-
Article
Lax pair, conservation laws, breather-to-soliton transitions and modulation instability for a coupled extended modified Korteweg-de Vries system in a fluid
The modified Korteweg-de Vries-type equations can be used to describe the interfacial waves in a fluid, elastic quasi-plane waves in a lattice, and Alfvén waves in a collisionless plasma. In this paper, we inv...
-
Article
Open AccessThe m6A reader HNRNPC promotes glioma progression by enhancing the stability of IRAK1 mRNA through the MAPK pathway
Glioma is the most common and aggressive type of primary malignant brain tumor. The N6-methyladenosine (m6A) modification widely exists in eukaryotic cells and plays an important role in the occurrence and dev...
-
Article
Open AccessAstrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice
Epigenetic mechanisms bridge genetic and environmental factors that contribute to the pathogenesis of major depression disorder (MDD). However, the cellular specificity and sensitivity of environmental stress ...
-
Article
Open AccessPrecise planning based on 3D-printed dry-laboratory models can reduce perioperative complications of laparoscopic surgery for complex hepatobiliary diseases: a preoperative cohort study
Complications after laparoscopic liver resection (LLR) are important factors affecting the prognosis of patients, especially for complex hepatobiliary diseases. The present study aimed to evaluate the value of...
-
Article
Development of SV2A Ligands for Epilepsy Treatment: A Review of Levetiracetam, Brivaracetam, and Padsevonil
Epilepsy is a common neurological disorder that is primarily treated with antiseizure medications (ASMs). Although dozens of ASMs are available in the clinic, approximately 30% of epileptic patients have medic...
-
Article
Similarity Reductions on a (2 \(+\) 1)-Dimensional Variable-Coefficient Modified Kadomtsev-Petviashvili System Describing Certain Electromagnetic Waves in a Thin Film
For the electromagnetic waves in an isotropic charge-free infinite thin film with the potential application in magneto-optic recording, we investigate a (2 ...
-
Article
Open AccessA new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers
Trophoblast cell surface antigen 2 (Trop2) is considered to be an attractive therapeutic target in cancer treatments. We previously generated a new humanized anti-Trop2 antibody named hIMB1636, and designated ...
-
Article
Open AccessDownregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
GPX8, which is found in the endoplasmic reticulum lumen, is a member of the Glutathione Peroxidases (GPXs) family. Its role in hepatocellular carcinoma (HCC) is unknown.
-
Article
Open AccessVineyard microclimate alterations induced by black inter-row mulch through transcriptome reshaped the flavoromics of cabernet sauvignon grapes
Weed control is essential for agricultural floor management in vineyards and the inter-row mulching is an eco-friendly practice to inhibit weed growth via filtering out photosynthetically active radiation. Bes...
-
Article
Regulating ion transport behaviors toward dendrite-free potassium metal batteries: recent advances and perspectives
With abundant potassium resources and high capacity, potassium metal batteries (PMBs) present a compelling option for the next generation of energy storage technology. However, PMBs suffer from an unstable ano...
-
Article
Relationship between subtype-specific minimal residual disease level and long-term prognosis in children with acute lymphoblastic leukemia
Minimal residual disease (MRD) based risk stratification criteria for specific genetic subtypes remained unclear in childhood acute lymphoblastic leukemia (ALL). Among 723 children with newly diagnosed ALL tre...
-
Article
Bilinear Bäcklund Transformation, Fission/Fusion and Periodic Waves of a (3+1)-dimensional Kadomtsev-Petviashvili Equation for the Shallow Water Waves
Kadomtsev-Petviashvili (KP)-typed models are used to elucidate certain shallow water waves that arise in plasma physics, marine engineering, ocean physics, fluid dynamics, etc. In this paper, we investigate a ...
-
Article
Study of aerodynamic characteristics of a high-speed train with wings moving through a tunnel
A high-speed train with wings (HSTW) is a new type of train that enhances aerodynamic lift by adding wings, effectively reducing gravity, to reduce the wear and tear of wheels and rails. This study, based on t...
-
Article
Exosomes from Hypoxia-treated Mesenchymal Stem Cells: Promoting Neuroprotection in Ischemic Stroke Through miR-214-3p/PTEN Mechanism
Stroke stands as the second leading cause of death globally, surpassed only by ischemic heart disease. It accounts for 9% of total worldwide deaths. Given the swiftly evolving landscape, medical professionals ...
-
Article
Open AccessDeep learning model based on multi-lesion and time series CT images for predicting the benefits from anti-HER2 targeted therapy in stage IV gastric cancer
To develop and validate a deep learning model based on multi-lesion and time series CT images in predicting overall survival (OS) in patients with stage IV gastric cancer (GC) receiving anti-HER2 targeted ther...
-
Article
Open AccessA landscape of gene expression regulation for synovium in arthritis
The synovium is an important component of any synovial joint and is the major target tissue of inflammatory arthritis. However, the multi-omics landscape of synovium required for functional inference is absent...
-
Article
Open AccessRisk factors associated with severe adverse events in patients with relapsing polychondritis undergoing flexible bronchoscopy
Patients with relapsing polychondritis (RP) sometimes experience upper airway collapse or lower airway stenosis, and bronchoscopy may provide a valuable typical image to confirm the diagnosis. This study aimed...
-
Article
Open AccessMolecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy
Procaspase 9 is the initiator caspase for apoptosis, but how its levels and activities are maintained remains unclear. The gigantic Inhibitor-of-Apoptosis Protein BIRC6/BRUCE/Apollon inhibits both apoptosis an...
-
Article
Travelling-wave, Mixed-lump-kink and Mixed-rogue-wave-kink Solutions for an Extended (3+1)-dimensional Shallow Water Wave Equation in Oceanography and Atmospheric Science
Shallow water waves are seen in oceanography, atmospheric science, and other fields. In this paper, we investigate an extended (3+1)-dimensional shallow water wave equation. We get the travelling-wave solution...
-
Chapter and Conference Paper
Study on Influence Factors of Sealing Pipe Thread Connection
With the development of scientific and technological innovation, pipe threads are more and more widely used in industry, especially in the field of hydraulic manifolds. This paper introduces the structure form...
