30 Result(s)

Article

Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration

GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its role in hepatocellular carcinoma (HCC) is unknown.

Chen-Yang Tao, **ao-Ling Wu, Shu-Shu Song, Zheng Tang, Yu-Fu Zhou… in Cellular Oncology (2024)

Article

Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis

Demyelination and failure of remyelination in the central nervous system (CNS) characterize a number of neurological disorders. Spontaneous remyelination in demyelinating diseases is limited, as oligodendrocyt...

**ao-Yu Ji, Yu-**n Guo, Li-Bin Wang, Wen-Cheng Wu… in Journal of Neuroinflammation (2024)

Article

Prolyl endopeptidase remodels macrophage function as a novel transcriptional coregulator and inhibits fibrosis

Macrophages are immune cells crucial for host defense and homeostasis maintenance, and their dysregulation is involved in multiple pathological conditions, such as liver fibrosis. The transcriptional regulatio...

Shuang-Zhe Lin, Wei-Jie Wu, Yu-Qing Cheng… in Experimental & Molecular Medicine (2023)

Article

CpG-binding protein CFP1 promotes ovarian cancer cell proliferation by regulating BST2 transcription

Epigenetic alterations have been functionally linked to ovarian cancer development and occurrence. The CXXC zinc finger protein 1 (CFP1) is an epigenetic regulator involved in DNA methylation and histone modif...

Liu-Qing Yang, Han-Yin Hu, Yao Han, Ze-Yi Tang, Jie Gao, Qi-Yin Zhou… in Cancer Gene Therapy (2022)

Article

Prenatal inflammation exposure-programmed hypertension exhibits multi-generational inheritance via disrupting DNA methylome

The multi-generation heredity trait of hypertension in human has been reported, but the molecular mechanisms underlying multi-generational inheritance of hypertension remain obscure. Recent evidence shows that...

**ao Guan, Guo-rong Dan, Yao Yang, Yan Ji, Wen-**g Lai… in Acta Pharmacologica Sinica (2022)

Article

Interleukin 13 promotes long-term recovery after ischemic stroke by inhibiting the activation of STAT3

Microglia/macrophages are activated after cerebral ischemic stroke and can contribute to either brain injury or recovery by polarizing microglia/macrophage into distinctive functional phenotypes with pro- or a...

Di Chen, Jiaying Li, Yichen Huang, Pengju Wei, Wanying Miao… in Journal of Neuroinflammation (2022)

Article

Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients

Human infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and there is no cure currently. The 3CL protease (3CLpro) is a highly conserved prot...

Hai-xia Su, Sheng Yao, Wen-feng Zhao, Min-jun Li, Jia Liu… in Acta Pharmacologica Sinica (2020)

Article

Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injury

Aucubin (Au), an iridoid glycoside from natural plants, has antioxidative and anti-inflammatory bioactivities; however, its effects on a traumatic brain injury (TBI) model remain unknown. We explored the poten...

Han Wang, **ao-Ming Zhou, Ling-Yun Wu, Guang-Jie Liu… in Journal of Neuroinflammation (2020)

Article

Serum miR-101-3p combined with pepsinogen contributes to the early diagnosis of gastric cancer

This study aimed to explore the diagnostic value of serum miR-101-3p combined with pepsinogen (PG) on early diagnosis of gastric cancer (GC).

Weiwei Zeng, Shuxiang Zhang, Lei Yang, Wenchao Wei, Jie Gao, Ni Guo… in BMC Medical Genetics (2020)

Article

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, whic...

Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca… in npj Breast Cancer (2019)

Article

A selective c-Met and Trks inhibitor Indo5 suppresses hepatocellular carcinoma growth

Human hepatocellular carcinoma (HCC) lacks effective curative therapy and there is an urgent need to develop a novel molecular-targeted therapy for HCC. Selective tyrosine kinase inhibitors have shown promise ...

Teng Luo, Shou-Guo Zhang, Ling-Fei Zhu… in Journal of Experimental & Clinical Cancer … (2019)

Article

Protectin DX increases alveolar fluid clearance in rats with lipopolysaccharide-induced acute lung injury

Acute respiratory distress syndrome is a life-threatening critical syndrome resulting largely from the accumulation of and the inability to clear pulmonary edema. Protectin DX, an endogenously produced lipid m...

**ao-Jun Zhuo, Yu Hao, Fei Cao, Song-Fan Yan, Hui Li… in Experimental & Molecular Medicine (2018)

Article

Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Nat. Med. 23, 703–713 (2017); published online 08 May 2017; corrected after print 14 June 2017 In the version of this article initially published online, the top value in the y axis of the Kaplan–Meier plots i...

Ahmet Zehir, Ryma Benayed, Ronak H Shah, Aijazuddin Syed, Sumit Middha… in Nature Medicine (2017)

Article

Abstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC)

Nantanit Sutthiruk, Mari Botti… in Antimicrobial Resistance & Infection Contr… (2017)

Article

CD73 promotes proliferation and migration of human cervical cancer cells independent of its enzyme activity

CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, CD73 plays its enzymatic function by catalyzing the hydrolysis of AMP into adenosine and phosphate. In addition to this, accumul...

Zhao-wei Gao, Hui-** Wang, Fang Lin, ** Wang, Min Long, Hui-zhong Zhang… in BMC Cancer (2017)

Article

The role of adenosinergic pathway in human autoimmune diseases

Autoimmune diseases are characterized by the abnormal immune response against self-tissue, which are caused by the failure of nature immune homeostasis. Nature immune homeostasis represents the normal state o...

Ke Dong, Zhao-wei Gao, Hui-zhong Zhang in Immunologic Research (2016)

Article

Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCε-dependent activation of TRPV1

Severe painful sensory neuropathy often occurs during paclitaxel chemotherapy. Since paclitaxel can activate mast cell and basophils, whereas quercetin, a polyphenolic flavonoid contained in various plants, wh...

Wei Gao, Yan Zan, Zai-jie Jim Wang, **ao-yu Hu, Fang Huang in Acta Pharmacologica Sinica (2016)

Article

Novel germline mutations and unclassified variants of BRCA1 and BRCA2 genes in Chinese women with familial breast/ovarian cancer

Germline mutations in the BRCA1 and BRCA2 genes greatly increase a woman’s risk of develo** breast and/or ovarian cancer. The prevalence and distribution of such mutations differ across races/ethnicities. Sever...

Wen-Ming Cao, Yun Gao, Hong-Jian Yang, Shang-Nao **e, **ao-Wen Ding… in BMC Cancer (2016)

Article

Sirt1 is involved in decreased bone formation in aged apolipoprotein E-deficient mice

Apolipoprotein E (ApoE) plays an important role in the transport and metabolism of lipids. Recent studies show that bone mass is increased in young apoE^−/− mice. In this study we investigated the bone phenotype a...

Wei Hong, **ao-ya Xu, Zhao-hui Qiu, Jian-jun Gao… in Acta Pharmacologica Sinica (2015)

Article

Social Isolation During Adolescence Strengthens Retention of Fear Memories and Facilitates Induction of Late-Phase Long-Term Potentiation

Social isolation during the vulnerable period of adolescence produces emotional dysregulation that often manifests as abnormal behavior in adulthood. The enduring consequence of isolation might be caused by a ...

Ji-Hong Liu, Qiang-Long You, Mei-Dan Wei, Qian Wang, Zheng-Yi Luo… in Molecular Neurobiology (2015)