30 Result(s)

Article

The functional motif of SARS-CoV S protein involved in the interaction with ACE2

SARS-CoV is a newly discovery pathogen causing severe acute respiratory problems. It has been established that the S protein in this pathogen plays an important rule in the adsorption and penetration of SARS-C...

Yi Zhang, Wei Wang, **-rong Gao, Li Ye, **ao-nan Fang, Ying-chun Zeng… in Virologica Sinica (2007)

Article

Association between VDR and ESR1 gene polymorphisms with bone and obesity phenotypes in Chinese male nuclear families

The goal of this study was to determine whether polymorphisms in the vitamin D receptor (VDR) and estrogen receptor alpha (ESR1) genes are associated with variations of peak bone mineral density (BMD) and obesity...

Jie-mei Gu, Wen-** **ao, **-wei He, Hao Zhang, Wei-wei Hu… in Acta Pharmacologica Sinica (2009)

Article

Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc

Oridonin, a tetracycline diterpenoid compound, has the potential antitumor activities. Here, we evaluate the antitumor activity and action mechanisms of oridonin in colorectal cancer.

Feng-Hou Gao, **ao-Hui Hu, Wei Li, Hua Liu, Yan-Jie Zhang, Zhu-Ying Guo… in BMC Cancer (2010)

Article

Continuous and low-energy ¹²⁵I seed irradiation changes DNA methyltransferases expression patterns and inhibits pancreatic cancer tumor growth

Iodine 125 (¹²⁵I) seed irradiation is an effective treatment for unresectable pancreatic cancers. However, the radiobiological mechanisms underlying brachytherapy remain unclear. Therefore, we investigated the in...

Jian-xia Ma, Zhen-dong **, Pei-ren Si… in Journal of Experimental & Clinical Cancer … (2011)

Article

A 5'-proximal Stem-loop Structure of 5' Untranslated Region of Porcine Reproductive and Respiratory Syndrome Virus Genome Is Key for Virus Replication

It has been well documented that the 5' untranslated region (5' UTR) of many positive-stranded RNA viruses contain key cis-acting regulatory sequences, as well as high-order structural elements. Little is known f...

Jiaqi Lu, Fei Gao, Zuzhang Wei, ** Liu, Changlong Liu, Haihong Zheng… in Virology Journal (2011)

Article

Characterization of Quin-C1 for its anti-inflammatory property in a mouse model of bleomycin-induced lung injury

To study the in vivo effects of Quin-C1, a highly specific agonist for formyl peptide receptor 2 (FPR2/ALX), in a mouse model of bleomycin (BLM)-induced lung injury.

Min He, Ni Cheng, Wei-wei Gao, Meng Zhang, Yue-yun Zhang… in Acta Pharmacologica Sinica (2011)

Article

Association of ALOX15 gene polymorphisms with obesity-related phenotypes in Chinese nuclear families with male offspring

Genetic variation in ALOX12, which encoded human 12-lipoxygenase, was found to be associated with fat mass in young Chinese men. The objective of this study was to investigate the relationship between single n...

Yao-hua Ke, Wen-** **ao, **-wei He, Hao Zhang, **-bo Yu… in Acta Pharmacologica Sinica (2012)

Article

Interferon-α enhances antitumor activities of oncolytic adenovirus-mediated IL-24 expression in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) has a dismal 5-year-survival rate of 10%, so novel strategies are warranted. IL-24 mediates anti-tumor activity reducing STAT3 expression, which suggests that interferon (IFN) al...

Cong-Jun Wang, Chao-Wen **ao, Tian-Geng You, Ya-**n Zheng, Wei Gao… in Molecular Cancer (2012)

Article

Combination of olfactory test and substantia nigra transcranial sonopraphy in the differential diagnosis of Parkinson’s disease: a pilot study from China

Both hyposmia and substania nigra (SN) hyperechogenicity on trascranial sonography (TCS) were risk markers for idiopathic Parkinson’s disease (PD), which was beneficial to the differential diagnosis of the dis...

Wei Chen, Yu-Yan Tan, Yun-Yun Hu, Wei-Wei Zhan, Li Wu… in Translational Neurodegeneration (2012)

Article

Protective effect of Zhuyeqing liquor, a Chinese traditional health liquor, on acute alcohol-induced liver injury in mice

The study first evaluated the hepatoprotective effect of Zhuyeqing Liquor (ZYQL) against acute alcohol-induced liver injury in mice. Animals were administered orally with 50% alcohol 12 ml/kg at 4 h after the ...

