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Article
Dahuang Zhechong Pill Alleviates Liver Fibrosis Progression by Regulating p38 MAPK/NF-κ B/TGF-β1 Pathway
To explore the effect and mechanism of Dahuang Zhechong Pill (DHZCP) on liver fibrosis.
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Article
Open AccessA Cysteinyl-tRNA Synthetase Mutation Causes Novel Autosomal-Dominant Inheritance of a Parkinsonism/Spinocerebellar-Ataxia Complex
This study aimed to identify possible pathogenic genes in a 90-member family with a rare combination of multiple neurodegenerative disease phenotypes, which has not been depicted by the known neurodegenerative...
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Article
Open AccessMolecular characterization of Clostridium perfringens isolates from a tertiary children’s hospital in Guangzhou, China, establishing an association between bacterial colonization and food allergies in infants
Cow’s milk protein allergy (CMPA) is one of the most common types of food allergy in infants. Faecal pathogen cultures showed that the positive rate of Clostridium perfringens was more than 30%, which was sign...
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Article
Does the last 20 years paradigm of clinical research using volatile organic compounds to non-invasively diagnose cancer need to change? Challenges and future direction
Volatile organic compounds (VOCs) have shown great potential as novel biomarkers for cancer detection; however, comprehensive quantitative analysis is lacking. In this study, we performed a bibliometric analys...
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Article
Predicting the dietary fiber content of fresh-cut bamboo shoots using a visible and near-infrared hyperspectral technique
The dietary fiber content in fresh-cut bamboo shoots is considered crucial for the quality of processed bamboo shoots products. This study aimed to explore the potential of applying two different hyperspectral...
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Article
Open AccessLysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance
Posttranslational modification dramatically enhances protein complexity, but the function and precise mechanism of novel lysine acylation modifications remain unknown. Chemoresistance remains a daunting challe...
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Article
A phase III randomized, double-blind, placebo-controlled trial of the denosumab biosimilar QL1206 in postmenopausal Chinese women with osteoporosis and high fracture risk
The current study evaluated the efficacy and safety of a denosumab biosimilar, QL1206 (60 mg), compared to placebo in postmenopausal Chinese women with osteoporosis and high fracture risk. At 31 study centers ...
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Article
Open AccessA clinically feasible circulating tumor cell sorting system for monitoring the progression of advanced hepatocellular carcinoma
Hematogenous metastasis is essential for the progression of advanced hepatocellular carcinoma (HCC) and can occur even after patients receive multidisciplinary therapies, including immunotherapy and hepatectom...
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Article
Open AccessExpert consensus on the monitoring and treatment of sepsis-induced immunosuppression
Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice recommendations on the immune function in sepsis, an expert consensus...
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Article
Mucilaginibacter Phenanthrenivorans sp. nov., a Novel Phenanthrene Degradation Bacterium Isolated from Wetland Soil
BJC16-A38T, a Gram-negative, aerobic and non-motile rod-shaped strain was isolated from a permafrost wetland soil sample. BJC16-A38T was oxidase- and catalase-positive, and produced pale yellow colonies on modifi...
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Article
Open AccessShort term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China
With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged...
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Article
Alternate freezing and thawing enhanced the sediment and nutrient runoff loss in the restored soil of the alpine mining area
This study highlights the influence of freezing-thawing processes on soil erosion in an alpine mine restoration area. Accordingly, a series of simulation experiments were conducted to investigate runoff, sedim...
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Article
Open AccessMutation of KIT in cellular extraskeletal myxoid chondrosarcoma: a case report and literature review
Extraskeletal myxoid chondrosarcomas (EMCs) are solid tumors that have been genetically and biologically characterized. Only a few studies have discussed the role of the KIT gene or CD117 expression in EMCs, iden...
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Article
Open AccessEvaluation of efficacy and safety of Qiangzhu-qinggan formula as an adjunctive therapy in adult patients with severe influenza: study protocol for a randomized parallel placebo-controlled double-blind multicenter trial
Influenza can fall into three categories according to severity: mild influenza, severe influenza, and critical influenza. Severe influenza can result in critical illness and sometimes death particularly in pat...
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Article
Open AccessCEBPG promotes acute myeloid leukemia progression by enhancing EIF4EBP1
Acute myeloid leukemia (AML) is a myeloid neoplasm accounts for 7.6% of hematopoietic malignancies. AML is a complex disease, and understanding its pathophysiology is contributing to the improvement in the tre...
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Article
Open AccessA structural deep network embedding model for predicting associations between miRNA and disease based on molecular association network
Previous studies indicated that miRNA plays an important role in human biological processes especially in the field of diseases. However, constrained by biotechnology, only a small part of the miRNA-disease as...
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Article
Ghrelin Affects Gastric Cancer Progression by Activating AMPK Signaling Pathway
As the endogenous ligand for the GH secretagogue receptor (GHSR), Ghrelin is aberrant expressed in multiple malignant carcinoma, and involved in regulating a number of progression of cancer, especially in meta...
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Article
Open AccessPredictive value of aberrant right subclavian artery for fetal chromosome aneuploidy in women of advanced maternal age
In the entire population, an aberrant right subclavian artery (ARSA) is closely associated with chromosomal abnormalities. ARSA with additional ultrasonic findings would increase risk of chromosomal abnormalit...
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Chapter and Conference Paper
An Efficient Adaptive Fault Diagnosis Algorithm for Highly Scalable Data Center Networks
The big data system based on data center network provides low-latency, high-quality services for big data applications. When server failure occurs in data center network, the security of the big data platform ...
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Article
Open AccessVagus nerve stimulation optimized cardiomyocyte phenotype, sarcomere organization and energy metabolism in infarcted heart through FoxO3A-VEGF signaling
Vagus nerve stimulation (VNS) restores autonomic balance, suppresses inflammation action and minimizes cardiomyocyte injury. However, little knowledge is known about the VNS’ role in cardiomyocyte phenotype, s...
