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  1. Article

    Open Access

    Synthetic macrolides overcoming MLSBK-resistant pathogens

    Conventional macrolide-lincosamide-streptogramin B-ketolide (MLSBK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...

    Cong-Xuan Ma, Ye Li, Wen-Tian Liu, Yun Li, Fei Zhao, **ao-Tian Lian in Cell Discovery (2024)

  2. Article

    Open Access

    The effect of hyperlipidemia on overall survival in patients with cancer was differentiated by BMI and hyperlipidemia type

    The impact of lipids on the overall survival (OS) of patients with malignancy has not yet been clarified. This study aimed to evaluate the effect of hyperlipidemia on the OS among Chinese patients based on Bod...

    Hai-Ying Tian, Ming Yang, Hai-Lun **e, Guo-Tian Ruan, Yi-Zhong Ge in Nutrition & Metabolism (2024)

  3. Article

    Open Access

    Wnt5a-mediated autophagy contributes to the epithelial-mesenchymal transition of human bronchial epithelial cells during asthma

    The epithelial-mesenchymal transition (EMT) of human bronchial epithelial cells (HBECs) is essential for airway remodeling during asthma. Wnt5a has been implicated in various lung diseases, while its role in t...

    Yu-Biao Liu, **ao-Hua Tan, Hui-Hui Yang, **-Tong Yang, Chen-Yu Zhang in Molecular Medicine (2024)

  4. No Access

    Article

    Liver receptor homolog-1: structures, related diseases, and drug discovery

    Liver receptor homolog-1 (LRH-1), a member of the nuclear receptor superfamily, is a ligand-regulated transcription factor that plays crucial roles in metabolism, development, and immunity. Despite being class...

    Tong Wu, Zhi-fang Lu, Hao-nan Yu, **-shan Wu, Yang Liu in Acta Pharmacologica Sinica (2024)

  5. No Access

    Article

    Fetal overgrowth and weight trajectories during infancy and adiposity in early childhood

    Large-for-gestational age (LGA), a marker of fetal overgrowth, has been linked to obesity in adulthood. Little is known about how infancy growth trajectories affect adiposity in early childhood in LGA.

    Min-Yi Tao, **n Liu, Zi-Lin Chen, Meng-Nan Yang, Ya-Jie Xu, Hua He in Pediatric Research (2024)

  6. Article

    Open Access

    Pancreatitis affects gut microbiota via metabolites and inflammatory cytokines: an exploratory two-step Mendelian randomisation study

    Previous studies have observed relationships between pancreatitis and gut microbiota; however, specific changes in gut microbiota abundance and underlying mechanisms in pancreatitis remain unknown. Metabolites...

    Yi-Fan Qiu, Jun Ye, **-** **e, **ao-Tong Mao in Molecular Genetics and Genomics (2024)

  7. Article

    Open Access

    PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells

    Maintaining genomic stability is a prerequisite for proliferating NPCs to ensure genetic fidelity. Though histone arginine methylation has been shown to play important roles in safeguarding genomic stability, ...

    Ya-Jun Wang, Jian-Bo Cao, **g Yang, Tong Liu in Cellular and Molecular Life Sciences (2024)

  8. Article

    Open Access

    Global fungal-host interactome map** identifies host targets of candidalysin

    Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we perfo...

    Tian-Yi Zhang, Yao-Qi Chen, **g-Cong Tan, **-An Zhou in Nature Communications (2024)

  9. Article

    Open Access

    Microbes translocation from oral cavity to nasopharyngeal carcinoma in patients

    The presence of oral microbes in extra-oral sites is linked to gastrointestinal cancers. However, their potential ectopically colonization in the nasopharynx and impact on local cancer development remains unce...

    Ying Liao, Yan-**a Wu, Minzhong Tang, Yi-Wei Chen, **-Ru **e in Nature Communications (2024)

  10. No Access

    Article

    Potential protective effects of sodium butyrate on glycinin-induced oxidative stress, inflammatory response, and growth inhibition in Cyprinus carpio

    Investigated mitigating effects of sodium butyrate (SB) on the inflammatory response, oxidative stress, and growth inhibition of common carp (Cyprinus carpio) (2.94 ± 0.2 g) are caused by glycinin. Six isonitroge...

