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6 Result(s)

within **ao-Rong Sun Remove this filter Biomedicine, general Remove this filter Medical Microbiology Remove this filter

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  1. No Access

    Article

    LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles

    Liver fibrosis is a wound-healing process characterized by excess formation of extracellular matrix (ECM) from activated hepatic stellate cells (HSCs). Previous studies show that both EZH2, an epigenetic regul...

    **ao-jiao-yang Li, Fei Zhou, Ya-**g Li, … in Acta Pharmacologica Sinica (2023)

  2. No Access

    Article

    Aurantio-obtusin ameliorates obesity by activating PPARα-dependent mitochondrial thermogenesis in brown adipose tissues

    Obesity contributes to the progression of various chronic diseases, and shortens life expectancy. With abundant mitochondria, brown adipose tissue (BAT) dissipates energy through heat to limit weight gain and ...

    Yi-jie Li, Rui-yu Wu, Run-** Liu, Kai-yi Wu, Ming-ning Ding… in Acta Pharmacologica Sinica (2023)

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    Article

    The baroreflex afferent pathway plays a critical role in H2S-mediated autonomic control of blood pressure regulation under physiological and hypertensive conditions

    Hydrogen sulfide (H2S), which is closely related to various cardiovascular disorders, lowers blood pressure (BP), but whether this action is mediated via the modification of baroreflex afferent function has not b...

    Ying Li, Yan Feng, Li Liu, Xue Li, **n-yu Li, Xun Sun… in Acta Pharmacologica Sinica (2021)

  4. Article

    The protease inhibitor atazanavir blocks hERG K+ channels expressed in HEK293 cells and obstructs hERG protein transport to cell membrane

    Atazanavir (ATV) is a HIV-1 protease inhibitor for the treatment of AIDS patients, which is recently reported to provoke excessive prolongation of the QT interval and torsades de pointes (TdP). In order to elu...

    Sheng-na Han, **ao-yan Sun, Zhao Zhang, Li-rong Zhang in Acta Pharmacologica Sinica (2015)

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  5. Article

    Optimal design and validation of antiviral siRNA for targeting hepatitis B virus

    Optimal design of antiviral short-interfering RNA (siRNA) targeting highly divergent hepatitis B virus (HBV) was validated by quantitative structure-activity relationship (QSAR) analysis.

    Jie Fu, Zhong-ming Tang, **n Gao, Fan Zhao, Hui Zhong… in Acta Pharmacologica Sinica (2008)

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  6. Article

    Effects of coffee and caffeine on bladder dysfunction in streptozotocin-induced diabetic rats

    To explore the effects and mechanisms of caffeine and coffee on bladder dysfunction in streptozotocin-induced diabetic rats.

    Chao-ran Yi, Zhong-qing Wei, **ang-lei Deng, Ze-yu Sun… in Acta Pharmacologica Sinica (2006)

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