-
Article
Open AccessDetection performance of PCR for Legionella pneumophila in environmental samples: a systematic review and meta-analysis
Legionellosis remains a public health problem. The most common diagnostic method to detect Legionella pneumophila (L. pneumophila) is culture. Polymerase chain reaction (PCR) is a fast and accurate method for thi...
-
Article
Open AccessDissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma
Little is known about the transcriptomic plasticity and adaptive mechanisms of circulating tumor cells (CTCs) during hematogeneous dissemination. Here we interrogate the transcriptome of 113 single CTCs from 4...
-
Article
Open AccessRetraction Note: Tumor-specific Th2 responses inhibit growth of CT26 colon-cancer cells in mice via converting intratumor regulatory T cells to Th9 cells
-
Article
Open AccessCorrection to: Risk factors for develo** severe COVID-19 in China: an analysis of disease surveillance data
An amendment to this paper has been published and can be accessed via the original article.
-
Article
Open AccessAuthor Correction: Histone acetyltransferease p300 modulates TIM4 expression in dendritic cells
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessRisk factors for develo** severe COVID-19 in China: an analysis of disease surveillance data
COVID-19 has posed an enormous threat to public health around the world. Some severe and critical cases have bad prognoses and high case fatality rates, unraveling risk factors for severe COVID-19 are of signi...
-
Article
Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin
-
Article
Open AccessNetwork-directed efficient isolation of previously uncultivated Chloroflexi and related bacteria in hot spring microbial mats
The perplexity of the complex multispecies community interactions is one of the many reasons why majority of the microorganisms are still uncultivated. We analyzed the entire co-occurrence networks between the...
-
Article
Open AccessA pneumonia outbreak associated with a new coronavirus of probable bat origin
Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1–4. Previous studi...
-
Article
CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression
Pancreatic adenocarcinoma is a highly malignant cancer that often involves a deregulation of c-Myc. It has been shown that c-Myc plays a pivotal role in the regulation of a variety of physiological processes a...
-
Article
Intelligent diagnosis of jaundice with dynamic uncertain causality graph model
Jaundice is a common and complex clinical symptom potentially occurring in hepatology, general surgery, pediatrics, infectious diseases, gynecology, and obstetrics, and it is fairly difficult to distinguish th...
-
Article
Open AccessVitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis
It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. ...
-
Article
Open AccessInduction of colitis in mice with food allergen-specific immune response
The pathogenesis of intestinal chronic inflammation is unclear. Food allergy plays an important role in the induction of intestinal inflammation. This study aims to test a hypothesis that food allergy initiate...
-
Article
Interleukin-13 interferes with activation-induced t-cell apoptosis by repressing p53 expression
The etiology and the underlying mechanism of CD4+ T-cell polarization are unclear. This study sought to investigate the mechanism by which interleukin (IL)-13 prevents the activation-induced apoptosis of CD4+ T c...
-
Article
Open AccessHistone acetyltransferease p300 modulates TIM4 expression in dendritic cells
TIM4 (T cell immunoglobulin mucin domain molecule-4) plays a critical role in the initiation of skewed T helper (Th) 2 polarization. The factors regulating TIM4 expression are unclear. This study tests a hypot...
-
Article
Open AccessSpecific immunotherapy in combination with Clostridium butyricum inhibits allergic inflammation in the mouse intestine
The current therapy on allergic inflammation is unsatisfactory. Probiotics improve the immunity in the body. This study aims to test a hypothesis that administration with Clostridium butyricum (C. butyricum) enfo...
-
Article
Open AccessRETRACTED ARTICLE: Tumor-specific Th2 responses inhibit growth of CT26 colon-cancer cells in mice via converting intratumor regulatory T cells to Th9 cells
The abnormality of immune regulation plays a critical role in the pathogenesis of cancer; the underlying mechanism has not been fully understood yet. This study aims to investigate the role of cancer specific ...
-
Article
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis
The role of the unfolded protein response (UPR) in tissue homeostasis remains largely unknown. Here we find that loss of Mst1/2, the mammalian Hippo orthologues, or their regulator WW45, leads to a remarkably ...
-
Article
Open AccessTSP1-producing B cells show immune regulatory property and suppress allergy-related mucosal inflammation
Specific immunotherapy (SIT) is the only specific remedy for the treatment of allergic diseases currently. B cells are important immune cells in the immunity. The role of B cells in immune regulatory activitie...