    Deng-Lai Li, Si-Ying Liu, Rui Zhu, Si-Tong Meng in Fish Physiology and Biochemistry (2024)

  11. No Access

    Article

    High critical current density in Li6.4La3Zr1.4Ta0.6O12 electrolyte via interfacial engineering with complex hydride

    Garnet-type solid-state batteries (SSBs) are considered to be one of the most promising candidates to realize next-generation lithium metal batteries with high energy density and safety. However, the dendrite-...

    Ying-Tong Lv, Teng-Fei Zhang, Zhao-Tong Hu, Guang-Lin **a, Ze-Ya Huang in Rare Metals (2024)

  12. Article

    Open Access

    Engineering metal-carbide hydrogen traps in steels

    Hydrogen embrittlement reduces the durability of the structural steels required for the hydrogen economy. Understanding how hydrogen interacts with the materials plays a crucial role in managing the embrittlem...

    Pang-Yu Liu, Boning Zhang, Ranming Niu, Shao-Lun Lu, Chao Huang in Nature Communications (2024)

  13. Article

    Open Access

    A systematic two-sample and bidirectional MR process highlights a unidirectional genetic causal effect of allergic diseases on COVID-19 infection/severity

    Allergic diseases (ADs) such as asthma are presumed risk factors for COVID-19 infection. However, recent observational studies suggest that the assumed correlation contradicts each other. We therefore systemat...

    **ao-tong Chen, Shuai Zhi, **n-yu Han, Jian-wei Jiang in Journal of Translational Medicine (2024)

  14. Article

    Open Access

    Increased Asian aerosols drive a slowdown of Atlantic Meridional Overturning Circulation

    Observational evidence and climate model experiments suggest a slowdown of the Atlantic Meridional Overturning Circulation (AMOC) since the mid-1990s. Increased greenhouse gases and the declined anthropogenic ...

    Fukai Liu, Xun Li, Yiyong Luo, Wenju Cai, Jian Lu, **ao-Tong Zheng in Nature Communications (2024)

  15. No Access

    Book and Conference Proceedings

    12th Asian-Pacific Conference on Medical and Biological Engineering

    Proceedings of APCMBE 2023, May 18–21, 2023, Suzhou, China—Volume 1: Biomedical Signal Processing, Imaging and Rehabilitation Engineering

    Guangzhi Wang, Dezhong Yao, Zhongze Gu in IFMBE Proceedings (2024)

  16. No Access

    Book and Conference Proceedings

    Computer Supported Cooperative Work and Social Computing

    18th CCF Conference, ChineseCSCW 2023, Harbin, China, August 18–20, 2023, Revised Selected Papers, Part I

    Yuqing Sun, Tun Lu, Tong Wang in Communications in Computer and Information Science (2024)

  17. No Access

    Book and Conference Proceedings

    Computer Supported Cooperative Work and Social Computing

    18th CCF Conference, ChineseCSCW 2023, Harbin, China, August 18–20, 2023, Revised Selected Papers, Part II

    Yuqing Sun, Tun Lu, Tong Wang in Communications in Computer and Information Science (2024)

  18. No Access

    Chapter and Conference Paper

    Research on the Application of Sidetracking Technology to Recover Residual Oil from Old Wells in Shallow and High-Water-Cut Oil Reservoirs in Nanpu Onshore Oilfield

    The shallow land oil reservoir in Nanpu has entered a high water-cut stage, facing difficulties such as dispersed remaining oil, low CO2 flooding recovery efficiency, high proportion of low and ineffective wells,...

    **ao-tong Liu, Ling-ling Xuan, Qiang Liu in Proceedings of the International Field Exp… (2024)

  19. Article

    Open Access

    Elevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma

    Dysregulation of wild-type p53 turnover is a key cause of hepatocellular carcinoma (HCC), yet its mechanism remains poorly understood. Here, we report that WD repeat and SOCS box containing protein 2 (WSB2), a...

    Xun Li, Cheng-Cheng Zhang, **ao-Tong Lin, Jie Zhang in Experimental & Molecular Medicine (2024)

  20. No Access

    Chapter and Conference Paper

    Research Progress on Enhanced Oil Recovery by CO2 Flooding in Low Permeability Reservoirs

    Summarized the current development situation of low permeability oil reservoirs at home and abroad, and sorted out the development process of three stages: indoor research, pilot testing, and field application...

    Wei Zhou, Meng-yao Niu, Wan-**g Luo in Proceedings of the International Field Exp… (2024)

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