the circad...

    Chun-yan Duan, Yue Li, Hao-yu Zhi, Yao Tian, Zheng-yun Huang in Acta Pharmacologica Sinica (2024)

  3. Article

    Open Access

    Author Correction: Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF-κB/AQP8 pathway

    Peng-yu Duan, Yuan Ma, **-na Li, Feng-zhi Qu, Liang Ji in Experimental & Molecular Medicine (2024)

  4. No Access

    Article

    Phenome-wide association study and precision medicine of cardiovascular diseases in the post-COVID-19 era

    SARS-CoV-2 infection causes injuries of not only the lungs but also the heart and endothelial cells in vasculature of multiple organs, and induces systemic inflammation and immune over-reactions, which makes C...

    Qian Cao, **n Du, **ao-yan Jiang, Yuan Tian, Chen-hao Gao in Acta Pharmacologica Sinica (2023)

  5. No Access

    Article

    Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression

    Recent studies show that liver X receptor (LXR) agonists exert significant antitumor effects in a variety of tumor cell lines including hepatocellular carcinoma (HCC). But the molecular mechanisms underlying L...

    **ao-yu He, Meng-meng Zhu, Juan Zheng, Cheng-yi Wang in Acta Pharmacologica Sinica (2023)

  6. Article

    Open Access

    Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF-κB/AQP8 pathway

    Currently, preliminary results have confirmed the existence of receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL)-dependent necroptosis of pancreatic acinar cells...

    Peng-yu Duan, Yuan Ma, **-na Li, Feng-zhi Qu, Liang Ji in Experimental & Molecular Medicine (2019)

  7. Article

    Apoptosis induced by diallyl disulfide in human breast cancer cell line MCF-7

    To investigate the effect of diallyl disulfide (DADS), a component of garlic, on apoptosis in human mammary cancer cell line (MCF-7) and its mechanisms.

    **ao-yong Lei, Shu-qiong Yao, Xu-yu Zu, Ze-xiang Huang in Acta Pharmacologica Sinica (2008)

  8. Article

    Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells

    To investigate the protective effect and the possible mechanism of curcumin on anti-atherosclerosis.

    Hao-yu Yuan, Shuang-yu Kuang, **ng Zheng, Hong-yan Ling in Acta Pharmacologica Sinica (2008)

  9. Article

    Heat shock protein 90 acts as a molecular chaperone in late-phase activation of extracellular signal-regulated kinase 1/2 stimulated by oxidative stress in vascular smooth muscle cells

    To investigate whether cytosolic heat shock protein 90 (HSP90) acts as a molecular chaperone on the activated extracellular signal-regulated kinase 1/2 (ERK1/2) and cell proliferation stimulated by reactive ox...

    Dai-hua Liu, Hao-yu Yuan, Chun-ya Cao, Zhi-** Gao in Acta Pharmacologica Sinica (2007)