Hong-ying Gao, Jian Huang, Hang-yu Wang, **ao-wei Du… in Journal of Inflammation (2013)

Article

Sirt1 is involved in decreased bone formation in aged apolipoprotein E-deficient mice

Apolipoprotein E (ApoE) plays an important role in the transport and metabolism of lipids. Recent studies show that bone mass is increased in young apoE^−/− mice. In this study we investigated the bone phenotype a...

Wei Hong, **ao-ya Xu, Zhao-hui Qiu, Jian-jun Gao… in Acta Pharmacologica Sinica (2015)

Article

Social Isolation During Adolescence Strengthens Retention of Fear Memories and Facilitates Induction of Late-Phase Long-Term Potentiation

Social isolation during the vulnerable period of adolescence produces emotional dysregulation that often manifests as abnormal behavior in adulthood. The enduring consequence of isolation might be caused by a ...

Ji-Hong Liu, Qiang-Long You, Mei-Dan Wei, Qian Wang, Zheng-Yi Luo… in Molecular Neurobiology (2015)

Article

Novel germline mutations and unclassified variants of BRCA1 and BRCA2 genes in Chinese women with familial breast/ovarian cancer

Germline mutations in the BRCA1 and BRCA2 genes greatly increase a woman’s risk of develo** breast and/or ovarian cancer. The prevalence and distribution of such mutations differ across races/ethnicities. Sever...

Wen-Ming Cao, Yun Gao, Hong-Jian Yang, Shang-Nao **e, **ao-Wen Ding… in BMC Cancer (2016)

Article

Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCε-dependent activation of TRPV1

Severe painful sensory neuropathy often occurs during paclitaxel chemotherapy. Since paclitaxel can activate mast cell and basophils, whereas quercetin, a polyphenolic flavonoid contained in various plants, wh...

Wei Gao, Yan Zan, Zai-jie Jim Wang, **ao-yu Hu, Fang Huang in Acta Pharmacologica Sinica (2016)

Article

The role of adenosinergic pathway in human autoimmune diseases

Autoimmune diseases are characterized by the abnormal immune response against self-tissue, which are caused by the failure of nature immune homeostasis. Nature immune homeostasis represents the normal state o...

Ke Dong, Zhao-wei Gao, Hui-zhong Zhang in Immunologic Research (2016)

Article

CD73 promotes proliferation and migration of human cervical cancer cells independent of its enzyme activity

CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, CD73 plays its enzymatic function by catalyzing the hydrolysis of AMP into adenosine and phosphate. In addition to this, accumul...

Zhao-wei Gao, Hui-** Wang, Fang Lin, ** Wang, Min Long, Hui-zhong Zhang… in BMC Cancer (2017)

Article

Abstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC)

Nantanit Sutthiruk, Mari Botti… in Antimicrobial Resistance & Infection Contr… (2017)

Article

Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Nat. Med. 23, 703–713 (2017); published online 08 May 2017; corrected after print 14 June 2017 In the version of this article initially published online, the top value in the y axis of the Kaplan–Meier plots i...

Ahmet Zehir, Ryma Benayed, Ronak H Shah, Aijazuddin Syed, Sumit Middha… in Nature Medicine (2017)

Article

Protectin DX increases alveolar fluid clearance in rats with lipopolysaccharide-induced acute lung injury

Acute respiratory distress syndrome is a life-threatening critical syndrome resulting largely from the accumulation of and the inability to clear pulmonary edema. Protectin DX, an endogenously produced lipid m...

**ao-Jun Zhuo, Yu Hao, Fei Cao, Song-Fan Yan, Hui Li… in Experimental & Molecular Medicine (2018)

Article

A selective c-Met and Trks inhibitor Indo5 suppresses hepatocellular carcinoma growth

Human hepatocellular carcinoma (HCC) lacks effective curative therapy and there is an urgent need to develop a novel molecular-targeted therapy for HCC. Selective tyrosine kinase inhibitors have shown promise ...

Teng Luo, Shou-Guo Zhang, Ling-Fei Zhu… in Journal of Experimental & Clinical Cancer … (2019)