-
Article
Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
-
Article
Open AccessBiocaiv: an integrative webserver for motif-based clustering analysis and interactive visualization of biological networks
As an important task in bioinformatics, clustering analysis plays a critical role in understanding the functional mechanisms of many complex biological systems, which can be modeled as biological networks. The...
-
Article
Open AccessThe amino acid metabolomics signature of differentiating myocardial infarction from strangulation death in mice models
This study differentiates myocardial infarction (MI) and strangulation death (STR) from the perspective of amino acid metabolism. In this study, MI mice model via subcutaneous injection of isoproterenol and ST...
-
Article
Open AccessMass testing and characterization of 20-inch PMTs for JUNO
Main goal of the JUNO experiment is to determine the neutrino mass ordering using a 20 kt liquid-scintillator detector. Its key feature is an excellent energy resolution of at least 3% at 1 MeV, for which its ...
-
Article
Open AccessRLFDDA: a meta-path based graph representation learning model for drug–disease association prediction
Drug repositioning is a very important task that provides critical information for exploring the potential efficacy of drugs. Yet develo** computational models that can effectively predict drug–disease assoc...
-
Article
Open AccessMulti-view heterogeneous molecular network representation learning for protein–protein interaction prediction
Protein–protein interaction (PPI) plays an important role in regulating cells and signals. Despite the ongoing efforts of the bioassay group, continued incomplete data limits our ability to understand the mole...
-
Article
Open AccessMetagenomic analysis reveals the different characteristics of microbial communities inside and outside the karst tiankeng
Karst tiankengs serve as a reservoir of biodiversity in the degraded karst landscape areas. However, the microbial diversity of karst tiankengs is poorly understood. Here, we investigated the composition and f...
-
Article
Open AccessCircUBE2Q2 promotes differentiation of cattle muscle stem cells and is a potential regulatory molecule of skeletal muscle development
The growth and development of muscle stem cells (MuSCs) are significant events known to affect muscle plasticity, disease, meat production, and meat quality, which involves the types and functions of mRNA and ...
-
Article
Open AccessIn silico drug repositioning using deep learning and comprehensive similarity measures
Drug repositioning, meanings finding new uses for existing drugs, which can accelerate the processing of new drugs research and development. Various computational methods have been presented to predict novel d...
-
Article
Open AccessA comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis
Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiv...
-
Article
Open AccessALDH2 protects against stroke by clearing 4-HNE
Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that metabolizes ethanol and toxic aldehydes such as 4-hydroxy-2-nonenal (4-HNE). Using an unbiased proteomic search, we identified ALDH2 deficiency i...
