40 Result(s)

Article

Astrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice

Epigenetic mechanisms bridge genetic and environmental factors that contribute to the pathogenesis of major depression disorder (MDD). However, the cellular specificity and sensitivity of environmental stress ...

Fang Guo, Jun Fan, **-Ming Liu, Peng-Li Kong, **g Ren… in Nature Communications (2024)

Article

Structural basis and synergism of ATP and Na⁺ activation in bacterial K⁺ uptake system KtrAB

The K⁺ uptake system KtrAB is essential for bacterial survival in low K⁺ environments. The activity of KtrAB is regulated by nucleotides and Na⁺. Previous studies proposed a putative gating mechanism of KtrB regu...

Wesley Tien Chiang, Yao-Kai Chang, Wei-Han Hui, Shu-Wei Chang… in Nature Communications (2024)

Article

The formation of unsaturated IrO_x in SrIrO₃ by cobalt-do** for acidic oxygen evolution reaction

Electrocatalytic water splitting is a promising route for sustainable hydrogen production. However, the high overpotential of the anodic oxygen evolution reaction poses significant challenge. SrIrO₃-based perovsk...

Jia-Wei Zhao, Kaihang Yue, Hong Zhang, Shu-Yin Wei, Jiawei Zhu… in Nature Communications (2024)

Article

Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma

Tumor-secreted factors contribute to the development of a microenvironment that facilitates the escape of cancer cells from immunotherapy. In this study, we conduct a retrospective comparison of the proteins s...

Chunxiao Liu, Chenhao Zhou, Weiya **a, Yifan Zhou, Yufan Qiu… in Nature Communications (2024)

Article

Macro CD5L⁺ deteriorates CD8⁺T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma

Intratumoral immune status influences tumor therapeutic response, but it remains largely unclear how the status determines therapies for patients with intrahepatic cholangiocarcinoma. Here, we examine the sing...

Jia-Cheng Lu, Lei-Lei Wu, Yi-Ning Sun, **ao-Yong Huang, Chao Gao… in Nature Communications (2024)

Article

Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses

Acral melanoma (AM) is a rare subtype of melanoma characterized by a high incidence of lymph node (LN) metastasis, a critical factor in tumor dissemination and therapeutic decision-making. Here, we employ sing...

Chuanyuan Wei, Wei Sun, Kangjie Shen, **gqin Zhong, Wanlin Liu… in Nature Communications (2023)

Article

Subgenome-aware analyses suggest a reticulate allopolyploidization origin in three Papaver genomes

Ren-Gang Zhang, Chaoxia Lu, Guang-Yuan Li, Jie Lv, Longxin Wang… in Nature Communications (2023)

Article

Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype

Immune and inflammatory responses have an important function in the pathophysiology of pulmonary hypertension (PH). However, little is known about the immune landscape in peripheral circulation in patients wit...

**n-Hua Wu, Yang-Yang He, Zhang-Rong Chen, Ze-Yuan He, Yi Yan… in Nature Communications (2023)

Article

A sweat-responsive covalent organic framework film for material-based liveness detection and sweat pore analysis

Covalent organic frameworks have shown considerable application potential and exceptional properties in the construction of stimulus-responsive materials. Here, we designed a sweat-responsive covalent organic ...

Qing Hao, **ao-Rui Ren, Yichen Chen, Chao Zhao, **gyi Xu… in Nature Communications (2023)

Article

A saturated map of common genetic variants associated with human height

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sa...

Loïc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, Eric Bartell… in Nature (2022)

Article

Targeting loop3 of sclerostin preserves its cardiovascular protective action and promotes bone formation

Sclerostin negatively regulates bone formation by antagonizing Wnt signalling. An antibody targeting sclerostin for the treatment of postmenopausal osteoporosis was approved by the U.S. Food and Drug Administr...

Yuanyuan Yu, Luyao Wang, Shuaijian Ni, Dijie Li, ** Liu… in Nature Communications (2022)

Article

Domain memory effect in the organic ferroics

Shape memory alloys have been used extensively in actuators, couplings, medical guide wires, and smart devices, because of their unique shape memory effect and superelasticity triggered by the reversible marte...

Zhong-**a Wang, **ao-Gang Chen, **an-Jiang Song, Yu-Ling Zeng… in Nature Communications (2022)

Article

Genomic signatures define three subtypes of EGFR-mutant stage II–III non-small-cell lung cancer with distinct adjuvant therapy outcomes

The ADJUVANT study reported the comparative superiority of adjuvant gefitinib over chemotherapy in disease-free survival of resected EGFR-mutant stage II–IIIA non-small cell lung cancer (NSCLC). However, not all ...

Si-Yang Liu, Hua Bao, Qun Wang, Wei-Min Mao, Yedan Chen… in Nature Communications (2021)

Article

The switch of DNA states filtering the extrinsic noise in the system of frequency modulation

There is a special node, which the large noise of the upstream element may not always lead to a broad distribution of downstream elements. This node is DNA, with upstream element TF and downstream elements mRN...

Shih-Chiang Lo, Chao-Xuan You, Bo-Ren Chen, Ching-Chu Hsieh… in Scientific Reports (2021)

Article

Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou, **ng-Lou Yang, **an-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang… in Nature (2020)

Article

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats^1–4. Previous studi...

Peng Zhou, **ng-Lou Yang, **an-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang… in Nature (2020)

Article

Involvement of abscisic acid-responsive element-binding factors in cassava (Manihot esculenta) dehydration stress response

Cassava (Manihot esculenta) is a major staple food, animal feed and energy crop in the tropics and subtropics. It is one of the most drought-tolerant crops, however, the mechanisms of cassava drought tolerance re...

Ren-Jun Feng, Meng-Yun Ren, Li-Fang Lu, Ming Peng, **ao Guan… in Scientific Reports (2019)

Article

The protective effects of maltol on cisplatin-induced nephrotoxicity through the AMPK-mediated PI3K/Akt and p53 signaling pathways

Cisplatin, a potent anticancer drug, is usually causing nephrotoxicity; limiting its therapeutic application and efficiency. Maltol may be used to prevent such toxic effect. The aim of this study was to invest...

**ao-jie Mi, **-gang Hou, Zi Wang, Ye Han, Shen Ren, Jun-nan Hu… in Scientific Reports (2018)

Article

Ginseng oligopeptides protect against irradiation-induced immune dysfunction and intestinal injury

Intestinal injury and immune dysfunction are commonly encountered after irradiation therapy. While the curative abilities of ginseng root have been reported in prior studies, there is little known regarding it...

Li-**a He, Zhao-Feng Zhang, Jian Zhao, Lin Li, Teng Xu, Bin Sun… in Scientific Reports (2018)

Article

In-orbit operation of an atomic clock based on laser-cooled ⁸⁷Rb atoms

Atomic clocks based on laser-cooled atoms are widely used as primary frequency standards. Deploying such cold atom clocks (CACs) in space is foreseen to have many applications. Here we present tests of a CAC o...

Liang Liu, De-Sheng Lü, Wei-Biao Chen, Tang Li, Qiu-Zhi Qu… in Nature Communications (2018)