5 Result(s)
within
**ao-Rong Jiang
Biomedicine
Immunology
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Article
Melatonin receptor agonist ramelteon attenuates mouse acute and chronic ischemic brain injury
Melatonin receptors (MTs) are potential drug targets for stroke therapy. Ramelteon is a selective melatonin receptor agonist used to treat insomnia. In this study we investigated whether ramelteon could attenu...
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Article
Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors
Aberrant activity of enhancer of zeste homolog 2 (EZH2) is associated with a wide range of human cancers. The interaction of EZH2 with embryonic ectoderm development (EED) is required for EZH2's catalytic acti...
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Article
Toxoplasma gondii infection in the peritoneal macrophages of rats treated with glucocorticoids
It is well known that toxoplasmosis can be life threatening to immunocompromised individuals such as AIDS and organ transplantation patients. Glucocorticoids (GCs) are widely used in the clinic for the treatme...
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Article
LPS pretreatment ameliorates multiple organ injuries and improves survival in a murine model of polymicrobial sepsis
The endotoxin tolerance phenotype is characterized with decreased inflammation and increased phagocytosis. We hypothesized that endotoxin tolerance would provide protective effects on experimental sepsis with ...
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Article
Effects of docosahexaenoic acid on large-conductance Ca2+-activated K+ channels and voltage-dependent K+ channels in rat coronary artery smooth muscle cells
To investigate the effects of docosahexaenoic acid (DHA) on large-conductance Ca2+-activated K+(BKCa) channels and voltage-dependent K+ (KV) channels in rat coronary artery smooth muscle cells (CASMCs).
