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Article
Open AccessAuthor Correction: Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF-κB/AQP8 pathway
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Article
Effect of friction stir processing on microstructure and friction and wear properties of as-cast SiCp/ZL101 composites
Friction stir lap welding (FSLW) was used to weld as-cast SiCp/ZL101 composite plate and ZL101 alloy plate to prepare a new brake disc material, and the as-cast SiCp/ZL101 composite plate was modified by friction...
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Article
(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission
Epilepsy is one common brain disorder, which is not well controlled by current pharmacotherapy. In this study we characterized the therapeutic potential of borneol, a plant-derived bicyclic monoterpene compoun...
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Article
Open AccessLILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis
Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) and its human ortholog recept...
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Article
Open AccessThe efficacy and safety of apatinib plus capecitabine in platinum-refractory metastatic and/or recurrent nasopharyngeal carcinoma: a prospective, phase II trial
Previous studies have shown that monotherapy with apatinib, an oral tyrosine kinase inhibitor, has promising efficacy for treating recurrent or metastatic (RM) nasopharyngeal carcinoma (NPC) patients. In this ...
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Article
Casticin Attenuates Stemness in Cervical Cancer Stem-Like Cells by Regulating Activity and Expression of DNMT1
To explore whether casticin (CAS) suppresses stemness in cancer stem-like cells (CSLCs) obtained from human cervical cancer (CCSLCs) and the underlying mechanism.
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Article
A Macroporous Cryogel with Enhanced Mechanical Properties for Osteochondral Regeneration In vivo
The dense networks of conventional hydrogel hinder the efficient cell penetration and thus tissue regeneration. In this study, a macroporous cryogel with excellent mechanical properties was designed and fabric...
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Article
Open AccessThe crosstalk between endothelial cells and vascular smooth muscle cells aggravates high phosphorus-induced arterial calcification
Arterial calcification is highly prevalent, particularly in patients with end-stage renal disease (ESRD). The osteogenic differentiation of vascular smooth muscle cells (VSMCs) is the critical process for the ...
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Article
Open AccessConvergent and divergent gray matter volume abnormalities in unaffected first-degree relatives and ultra-high risk individuals of schizophrenia
High-risk populations of schizophrenia can be mainly identified as genetic high-risk based on putative endophenotypes or ultra-high-risk (UHR) based on clinically manifested symptoms. Previous studies have con...
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Article
Open AccessATG7-enhanced impaired autophagy exacerbates acute pancreatitis by promoting regulated necrosis via the miR-30b-5p/CAMKII pathway
The present study was performed to explore whether and how impaired autophagy could modulate calcium/calmodulin-dependent protein kinase II (CAMKII)-regulated necrosis in the pathogenesis of acute pancreatitis...
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Article
Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies
Checkpoint kinase 1 inhibitors (CHK1i) have shown impressive single-agent efficacy in treatment of certain tumors, as monotherapy or potentiators of chemotherapy in clinical trials, but the sensitive tumor typ...
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Article
Open AccessCorrection to: Downregulation of miR-223 promotes HMGB2 expression and induces oxidative stress to activate JNK and promote autophagy in an in vitro model of acute lung injury
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Article
Interdiscipline between optoelectronic materials and mechanical sensors: Recent advances of organic triboluminescent compounds and their applications in sensing
Triboluminescence, also as known as mechanoluminescence, is an attractive optical behavior that means the light emitted from specific organic and inorganic materials when they are subjected to external forces,...
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Article
High Performance Electrospun Polynaphthalimide Nanofibrous Membranes with Excellent Resistance to Chemically Harsh Conditions
Polynaphthalimide (PNI) with six-membered imide ring (6-PI) has better chemical resistance than five-membered imide ring (5-PI), but is difficult to be processed into nanofibers due to the poor processability. In...
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Article
Open AccessDownregulation of miR-223 promotes HMGB2 expression and induces oxidative stress to activate JNK and promote autophagy in an in vitro model of acute lung injury
Excessive autophagic activity in alveolar epithelial cells is one of the main causes of acute lung injury (ALI), but the underlying molecular mechanism has not been fully elucidated. Previous studies have show...
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Article
Nomogram for the prediction of primary distant metastasis of nasopharyngeal carcinoma to guide individualized application of FDG PET/CT
This study aimed to establish an effective nomogram to predict primary distant metastasis (DM) in patients with nasopharyngeal carcinoma (NPC) to guide the application of PET/CT.
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Article
Open AccessLow value of whole-body dual-modality [18f]fluorodeoxyglucose positron emission tomography/computed tomography in primary staging of stage I–II nasopharyngeal carcinoma: a nest case-control study
The value of using PET/CT for staging of stage I–II NPC remains unclear. Hence, we aimed to investigate the survival benefit of PET/CT for staging of early-stage NPC before radical therapy.
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Article
Open AccessNovel foetal echocardiographic image processing software (5D Heart) improves the display of key diagnostic elements in foetal echocardiography
To evaluate the clinical value of foetal intelligent navigation echocardiography (5D Heart) for the display of key diagnostic elements in basic sections.
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Chapter and Conference Paper
Prediction of lncRNA-Disease Associations from Heterogeneous Information Network Based on DeepWalk Embedding Model
Long non-coding RNA is a class of non-coding RNAs, with a length of more than 200 nucleotides. A large number of studies have shown that lncRNAs are involved in various life processes of the Human body and pla...
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Article
Open AccessInhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF-κB/AQP8 pathway
Currently, preliminary results have confirmed the existence of receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL)-dependent necroptosis of pancreatic acinar cells...
