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Article
Nanodiamond: a promising metal-free nanoscale material in photocatalysis and electrocatalysis
Benefiting from its surface-rich functional groups, eco-friendliness, impressive electrochemical properties, excellent light absorption, structural tunability at the atomic/morphological level, and ultra-high ...
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Article
Elimination of cracks in stainless steel casings via 3D printed sand molds with an internal topology structure
The important supporting component in a gas turbine is the casing, which has the characteristics of large size, complex structure, and thin wall. In the context of existing 3DP sand casting processes, casting ...
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Article
Construction of iron oxyhydroxide/nickel sulfate hydroxide hybrid electrocatalyst for efficient oxygen evolution
Transition metal (TM) basic salts have been recognized as high-efficiency catalysts for electrocatalytic oxygen evolution reaction (OER), which is of great importance for producing clean hydrogen energy. Herei...
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Article
Copper-catalyzed enantioselective desymmetrizing C(sp2)–H functionalization of azide-ynamides via α-imino copper carbenes
α-Imino metal carbenes are versatile intermediates in organic synthesis, and have broad applications in the assembly of divergent N-heterocycles. However, the catalytic enantioselective desymmetrization based on
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Article
Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Article
Genotypic richness affects inorganic N uptake and N form preference of a clonal plant via altering soil N pools
Similar to species richness, genotypic richness of plants plays a pivotal role in the structure and function of ecosystems. While the contribution of intraspecific variability to ecosystem function has been we...
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Article
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Article
Open AccessExploring plant-derived phytochrome chaperone proteins for light-switchable transcriptional regulation in mammals
Synthetic biology applications require finely tuned gene expression, often mediated by synthetic transcription factors (sTFs) compatible with the human genome and transcriptional regulation mechanisms. While v...
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Article
Environmental Enrichment Improves the Recognition Memory in Adult Mice Following Social Isolation via Downregulation of Kv4.2 Potassium Channels
Recognition memory is a cognitive process that enables us to distinguish familiar objects and situations from new items, which is essential for mammalian survival and adaptation to a changing environment. Soci...
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Article
Open AccessAc2-26 reduced the liver injury after cardiopulmonary bypass in rats via AKT1/GSK3β/eNOS pathway
About 10% of patients after cardiopulmonary bypass (CPB) would undergo acute liver injury, which aggravated the mortality of patients. Ac2-26 has been demonstrated to ameliorate organic injury by inhibiting in...
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Article
Open AccessAc2-26 activated the AKT1/GSK3β pathway to reduce cerebral neurons pyroptosis and improve cerebral function in rats after cardiopulmonary bypass
Cardiopulmonary bypass (CPB) results in brain injury, which is primarily caused by inflammation. Ac2-26 protects against ischemic or hemorrhage brain injury. The present study was to explore the effect and mec...
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Article
A Galerkin meshless framework for static and vibration analysis of magneto-electro-elastic structures in hygrothermal environment
The work performance of smart structures is easily affected by external environmental factors. A Galerkin meshless method, multi-physics zonal Galerkin free element method (MZG-FREM), is proposed for construct...
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Article
Structural Evolution of Ultra-High Molecular Weight Polyethylene Low-Entangled Films with Reserved Shish Crystals During Hot Stretching
Shish crystals are crucial to achieving high performance low-dimensional ultra-high molecular weight polyethylene (UHMWPE) products. Typically, high stretch and shear flow fields are necessary for the formatio...
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Article
Distinct roles of excitatory and inhibitory neurons in the medial prefrontal cortex in the expression and reconsolidation of methamphetamine-associated memory in male mice
Methamphetamine, a commonly abused drug, is known for its high relapse rate. The persistence of addictive memories associated with methamphetamine poses a significant challenge in preventing relapse. Memory re...
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Article
Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E2 in the lateral parabrachial nucleus of male rats
It has been shown that prostaglandin (PG) E2 synthesized in the lateral parabrachial nucleus (LPBN) is involved in lipopolysaccharide-induced fever. But the neural mechanisms of how intra-LPBN PGE2 induces fever ...
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Article
Brain endothelial GSDMD activation mediates inflammatory BBB breakdown
The blood–brain barrier (BBB) protects the central nervous system from infections or harmful substances1; its impairment can lead to or exacerbate various diseases of the central nervous system2–4. However, the m...
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Article
Comparative efficacy of alkaline slag, biomass ash, and biochar application for the amelioration of different acidic soils
This study aimed at comparing the multi-functions of by-product amendments for ameliorating acidic soils, namely, liming effect, aluminum immobilization and fertility improvement.
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Article
Open AccessSTING-dependent trained immunity contributes to host defense against Clostridium perfringens infection via mTOR signaling
Clostridium perfringens (C. perfringens) infection is recognized as one of the most challenging issues threatening food safety and perplexing agricultural development. To date, the molecular mechanisms of the int...
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Article
Open AccessDownregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its role in hepatocellular carcinoma (HCC) is unknown.
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Article
Element differential method for contact problems with non-conforming contact discretization
In this paper, a new strong-form numerical method, the element differential method (EDM) is employed to solve two- and three-dimensional contact problems without friction. When using EDM, one can obtain the sy...
