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Article
Estimating the Mechanical Properties of Rocks and Rock Masses Based on Mineral Micromechanics Testing
Estimation of rock uniaxial compressive strength and elastic modulus from mineral micromehanical properties.
Upscaling tech...
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Article
T cell-redirecting antibody for treatment of solid tumors via targeting mesothelin
T cell engaging bispecific antibodies (TCBs) have recently become significant in cancer treatment. In this study we developed MSLN490, a novel TCB designed to target mesothelin (MSLN), a glycosylphosphatidylin...
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Article
Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior: Synthesis, Characterization and Biological Applications
Non-aromatic fluorescent and multi-responsive materials, exhibiting inherent fluorescence emission and controlled phase change, have garnered significant attention in recent years. However, the underlying inte...
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Article
Open AccessAstrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice
Epigenetic mechanisms bridge genetic and environmental factors that contribute to the pathogenesis of major depression disorder (MDD). However, the cellular specificity and sensitivity of environmental stress ...
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Article
CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/β-catenin signaling pathway
Cardiac fibrosis is a detrimental pathological process, which constitutes the key factor for adverse cardiac structural remodeling leading to heart failure and other critical conditions. Circular RNAs (circRNA...
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Article
A new [SiMo12O40]4−-based metal organic framework: synthesis, structure, photo-/electro-catalytic and absorption properties
The water pollution problems caused by organic dyes, inorganic ions and other pollutants are becoming more and more serious, and the removal of pollutants from wastewater is still a challenge. A polyoxometalat...
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Article
Unconventional Fluorescent and Multi-responsive Polysiloxane: Synthesis, Characterization and Biological Applications
Owing to their high significance in fundamental study and diverse applications, stimuli-responsive and fluorescent polymers, particularly those with cluster-triggered emission (CTE) featured by non-conjugated ...
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Article
Open AccessEffectiveness of WeChat-assisted preoperative education to reduce perioperative anxiety in breast cancer patients: a prospective randomized controlled study protocol
Breast cancer is the most prevalent cancer among women globally, and surgical procedures continue to be the primary treatment. However, over 50% of patients experience preoperative anxiety due to the unknown a...
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Article
Synthesis of foamed geopolymers by substituting fly ash with tailing slurry for the highly efficient removal of heavy metal contaminants: Behavioral and mechanistic studies
This study aimed to synthesize porous geopolymers from tailing slurry, a byproduct of bauxite mining, for use as potential materials for groundwater remediation. The effects of various factors, such as foaming...
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Article
Open AccessVirome diversity shaped by genetic evolution and ecological landscape of Haemaphysalis longicornis
Haemaphysalis longicornis is drawing attentions for its geographic invasion, extending population, and emerging disease threat. However, there are still substantial gaps in our knowledge of viral composition in r...
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Article
Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids
A strong correlation between gut microbes and host health has been observed in numerous gut metagenomic cohort studies. However, the underlying mechanisms governing host–microbe interactions in the gut remain ...
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Article
Deterioration of compressive properties of coal rocks under water and gas coupling
The compressive properties of coal under water-gas coupling were studied based on the water-rock-gas coupling test system. The compressive strength and deformation damage characteristics of the coal samples we...
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Article
Open AccessAddendum: Cellular differentiation into hyphae and spores in halophilic archaea
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Article
Dual-loading strategy to construct Au-BiOBr-TiO2 photocatalysts for fast and efficient degradation of xanthates under visible light
With the advancement of mining operations, xanthate as an essential flotation reagent is unavoidably released into natural water bodies through flotation effluent. To protect the surrounding environment of min...
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Article
Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions
Protein-biomolecule interactions play pivotal roles in almost all biological processes. For a biomolecule of interest, the identification of the interacting protein(s) is essential. For this need, although man...
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Article
Graphical optimization method for bidirectional corridor progression under the signal design mode of split phasing
Using the spatial and temporal characteristics of vehicle movement to analyze the control effect of the corridor progression, we can deeply explore the essential principle of progression design. Based on the p...
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Article
Open AccessEndovascular treatment in bilateral cavernous sinus dural arteriovenous fistulas: a systematic review and meta-analysis
Few studies have discussed the disease nature and treatment outcomes for bilateral cavernous sinus dural arteriovenous fistula (CSDAVF). This study aimed to investigate the clinical features and treatment outc...
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Article
Long-term passaging of pseudo-typed SARS-CoV-2 reveals the breadth of monoclonal and bispecific antibody cocktails
The continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants poses challenges to the effectiveness of neutralizing antibodies. Rational design of antibody cocktails is a re...
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Article
Correlation Analysis of Molecularly-Defined Cortical Interneuron Populations with Morpho-Electric Properties in Layer V of Mouse Neocortex
Cortical interneurons can be categorized into distinct populations based on multiple modalities, including molecular signatures and morpho-electrical (M/E) properties. Recently, many transcriptomic signatures ...
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Article
Open AccessGenome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...
